diff --git a/src/Wpf/Prism.Wpf/Regions/RegionManager.cs b/src/Wpf/Prism.Wpf/Regions/RegionManager.cs
index ed6f461e76..32f128d5dd 100644
--- a/src/Wpf/Prism.Wpf/Regions/RegionManager.cs
+++ b/src/Wpf/Prism.Wpf/Regions/RegionManager.cs
@@ -241,7 +241,7 @@ public static void UpdateRegions()
         private static bool IsInDesignMode(DependencyObject element)
         {
 #if HAS_UWP || HAS_WINUI
-            return false;
+            return Windows.ApplicationModel.DesignMode.DesignModeEnabled;
 #else
             return DesignerProperties.GetIsInDesignMode(element);
 #endif