diff --git a/packages/edit-site/src/components/style-book/index.js b/packages/edit-site/src/components/style-book/index.js
index b9b6b63cfe4a9e..5eca935ad0d257 100644
--- a/packages/edit-site/src/components/style-book/index.js
+++ b/packages/edit-site/src/components/style-book/index.js
@@ -8,6 +8,10 @@ import classnames from 'classnames';
  */
 import {
 	Button,
+	__unstableComposite as Composite,
+	__unstableUseCompositeState as useCompositeState,
+	__unstableCompositeItem as CompositeItem,
+	Disabled,
 	TabPanel,
 	createSlotFill,
 	__experimentalUseSlotFills as useSlotFills,
@@ -20,9 +24,13 @@ import {
 	createBlock,
 } from '@wordpress/blocks';
 import {
-	BlockPreview,
+	BlockList,
 	privateApis as blockEditorPrivateApis,
+	store as blockEditorStore,
+	__unstableEditorStyles as EditorStyles,
+	__unstableIframe as Iframe,
 } from '@wordpress/block-editor';
+import { useSelect } from '@wordpress/data';
 import { closeSmall } from '@wordpress/icons';
 import {
 	useResizeObserver,
@@ -38,12 +46,84 @@ import { ESCAPE } from '@wordpress/keycodes';
  */
 import { unlock } from '../../private-apis';
 
-const { useGlobalStyle } = unlock( blockEditorPrivateApis );
+const { ExperimentalBlockEditorProvider, useGlobalStyle } = unlock(
+	blockEditorPrivateApis
+);
 
 const SLOT_FILL_NAME = 'EditSiteStyleBook';
 const { Slot: StyleBookSlot, Fill: StyleBookFill } =
 	createSlotFill( SLOT_FILL_NAME );
 
+// The content area of the Style Book is rendered within an iframe so that global styles
+// are applied to elements within the entire content area. To support elements that are
+// not part of the block previews, such as headings and layout for the block previews,
+// additional CSS rules need to be passed into the iframe. These are hard-coded below.
+// Note that button styles are unset, and then focus rules from the `Button` component are
+// applied to the `button` element, targeted via `.edit-site-style-book__example`.
+// This is to ensure that browser default styles for buttons are not applied to the previews.
+const STYLE_BOOK_IFRAME_STYLES = `
+	.edit-site-style-book__examples {
+		max-width: 900px;
+		margin: 0 auto;
+	}
+
+	.edit-site-style-book__example {
+		border-radius: 2px;
+		cursor: pointer;
+		display: flex;
+		flex-direction: column;
+		gap: 40px;
+		margin-bottom: 40px;
+		padding: 16px;
+		width: 100%;
+		box-sizing: border-box;
+	}
+
+	.edit-site-style-book__example.is-selected {
+		box-shadow: 0 0 0 1px var(--wp-components-color-accent, var(--wp-admin-theme-color, #007cba));
+	}
+
+	.edit-site-style-book__example:focus:not(:disabled) {
+		box-shadow: 0 0 0 var(--wp-admin-border-width-focus) var(--wp-components-color-accent, var(--wp-admin-theme-color, #007cba));
+		outline: 3px solid transparent;
+	}
+
+	.edit-site-style-book__examples.is-wide .edit-site-style-book__example {
+		flex-direction: row;
+	}
+
+	.edit-site-style-book__example-title {
+		font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Oxygen-Sans, Ubuntu, Cantarell, "Helvetica Neue", sans-serif;
+		font-size: 11px;
+		font-weight: 500;
+		line-height: normal;
+		margin: 0;
+		text-align: left;
+		text-transform: uppercase;
+	}
+
+	.edit-site-style-book__examples.is-wide .edit-site-style-book__example-title {
+		text-align: right;
+		width: 120px;
+	}
+
+	.edit-site-style-book__example-preview {
+		width: 100%;
+	}
+
+	.edit-site-style-book__example-preview .block-editor-block-list__insertion-point,
+	.edit-site-style-book__example-preview .block-list-appender {
+		display: none;
+	}
+
+	.edit-site-style-book__example-preview .is-root-container > .wp-block:first-child {
+		margin-top: 0;
+	}
+	.edit-site-style-book__example-preview .is-root-container > .wp-block:last-child {
+		margin-bottom: 0;
+	}
+`;
+
 function getExamples() {
 	// Use our own example for the Heading block so that we can show multiple
 	// heading levels.
@@ -118,6 +198,15 @@ function StyleBook( { isSelected, onSelect, onClose } ) {
 		[ examples ]
 	);
 
+	const originalSettings = useSelect(
+		( select ) => select( blockEditorStore ).getSettings(),
+		[]
+	);
+	const settings = useMemo(
+		() => ( { ...originalSettings, __unstableIsPreviewMode: true } ),
+		[ originalSettings ]
+	);
+
 	function closeOnEscape( event ) {
 		if ( event.keyCode === ESCAPE && ! event.defaultPrevented ) {
 			event.preventDefault();
@@ -156,12 +245,47 @@ function StyleBook( { isSelected, onSelect, onClose } ) {
 					tabs={ tabs }
 				>
 					{ ( tab ) => (
-						<Examples
-							examples={ examples }
-							category={ tab.name }
-							isSelected={ isSelected }
-							onSelect={ onSelect }
-						/>
+						<Iframe
+							className="edit-site-style-book__iframe"
+							head={
+								<>
+									<EditorStyles styles={ settings.styles } />
+									<style>
+										{
+											// Forming a "block formatting context" to prevent margin collapsing.
+											// @see https://developer.mozilla.org/en-US/docs/Web/Guide/CSS/Block_formatting_context
+											`.is-root-container { display: flow-root; }
+											body { position: relative; padding: 32px !important; }` +
+												STYLE_BOOK_IFRAME_STYLES
+										}
+									</style>
+								</>
+							}
+							name="style-book-canvas"
+							tabIndex={ 0 }
+						>
+							{ /* Filters need to be rendered before children to avoid Safari rendering issues. */ }
+							{ settings.svgFilters }
+							<Examples
+								className={ classnames(
+									'edit-site-style-book__examples',
+									{
+										'is-wide': sizes.width > 600,
+									}
+								) }
+								examples={ examples }
+								category={ tab.name }
+								label={ sprintf(
+									// translators: %s: Category of blocks, e.g. Text.
+									__(
+										'Examples of blocks in the %s category'
+									),
+									tab.title
+								) }
+								isSelected={ isSelected }
+								onSelect={ onSelect }
+							/>
+						</Iframe>
 					) }
 				</TabPanel>
 			</section>
@@ -169,52 +293,83 @@ function StyleBook( { isSelected, onSelect, onClose } ) {
 	);
 }
 
-const Examples = memo( ( { examples, category, isSelected, onSelect } ) => (
-	<div className="edit-site-style-book__examples">
-		{ examples
-			.filter( ( example ) => example.category === category )
-			.map( ( example ) => (
-				<Example
-					key={ example.name }
-					title={ example.title }
-					blocks={ example.blocks }
-					isSelected={ isSelected( example.name ) }
-					onClick={ () => {
-						onSelect( example.name );
-					} }
-				/>
-			) ) }
-	</div>
-) );
-
-const Example = memo( ( { title, blocks, isSelected, onClick } ) => (
-	<button
-		className={ classnames( 'edit-site-style-book__example', {
-			'is-selected': isSelected,
-		} ) }
-		aria-label={ sprintf(
-			// translators: %s: Title of a block, e.g. Heading.
-			__( 'Open %s styles in Styles panel' ),
-			title
-		) }
-		onClick={ onClick }
-	>
-		<span className="edit-site-style-book__example-title">{ title }</span>
-		<div className="edit-site-style-book__example-preview">
-			<BlockPreview
-				blocks={ blocks }
-				viewportWidth={ 0 }
-				additionalStyles={ [
-					{
-						css:
-							'.wp-block:first-child { margin-top: 0; }' +
-							'.wp-block:last-child { margin-bottom: 0; }',
-					},
-				] }
-			/>
-		</div>
-	</button>
-) );
+const Examples = memo(
+	( { className, examples, category, label, isSelected, onSelect } ) => {
+		const composite = useCompositeState( { orientation: 'vertical' } );
+		return (
+			<Composite
+				{ ...composite }
+				className={ className }
+				aria-label={ label }
+			>
+				{ examples
+					.filter( ( example ) => example.category === category )
+					.map( ( example ) => (
+						<Example
+							key={ example.name }
+							id={ `example-${ example.name }` }
+							composite={ composite }
+							title={ example.title }
+							blocks={ example.blocks }
+							isSelected={ isSelected( example.name ) }
+							onClick={ () => {
+								onSelect( example.name );
+							} }
+						/>
+					) ) }
+			</Composite>
+		);
+	}
+);
+
+const Example = ( { composite, id, title, blocks, isSelected, onClick } ) => {
+	const originalSettings = useSelect(
+		( select ) => select( blockEditorStore ).getSettings(),
+		[]
+	);
+	const settings = useMemo(
+		() => ( { ...originalSettings, __unstableIsPreviewMode: true } ),
+		[ originalSettings ]
+	);
+
+	// Cache the list of blocks to avoid additional processing when the component is re-rendered.
+	const renderedBlocks = useMemo(
+		() => ( Array.isArray( blocks ) ? blocks : [ blocks ] ),
+		[ blocks ]
+	);
+
+	return (
+		<CompositeItem
+			{ ...composite }
+			className={ classnames( 'edit-site-style-book__example', {
+				'is-selected': isSelected,
+			} ) }
+			id={ id }
+			aria-label={ sprintf(
+				// translators: %s: Title of a block, e.g. Heading.
+				__( 'Open %s styles in Styles panel' ),
+				title
+			) }
+			onClick={ onClick }
+			role="button"
+			as="div"
+		>
+			<span className="edit-site-style-book__example-title">
+				{ title }
+			</span>
+			<div className="edit-site-style-book__example-preview" aria-hidden>
+				<Disabled className="edit-site-style-book__example-preview__content">
+					<ExperimentalBlockEditorProvider
+						value={ renderedBlocks }
+						settings={ settings }
+					>
+						<BlockList renderAppender={ false } />
+					</ExperimentalBlockEditorProvider>
+				</Disabled>
+			</div>
+		</CompositeItem>
+	);
+};
 
 function useHasStyleBook() {
 	const fills = useSlotFills( SLOT_FILL_NAME );
diff --git a/packages/edit-site/src/components/style-book/style.scss b/packages/edit-site/src/components/style-book/style.scss
index fc88c399cac207..881b117a75ccb3 100644
--- a/packages/edit-site/src/components/style-book/style.scss
+++ b/packages/edit-site/src/components/style-book/style.scss
@@ -26,53 +26,9 @@
 		bottom: 0;
 		left: 0;
 		overflow: auto;
-		padding: $grid-unit-40;
+		padding: 0;
 		position: absolute;
 		right: 0;
 		top: $grid-unit-60; // Height of tabs.
 	}
 }
-
-.edit-site-style-book__examples {
-	max-width: 900px;
-	margin: 0 auto;
-}
-
-.edit-site-style-book__example {
-	background: none;
-	border-radius: $radius-block-ui;
-	border: none;
-	color: inherit;
-	cursor: pointer;
-	display: flex;
-	flex-direction: column;
-	gap: $grid-unit-50;
-	margin-bottom: $grid-unit-50;
-	padding: $grid-unit-20;
-	width: 100%;
-
-	&.is-selected {
-		box-shadow: 0 0 0 1px var(--wp-admin-theme-color);
-	}
-
-	.edit-site-style-book.is-wide & {
-		flex-direction: row;
-	}
-}
-
-.edit-site-style-book__example-title {
-	font-size: 11px;
-	font-weight: 500;
-	margin: 0;
-	text-align: left;
-	text-transform: uppercase;
-
-	.edit-site-style-book.is-wide & {
-		text-align: right;
-		width: 120px;
-	}
-}
-
-.edit-site-style-book__example-preview {
-	width: 100%;
-}
diff --git a/test/e2e/specs/site-editor/style-book.spec.js b/test/e2e/specs/site-editor/style-book.spec.js
index f3c06308b92154..56d0ca0cf20f1b 100644
--- a/test/e2e/specs/site-editor/style-book.spec.js
+++ b/test/e2e/specs/site-editor/style-book.spec.js
@@ -59,37 +59,45 @@ test.describe( 'Style Book', () => {
 		).toBeVisible();
 		await expect( page.locator( 'role=tab[name="Theme"i]' ) ).toBeVisible();
 
+		// Buttons to select block examples are rendered within the Style Book iframe.
+		const styleBookIframe = page.frameLocator(
+			'[name="style-book-canvas"]'
+		);
+
 		await expect(
-			page.locator(
-				'role=button[name="Open Headings styles in Styles panel"i]'
-			)
+			styleBookIframe.getByRole( 'button', {
+				name: 'Open Headings styles in Styles panel',
+			} )
 		).toBeVisible();
 		await expect(
-			page.locator(
-				'role=button[name="Open Paragraph styles in Styles panel"i]'
-			)
+			styleBookIframe.getByRole( 'button', {
+				name: 'Open Paragraph styles in Styles panel',
+			} )
 		).toBeVisible();
 
 		await page.click( 'role=tab[name="Media"i]' );
 
 		await expect(
-			page.locator(
-				'role=button[name="Open Image styles in Styles panel"i]'
-			)
+			styleBookIframe.getByRole( 'button', {
+				name: 'Open Image styles in Styles panel',
+			} )
 		).toBeVisible();
 		await expect(
-			page.locator(
-				'role=button[name="Open Gallery styles in Styles panel"i]'
-			)
+			styleBookIframe.getByRole( 'button', {
+				name: 'Open Gallery styles in Styles panel',
+			} )
 		).toBeVisible();
 	} );
 
 	test( 'should open correct Global Styles panel when example is clicked', async ( {
 		page,
 	} ) => {
-		await page.click(
-			'role=button[name="Open Headings styles in Styles panel"i]'
-		);
+		await page
+			.frameLocator( '[name="style-book-canvas"]' )
+			.getByRole( 'button', {
+				name: 'Open Headings styles in Styles panel',
+			} )
+			.click();
 
 		await expect(
 			page.locator(
@@ -105,9 +113,12 @@ test.describe( 'Style Book', () => {
 		await page.click( 'role=button[name="Heading block styles"]' );
 		await page.click( 'role=button[name="Typography styles"]' );
 
-		await page.click(
-			'role=button[name="Open Quote styles in Styles panel"i]'
-		);
+		await page
+			.frameLocator( '[name="style-book-canvas"]' )
+			.getByRole( 'button', {
+				name: 'Open Quote styles in Styles panel',
+			} )
+			.click();
 
 		await page.click( 'role=button[name="Navigate to the previous view"]' );
 		await page.click( 'role=button[name="Navigate to the previous view"]' );