diff --git a/ui/components/multichain/network-list-menu/network-list-menu.js b/ui/components/multichain/network-list-menu/network-list-menu.js
index 33832a0a9f88..41beac5744bc 100644
--- a/ui/components/multichain/network-list-menu/network-list-menu.js
+++ b/ui/components/multichain/network-list-menu/network-list-menu.js
@@ -28,6 +28,7 @@ import {
   getShowNetworkBanner,
   getOriginOfCurrentTab,
   getUseRequestQueue,
+  getAllDomains,
 } from '../../../selectors';
 import ToggleButton from '../../ui/toggle-button';
 import {
@@ -76,6 +77,7 @@ export const NetworkListMenu = ({ onClose }) => {
 
   const selectedTabOrigin = useSelector(getOriginOfCurrentTab);
   const useRequestQueue = useSelector(getUseRequestQueue);
+  const domains = useSelector(getAllDomains);
 
   const dispatch = useDispatch();
   const history = useHistory();
@@ -193,10 +195,14 @@ export const NetworkListMenu = ({ onClose }) => {
             dispatch(setActiveNetwork(network.id));
           }
 
-          // If presently on a dapp, communicate a change to
-          // the dapp via silent switchEthereumChain that the
-          // network has changed due to user action
-          if (useRequestQueue && selectedTabOrigin) {
+          // If presently on and connected to a dapp, communicate a change to
+          // the dapp via silent switchEthereumChain that the network has
+          // changed due to user action
+          if (
+            useRequestQueue &&
+            selectedTabOrigin &&
+            domains[selectedTabOrigin]
+          ) {
             setNetworkClientIdForDomain(selectedTabOrigin, network.id);
           }
 
diff --git a/ui/components/multichain/network-list-menu/network-list-menu.test.js b/ui/components/multichain/network-list-menu/network-list-menu.test.js
index 83ebf8d03250..fa313c373752 100644
--- a/ui/components/multichain/network-list-menu/network-list-menu.test.js
+++ b/ui/components/multichain/network-list-menu/network-list-menu.test.js
@@ -7,25 +7,32 @@ import {
   CHAIN_IDS,
   MAINNET_DISPLAY_NAME,
   SEPOLIA_DISPLAY_NAME,
+  NETWORK_TYPES,
 } from '../../../../shared/constants/network';
 import { NetworkListMenu } from '.';
 
 const mockSetShowTestNetworks = jest.fn();
 const mockSetProviderType = jest.fn();
 const mockToggleNetworkMenu = jest.fn();
+const mockSetNetworkClientIdForDomain = jest.fn();
 
 jest.mock('../../../store/actions.ts', () => ({
   setShowTestNetworks: () => mockSetShowTestNetworks,
   setProviderType: () => mockSetProviderType,
   toggleNetworkMenu: () => mockToggleNetworkMenu,
+  setNetworkClientIdForDomain: (network, id) =>
+    mockSetNetworkClientIdForDomain(network, id),
 }));
 
+const MOCK_ORIGIN = 'https://portfolio.metamask.io';
+
 const render = ({
   showTestNetworks = false,
   currentChainId = '0x5',
   providerConfigId = 'chain5',
   isUnlocked = true,
-  origin = 'https://portfolio.metamask.io',
+  origin = MOCK_ORIGIN,
+  selectedTabOriginInDomainsState = true,
 } = {}) => {
   const state = {
     metamask: {
@@ -40,6 +47,11 @@ const render = ({
         showTestNetworks,
       },
       useRequestQueue: true,
+      domains: {
+        ...(selectedTabOriginInDomainsState
+          ? { [origin]: providerConfigId }
+          : {}),
+      },
     },
     activeTab: {
       origin,
@@ -51,6 +63,10 @@ const render = ({
 };
 
 describe('NetworkListMenu', () => {
+  beforeEach(() => {
+    jest.clearAllMocks();
+  });
+
   it('displays important controls', () => {
     const { getByText, getByPlaceholderText } = render();
 
@@ -140,4 +156,32 @@ describe('NetworkListMenu', () => {
       document.querySelectorAll('multichain-network-list-item__delete'),
     ).toHaveLength(0);
   });
+
+  describe('selectedTabOrigin is connected to wallet', () => {
+    it('fires setNetworkClientIdForDomain when network item is clicked', () => {
+      const { getByText } = render();
+      fireEvent.click(getByText(MAINNET_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
+        MOCK_ORIGIN,
+        NETWORK_TYPES.MAINNET,
+      );
+    });
+
+    it('fires setNetworkClientIdForDomain when test network item is clicked', () => {
+      const { getByText } = render({ showTestNetworks: true });
+      fireEvent.click(getByText(SEPOLIA_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
+        MOCK_ORIGIN,
+        NETWORK_TYPES.SEPOLIA,
+      );
+    });
+  });
+
+  describe('selectedTabOrigin is not connected to wallet', () => {
+    it('does not fire setNetworkClientIdForDomain when network item is clicked', () => {
+      const { getByText } = render({ selectedTabOriginInDomainsState: false });
+      fireEvent.click(getByText(MAINNET_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).not.toHaveBeenCalled();
+    });
+  });
 });