diff --git a/Cimetidine-Carbamazepine-DDI.json b/Cimetidine-Carbamazepine-DDI.json index db9eaf6..cf594a2 100644 --- a/Cimetidine-Carbamazepine-DDI.json +++ b/Cimetidine-Carbamazepine-DDI.json @@ -2296,6 +2296,9 @@ { "Name": "Dalton1985a_TreatmentPhase", "Model": "4Comp", + "ObservedData": [ + "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)" + ], "Solver": {}, "OutputSchema": [ { @@ -2785,6 +2788,13 @@ "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)" ], + "OutputMappings": [ + { + "Scaling": "Log", + "Path": "Dalton1985a_TreatmentPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", + "ObservedData": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)" + } + ], "Individual": "Dalton1985a", "Compounds": [ { @@ -2926,6 +2936,17 @@ "Color": "#FF0000", "LegendIndex": 2 } + }, + { + "Name": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", + "X": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|Time", + "Y": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", + "CurveOptions": { + "Color": "#0000FF", + "LegendIndex": 3, + "LineStyle": "None", + "Symbol": "Circle" + } } ], "Name": "Dalton1985_control_600mg_sd_tabIR", @@ -3137,7 +3158,7 @@ } }, { - "Name": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)", + "Name": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)", "ExtendedProperties": [ { "Name": "DB Version", @@ -3146,7 +3167,7 @@ }, { "Name": "ID", - "Value": 899.0, + "Value": 900.0, "Type": "Double" }, { @@ -3166,7 +3187,7 @@ }, { "Name": "Grouping", - "Value": "Placebo (without cimetidine)", + "Value": "Treatment with cimetidine", "Type": "String" }, { @@ -3181,7 +3202,7 @@ }, { "Name": "Molecule", - "Value": "Carbamazepine-10-11-epoxide", + "Value": "Carbamazepine", "Type": "String" }, { @@ -3211,7 +3232,7 @@ }, { "Name": "Times of Administration [h]", - "Value": 0.0, + "Value": 47.0, "Type": "Double" }, { @@ -3234,32 +3255,34 @@ { "Name": "Avg", "QuantityInfo": { - "Path": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|Individual" + "Path": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual" }, "DataInfo": { "Origin": "Observation", "AuxiliaryType": "Undefined", - "MolWeight": 252.27 + "MolWeight": 236.269 }, "Values": [ - 0.053707, - 0.07731663, - 0.1036509, - 0.123794608, - 0.1316764, - 0.1964428, - 0.184402, - 0.2722675, - 0.2119635, - 0.211669, - 0.1439989, - 0.1701291, - 0.1086979, - 0.08014562, - 0.0622773245, - 0.05787384, - 0.0383134, - 0.02799919 + 2.717103, + 3.642302, + 3.944307, + 4.309525, + 4.424255, + 4.154807, + 4.744039, + 4.034985, + 3.589273, + 4.282947, + 2.64168, + 2.805384, + 1.639702, + 1.309783, + 0.9735537, + 0.8203106, + 0.6097317, + 0.5137563, + 0.4643707, + 0.3275169 ], "Dimension": "Concentration (mass)", "Unit": "mg/l" @@ -3268,7 +3291,7 @@ "BaseGrid": { "Name": "Time", "QuantityInfo": { - "Path": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)|Time", + "Path": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|Time", "Type": "Time" }, "DataInfo": { @@ -3276,37 +3299,30 @@ "AuxiliaryType": "Undefined" }, "Values": [ - 2.0, - 4.0, - 6.0, - 8.0, - 10.0, - 12.0, - 16.0, - 24.0, - 30.0, - 36.0, - 48.0, - 58.0, - 72.0, - 82.0, - 96.0, - 106.0, - 120.0, - 130.0 + 49.0, + 51.0, + 53.0, + 55.0, + 57.0, + 59.0, + 63.0, + 71.0, + 77.0, + 83.0, + 95.0, + 105.0, + 119.0, + 129.0, + 143.0, + 153.0, + 167.0, + 177.0, + 191.0, + 201.0 ], "Dimension": "Time", "Unit": "h" } } - ], - "ObservedDataClassifications": [ - { - "Name": "Dalton 1985a", - "Classifiables": [ - "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)", - "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)" - ] - } ] } \ No newline at end of file