diff --git a/.gitignore b/.gitignore new file mode 100644 index 0000000..d6fc90d --- /dev/null +++ b/.gitignore @@ -0,0 +1,28 @@ +/.quarto/ +.DS_Store + +# History files +.Rhistory +.Rapp.history + +# Session Data files +.RData +.Ruserdata + +# RStudio files +.Rproj.user/ + +# knitr and R markdown default cache directories +*_cache +cache/ + +# Temporary files created by R markdown +*.utf8.md +*.knit.md + +TODO +OLD +checks/ +data/ +extra/ +deskstatshfdb4/ \ No newline at end of file diff --git a/.nojekyll b/.nojekyll new file mode 100644 index 0000000..e69de29 diff --git a/404.qmd b/404.qmd new file mode 100644 index 0000000..7c14d8a --- /dev/null +++ b/404.qmd @@ -0,0 +1,5 @@ +--- +title: "404" +--- + +Page not found, sorry! Try the search or navigate back to the base website. \ No newline at end of file diff --git a/README.md b/README.md new file mode 100644 index 0000000..e6871a6 --- /dev/null +++ b/README.md @@ -0,0 +1,9 @@ +# Code for creating website with info on construction of SHFDB4 + +## Language + +English. + +## Website + +https://kiheartfailure.github.io/shfdb4 diff --git a/_freeze/definitions/index/execute-results/html.json b/_freeze/definitions/index/execute-results/html.json new file mode 100644 index 0000000..f938b37 --- /dev/null +++ b/_freeze/definitions/index/execute-results/html.json @@ -0,0 +1,14 @@ +{ + "hash": "8bb0e32b8c25620e3b4b633ba0880167", + "result": { + "markdown": "---\ntitle: Definitions\n---\n\n\n\n::: {.cell}\n\n:::\n\n\n## Index date\n\n\nIndex date is defined as the registered date of discharge for in-patients and date of admission for out-patients in SwedeHF. For the patients identified through the National Patient Register with ICD codes the index date is defined as the first occurrence of a diagnosis of HF in main position. The controls receive the same index date as their matched case.\n\n----\n\n## Follow-up\n\nThe follow-up period is defined as time from index date to emigration, death or end of follow-up, 2021-12-31, whichever came first.\n\nFor the controls the follow-up period is defined as time from the matched cases index date to heart failure diagnosis (either in NPR or SwedeHF), emigration, death or end of follow-up, 2021-12-31, whichever came first.\n\n----\n\n## Socio-economic variables\n\nThe socio-economic variables from LISA, Statistics Sweden, are from the year prior to the index year, so a patient with an index date 2015-03-06 will have income, marriage status and education from 2014.\n\nLimitations: Unmarried persons cohabiting without children are classified as Living alone. Education is not registered for individuals < 25 years.\n\n----\n\n## Comorbidities and outcomes\n\nFor all comorbidities and hospitalizations from the NPR date of admission/visit (INDATUM) is used to calculate if it is a comorbidity or outcome. Adjoining hospitalizations, where the discharge date of the former hospitalization is the same as the admission date of the latter, are merged together into one hospitalization in order to take into account possible transferrals between wards/hospitals.\n\nLimitation: For the comorbidities MI, IHD, Stroke, CABG and PCI there is no time restriction applied. There is no data prior to 1987 (for PCI, CABG only from 1997) and the earlier registrations will therefore not have had the possibility to accumulate comorbidities to the same extent as the latter. For more details see [Data Sources](https://kiheartfailure.github.io/shfdb4/datasources/))).\n\nLimitation: Out-patient visits in speciality (but not primary) care are covered from 2001. Therefore, for the earlier visits, these are (partially) not included in the comorbidities.\n\n\n::: {.cell}\n::: {.cell-output-display}\n`````{=html}\n\n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
Variable Code Register Position Period
sos_com_hypertension ICD:I10-5 NPR (in+out) All DIA -5yrs-0
sos_com_diabetes ICD:E10-4 NPR (in+out) All DIA -5yrs-0
sos_com_ihd ICD:410-4, I20-5 NPR (in+out) All DIA -0
sos_com_mi ICD:410, 412, I21, I22, I252 NPR (in+out) All DIA -0
sos_com_angina ICD:I20 NPR (in+out) All DIA -5yrs-0
sos_com_pci OP:FNG NPR (in+out) All OP -0
sos_com_cabg ICD:Z951, Z955 OP:FNA, FNB, FNC, FND, FNE, FNF, FNH NPR (in+out) All DIA All OP -0
sos_com_dcm ICD:I420 NPR (in+out) All DIA -5yrs-0
sos_com_pad ICD:I70-3 NPR (in+out) All DIA -5yrs-0
sos_com_af ICD:I48 NPR (in+out) All DIA -5yrs-0
sos_com_stroke ICD:430-4, 438, I60-4, I690-4 NPR (in+out) All DIA -0
sos_com_tia ICD:G45 NPR (in+out) All DIA -5yrs-0
sos_com_valvular ICD:I05-8, I34-9, Q22, Q230-3, Q230-3, Q235-9, Z952-4 NPR (in+out) All DIA -5yrs-0
sos_com_renal ICD:N17-9, Z491, Z492 OP:KAS00, KAS10, KAS20, DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35 NPR (in+out) All DIA All OP -5yrs-0
sos_com_hyperkalemia ICD:E875 NPR (in+out) All DIA -5yrs-0
sos_com_hypokalemia ICD:E876 NPR (in+out) All DIA -5yrs-0
sos_com_dialysis ICD:Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35 NPR (in+out) All DIA All OP -5yrs-0
sos_com_copd ICD:J40-4 NPR (in+out) All DIA -5yrs-0
sos_com_respiratory ICD:J NPR (in+out) All DIA -5yrs-0
sos_com_liver ICD:B18, I85, I864, I982, K70, K710, K711, K713-7, K72-4, K760, K762-9 NPR (in+out) All DIA -5yrs-0
sos_com_sleepapnea ICD:G473 NPR (in+out) All DIA -5yrs-0
sos_com_dementia ICD:F00-4, R54 NPR (in+out) All DIA -5yrs-0
sos_com_depression ICD:F32-4 NPR (in+out) All DIA -5yrs-0
sos_com_cancer3y ICD:C NPR (in+out) HDIA -3yrs-0
sos_com_muscoloskeletal3y ICD:M NPR (in+out) All DIA -3yrs-0
sos_com_alcohol ICD:E244, E52, F10, G312, G621, G721, I426, K292, K70, K860, O354, P043, Q860, T51, Z502, Z714 Ekod:Y90, Y91 NPR (in+out) All DIA All Ekod -5yrs-0
sos_com_bleed ICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029 NPR (in+out) All DIA All OP -5yrs-0
sos_out_hosphf ICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428 NPR (in) HDIA 1-
sos_out_counthosphf ICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428 NPR (in) HDIA 1-
sos_out_hospany ICD: NPR (in) HDIA 1-
sos_out_hospcv ICD:I, J81, K761, G45, R570 NPR (in) HDIA 1-
sos_out_hospnoncv ICD:Not I, J81, K761, G45, R570 NPR (in) HDIA 1-
sos_out_hospstroketia ICD:I60-4, G45 NPR (in) HDIA 1-
sos_out_hospmi ICD:I21, I22 NPR (in) HDIA 1-
sos_out_hospihd ICD:I20-5 NPR (in) HDIA 1-
sos_out_hospventfib ICD:I490, I472 NPR (in) HDIA 1-
sos_out_hospscd ICD:I461 NPR (in) HDIA 1-
sos_out_hosprespiratory ICD:J NPR (in) HDIA 1-
sos_out_hosppneumonia ICD:J09, J10-8 NPR (in) HDIA 1-
sos_out_hosprenal ICD:N17-9, KAS00, KAS10, KAS20, Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35 NPR (in) HDIA All OP 1-
sos_out_hospcancer ICD:C NPR (in) HDIA 1-
sos_out_hospbleed ICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029 NPR (in) HDIA All OP 1-
sos_out_hosphyperkalemia ICD:E875 NPR (in) HDIA 1-
sos_out_hosphypokalemia ICD:E876 NPR (in) HDIA 1-
sos_out_hospsyncope ICD:R55 NPR (in) HDIA 1-
sos_out_hosptrauma ICD:S, T0, T10-4 NPR (in) HDIA 1-
sos_out_hosprevasc OP:FNG, FNA, FNB, FNC, FND, FNE, FNF, FNH NPR (in) All OP 1-
sos_out_deathcv ICD:I, J81, K761, R570, G45 Cause of Death ULORSAK
sos_out_deathscd ICD:I461 Cause of Death ULORSAK
\n\n`````\n:::\n:::\n\n\n----\n\n## Charlson comorbidity index\n\nThe ICD-9/10 codes used are not necessarily the same as in the other comorbidities and outcomes but \nfrom https://www.dovepress.com/articles.php?article_id=61144. \n\n\n::: {.cell}\n::: {.cell-output-display}\n`````{=html}\n\n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
Variable Code Register Position Period
sos_com_cci_mi ICD:410, 412, I21, I22, I252 NPR (in+out) All DIA -10yrs-0
sos_com_cci_chf ICD:402A, 402B, 402X, 404A, 404B, 404X, 425E, 425F, 425H, 425W, 425X, 428, I110, I130, I132, I255, I420, I426-9, I43, I50 NPR (in+out) All DIA -10yrs-0
sos_com_cci_pvd ICD:440, 441, 443B, 443X, 447B, 557, I70, I71, I731, I738, I739, I771, I790, I792, K55 NPR (in+out) All DIA -10yrs-0
sos_com_cci_cd ICD:430-8, G45, I60-4, I67, I69 NPR (in+out) All DIA -10yrs-0
sos_com_cci_copd ICD:491, 492, 496, J43-4 NPR (in+out) All DIA -10yrs-0
sos_com_cci_copdother ICD:490, 493-5, 500-8, 516, 517, J41, J42, J45-7, J60-9, J70 NPR (in+out) All DIA -10yrs-0
sos_com_cci_rheumatic ICD:446, 696A, 710A-E, 714, 719D, 720, 725, M05, M06, M123, M070-3, M08, M13, M30, M313-6, M32, M33, M34, M350, M351, M353, M45, M46 NPR (in+out) All DIA -10yrs-0
sos_com_cci_dementia ICD:290, 294B, 331A-C, 331X, F00-3, F051, G30, G311, G319 NPR (in+out) All DIA -10yrs-0
sos_com_cci_plegia ICD:342, 343, 344A-F, G114, G80-2, G830-3, G838 NPR (in+out) All DIA -10yrs-0
sos_com_cci_diabetes ICD:250A-C, E100, E101, E110, E111, E120, E121, E130, E131, E140, E141 NPR (in+out) All DIA -10yrs-0
sos_com_cci_diabetescompliation ICD:250D-G, E102-5, E107, E112-7, E122-7, E132-7, E142-7 NPR (in+out) All DIA -10yrs-0
sos_com_cci_renal ICD:403A, 403B, 403X, 582, 583, 585, 586, 588A, V42A, V45B, V56, N032-7, N052-7, N11, N18, N19, N250, I120, I131, Q611-4, Z49, Z940, Z992 NPR (in+out) All DIA -10yrs-0
sos_com_cci_livermild ICD:070, 571C, 571E, 571F, 573, B15-9, K703, K73, K746, K703, K754 NPR (in+out) All DIA -10yrs-0
sos_com_cci_liverspec ICD:789F, R18 NPR (in+out) All DIA -10yrs-0
sos_com_cci_livermodsev ICD:789F, 456A-C, 572D-E, 572C, R18, I850, I859, I982, I983 NPR (in+out) All DIA -10yrs-0
sos_com_cci_pud ICD:531-4, K25-8 NPR (in+out) All DIA -10yrs-0
sos_com_cci_malignancy ICD:14-9, 200-8, C0-7, C80-6, C88-9, C90-7 NPR (in+out) All DIA -10yrs-0
sos_com_cci_metastatictumor ICD:196-8, 199A, 199B, C77-9, C80 NPR (in+out) All DIA -10yrs-0
sos_com_cci_hiv ICD:079J, 279K, B20-4, F024, O987, R75, Z114, Z219, Z711 NPR (in+out) All DIA -10yrs-0
\n\n`````\n:::\n:::\n", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": {}, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_freeze/docs/variabledescription/index/execute-results/html.json b/_freeze/docs/variabledescription/index/execute-results/html.json new file mode 100644 index 0000000..4442051 --- /dev/null +++ b/_freeze/docs/variabledescription/index/execute-results/html.json @@ -0,0 +1,14 @@ +{ + "hash": "0522c89ef04fa595b48c7cacbf40424a", + "result": { + "markdown": "---\nlayout: page\ntitle: Variable description\nexecute:\n freeze: true # never re-render during project render\nengine: knitr \nresources:\n - \"meta_variables.xlsx\"\nvardesc:\n xlsx: \"meta_variables.xlsx\"\n---\n\n::: {.cell}\n\n:::\n\n```{=html}\n

\n \n  Download current CV\n \n

\n
\n \n
\n```\n\n```{=html}\n
\nView the tutorial for this template (+ download link)\n
\n```\n", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": {}, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_freeze/overview/index/execute-results/html.json b/_freeze/overview/index/execute-results/html.json new file mode 100644 index 0000000..4a79cb0 --- /dev/null +++ b/_freeze/overview/index/execute-results/html.json @@ -0,0 +1,18 @@ +{ + "hash": "765bd08d63a871b1c7f6374aaa814518", + "result": { + "markdown": "---\ntitle: Overview\nresources:\n - \"meta_variables.xlsx\"\n---\n\n\n## Over time - interactive\n\nDescriptive statistics over time can be found: [https://swedehf.shinyapps.io/deskstatshfdb4](https://swedehf.shinyapps.io/deskstatshfdb4)\n\n----\n\n## Descriptive statistics\n\n\n\n\n::: {.cell}\n\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n`````{=html}\n\n \n\n\n\n\n\n\n\n\n \n \n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n\n\n\n\n\n\n
Patients (last post)
Posts
Variable % missing SwedeHF % missing SwedeHF Case NPR Control SwedeHF Control NPR
n 114375 206634 422876 388838 782222
ncontrols 0.0 2.0 [2.0, 2.0] 0.0 2.0 [2.0, 2.0] 2.0 [2.0, 2.0] 0.0 [0.0, 0.0] 0.0 [0.0, 0.0]
Time in hospital at index hospitalization (days)1 60.9 5.0 [3.0, 9.0] 63.8 5.0 [3.0, 9.0]
Index year1 0.0 2015.0 [2010.0, 2019.0] 0.0 2014.0 [2010.0, 2018.0] 2011.0 [2005.0, 2016.0] 2014.0 [2010.0, 2018.0] 2010.0 [2005.0, 2016.0]
Type of visit Index1 0.0 68651 (60.0) 0.0 115634 (56.0)
LVEF (%)1 85.6 40.0 [30.0, 50.0] 86.5 39.0 [30.0, 45.0]
LVEF (%)1 19.9 17.1
    ≥50 23497 (25.7) 38003 (22.2)
    40-49 22033 (24.1) 39894 (23.3)
    30-39 23867 (26.1) 46520 (27.2)
    <30 22177 (24.2) 46790 (27.3)
LVEF (%)1 19.9 17.1
    HFrEF 46044 (50.3) 93310 (54.5)
    HFmrEF 22033 (24.1) 39894 (23.3)
    HFpEF 23497 (25.7) 38003 (22.2)
Sex Male1 0.0 70503 (61.6) 0.0 132380 (64.1) 226402 (53.5) 244109 (62.8) 408993 (52.3)
Age (years)1 0.0 77.0 [69.0, 84.0] 0.0 76.0 [67.0, 83.0] 80.0 [71.0, 86.0] 75.0 [67.0, 82.0] 79.0 [70.0, 85.0]
Civil status Single1 27.9 36905 (44.8) 27.5 63189 (42.2)
Living conditions Own home1 44.5 59898 (94.4) 44.4 110190 (95.8)
Location In-patient1 0.0 44750 (39.1) 0.0 74851 (36.2)
Smoking1 26.9 23.3
    Current 9116 (10.9) 17267 (10.9)
    Former 36685 (43.9) 70920 (44.8)
    Never 37769 (45.2) 70225 (44.3)
Smoking1 26.9 9116 (10.9) 23.3 17267 (10.9)
Alcohol Risk1 42.5 2836 (4.3) 38.9 5179 (4.1)
Duration of HF ≥6mo1 2.8 68600 (61.7) 2.5 124933 (62.0)
Primary etiology1 40.9 40.3
    DCM 4597 (6.8) 10169 (8.2)
    Heart valve disease 5387 (8.0) 9187 (7.4)
    Hypertension 17917 (26.5) 31520 (25.5)
    IHD 26407 (39.1) 50168 (40.6)
    Known alcoholic cardiomyopathy 467 (0.7) 898 (0.7)
    Other 12828 (19.0) 21510 (17.4)
NYHA class1 30.0 26.1
    I 10233 (12.8) 17921 (11.7)
    II 37273 (46.5) 73193 (48.0)
    III 29222 (36.5) 56325 (36.9)
    IV 3390 (4.2) 5173 (3.4)
NYHA class III-IV1 30.0 32612 (40.7) 26.1 61498 (40.3)
Killip class1 94.4 95.8
    Chock or hypertension 17 (0.3) 27 (0.3)
    Edema 160 (2.5) 217 (2.5)
    No signs of HF 2904 (45.4) 4128 (47.3)
    Rales or crackles 3310 (51.8) 4349 (49.9)
Weight (kg)1 12.9 77.4 [66.0, 90.0] 11.8 79.0 [67.8, 91.5]
Weight at admission/visit (kg)1 32.7 78.0 [66.4, 90.4] 37.2 79.0 [68.0, 91.8]
Weight at discharge   (hospitalized patients) (kg)1 94.8 75.5 [63.5, 88.7] 96.1 77.0 [65.0, 90.0]
Height (cm)1 32.0 172.0 [164.0, 179.0] 26.0 172.0 [165.0, 179.0]
Systolic blood pressure (mmHg)1 3.9 125.0 [110.0, 140.0] 3.3 125.0 [110.0, 140.0]
Systolic blood pressure at admission/visit (mmHg)1 25.0 126.0 [112.0, 140.0] 30.4 125.0 [112.0, 140.0]
Systolic blood pressure at discharge   (hospitalized patients) (mmHg)1 94.0 125.0 [111.0, 140.0] 95.5 125.0 [110.0, 140.0]
Diastolic blood pressure (mmHg)1 3.8 70.0 [65.0, 80.0] 3.2 70.0 [65.0, 80.0]
Diastolic blood pressure at admission/visit (mmHg)1 25.0 72.0 [65.0, 80.0] 30.3 72.0 [65.0, 80.0]
Diastolic blood pressure at discharge   (hospitalized patients) (mmHg)1 93.9 72.0 [65.0, 80.0] 95.5 72.0 [65.0, 80.0]
Mean arterial pressure1 3.8 90.0 [81.7, 99.7] 3.2 90.0 [81.7, 99.0]
Mean arterial pressure >901 3.8 52421 (47.6) 3.2 94489 (47.2)
Heart rate (beats/min)1 6.5 71.0 [63.0, 82.0] 5.7 71.0 [63.0, 81.0]
Heart rate at admission/visit (beats/min)1 27.0 72.0 [63.0, 83.0] 32.1 71.0 [63.0, 82.0]
Heart rate at discharge   (hospitalized patients) (beats/min)1 94.2 74.0 [65.0, 85.0] 95.6 74.0 [65.0, 85.0]
Heart rate (beats/min) >701 6.5 55096 (51.5) 5.7 98701 (50.7)
Hemoglobin (g/L)1 8.2 131.0 [118.0, 143.0] 8.1 132.0 [120.0, 144.0]
Hemoglobin at admission/visit (g/L)1 29.2 132.0 [119.0, 144.0] 34.7 133.0 [120.0, 145.0]
Hemoglobin at discharge   (hospitalized patients) (g/L)1 96.3 119.0 [106.0, 135.0] 97.2 122.0 [107.0, 137.0]
Anemia1 8.2 39397 (37.5) 8.1 66947 (35.2)
Potassium (mmol/L)1 19.9 4.2 [3.9, 4.5] 18.7 4.2 [3.9, 4.5]
Potassium at admission/visit (mmol/L)1 36.0 4.2 [3.9, 4.5] 39.9 4.2 [3.9, 4.5]
Potassium at discharge   (hospitalized patients) (mmol/L)1 94.8 4.0 [3.7, 4.3] 96.1 4.0 [3.7, 4.3]
Potassium (mmol/L)1 19.9 18.7
    Normakalemia 83777 (91.5) 155018 (92.3)
    Hypokalemia 4060 (4.4) 6444 (3.8)
    Hyperkalemia 3725 (4.1) 6446 (3.8)
Sodium (mmol/l)1 35.0 140.0 [138.0, 142.0] 35.1 140.0 [138.0, 142.0]
Sodium at admission/visit (mmol/l)1 46.8 140.0 [138.0, 142.0] 50.5 140.0 [138.0, 142.0]
Sodium at discharge   (hospitalized patients) (mmol/l)1 95.0 140.0 [138.0, 142.0] 96.2 140.0 [138.0, 142.0]
Creatinine (µmol/L)1 3.2 97.0 [79.0, 126.0] 2.9 97.0 [79.0, 124.0]
Creatinine at admission/visit (µmol/L)1 24.6 95.0 [78.0, 122.0] 30.2 94.0 [77.0, 119.0]
Creatinine at discharge   (hospitalized patients) (µmol/L)1 94.8 100.0 [78.0, 133.0] 96.1 97.0 [78.0, 128.0]
eGFR (mL/min/1.73 m²)1 2.9 62.7 [44.8, 82.7] 2.7 64.0 [46.4, 83.4]
eGFR (mL/min/1.73 m²) <601 2.9 51262 (46.2) 2.7 88931 (44.2)
NT-proBNP (pg/ml)1 44.7 2066.0 [812.0, 4950.0] 44.1 2000.0 [810.0, 4563.0]
NT-proBNP at admission/visit (pg/ml)1 55.0 1971.0 [770.0, 4633.0] 57.6 1900.0 [765.0, 4296.0]
NT-proBNP at discharge   (hospitalized patients) (pg/ml)1 97.9 3660.0 [1657.0, 8656.5] 98.4 3380.0 [1574.0, 7652.5]
BNP (pg/ml)1 95.6 580.0 [219.0, 1335.5] 95.1 527.0 [202.0, 1230.0]
Transferrin (%)1 89.7 24.0 [17.0, 32.0] 90.5 24.0 [17.0, 33.0]
Ferritin (µg/l)1 87.9 142.0 [71.0, 264.0] 88.8 142.0 [71.0, 262.0]
QRS width (ms)1 22.3 104.0 [90.0, 132.0] 22.2 106.0 [92.0, 136.0]
Left Bundle Branch Block (LBBB)1 21.7 15800 (17.6) 21.7 30529 (18.9)
Loop diuretic IV1 81.3 5479 (25.5) 82.3 7554 (20.6)
Ferric carboxymaltose IV1 57.2 2501 (5.1) 59.6 3917 (4.7)
Ferric carboxymaltose IV dose (mg)1 97.9 1000.0 [1000.0, 1000.0] 98.2 1000.0 [1000.0, 1000.0]
Unplanned inotrope support1 39.4 1356 (2.0) 40.0 3640 (2.9)
Diuretic1 0.6 86951 (76.5) 0.5 158572 (77.1)
Loop diuretic1 27.4 60440 (72.8) 27.8 108999 (73.1)
Loop diuretic substance1 72.9 75.5
    Bumetanid 230 (0.7) 339 (0.7)
    Furosemid 30618 (98.8) 50174 (98.9)
    Toresamid 127 (0.4) 203 (0.4)
Loop diuretic dose (mg/24h)1 54.9 40.0 [40.0, 80.0] 54.6 40.0 [40.0, 80.0]
Loop diuretic usage When necessary1 47.3 11615 (19.3) 47.4 20892 (19.2)
ACEi1 0.6 54926 (48.3) 0.4 104596 (50.8)
ACEi dose (mg/24h)1 52.1 10.0 [5.0, 15.0] 49.5 10.0 [5.0, 15.0]
ARB1 1.1 30970 (27.4) 0.9 59400 (29.0)
ARB dose (mg/24h)1 73.0 32.0 [15.0, 50.0] 71.3 32.0 [12.5, 50.0]
ARNi1 56.0 6960 (13.8) 58.6 11611 (13.6)
ACEi/ARB/ARNi1 1.3 91155 (80.7) 1.1 172045 (84.1)
Beta-blocker1 0.5 98019 (86.1) 0.4 180675 (87.8)
Beta-blocker dose (mg/24h)1 14.5 25.0 [7.5, 100.0] 12.8 25.0 [7.5, 100.0]
MRA1 0.9 42376 (37.4) 0.6 79343 (38.6)
MRA dose (mg/24h)1 75.3 25.0 [25.0, 25.0] 75.5 25.0 [25.0, 25.0]
Digoxin1 0.6 14862 (13.1) 0.4 27435 (13.3)
Platelet inhibitor1 0.6 44577 (39.2) 0.5 80458 (39.1)
Oral anticoagulant1 0.6 52927 (46.6) 0.5 99517 (48.4)
Statin1 0.5 52912 (46.5) 0.4 101529 (49.3)
Nitrate1 0.7 15034 (13.2) 0.5 26719 (13.0)
SGLT2i1 91.7 2022 (21.3) 94.9 2186 (20.9)
SGLT2i dose (mg/24h)1 98.2 10.0 [10.0, 10.0] 98.9 10.0 [10.0, 10.0]
Sinus node inhibitor1 58.3 248 (0.5) 61.3 473 (0.6)
Device therapy1 1.4 1.7
    No 93068 (82.5) 164078 (80.8)
    Pacemaker 10685 (9.5) 19200 (9.5)
    CRT-P 2154 (1.9) 4370 (2.2)
    CRT-D 3369 (3.0) 7741 (3.8)
    ICD 3524 (3.1) 7669 (3.8)
Device therapy CRT/ICD1 1.4 9047 (8.0) 1.7 19780 (9.7)
Chest X-ray1 37.0 35.2
    No 18770 (26.0) 36050 (26.9)
    Normal 17955 (24.9) 32987 (24.6)
    Pulmonary congestion 9713 (13.5) 16557 (12.4)
    Cardiomegaly 11934 (16.6) 23395 (17.5)
    Pulmonary congestion & cardiomegaly 13718 (19.0) 24955 (18.6)
Diabetes1 10.3 17712 (17.3) 9.7 34450 (18.5)
Diabetes1 28.6 28.6
    No 65939 (80.8) 118050 (80.0)
    Type I 1311 (1.6) 2244 (1.5)
    Type II 14397 (17.6) 27337 (18.5)
Hypertension1 2.3 63793 (57.1) 2.1 113641 (56.2)
Atrial fibrillation/flutter1 0.7 59692 (52.6) 0.6 106801 (52.0)
Lung disease1 2.1 20034 (17.9) 2.0 35327 (17.4)
Valve disease1 3.5 22501 (20.4) 3.5 40839 (20.5)
Dilated cardiomyopathy1 4.6 11420 (10.5) 4.6 25229 (12.8)
Revascularization1 3.0 29922 (27.0) 3.2 57913 (28.9)
Valve surgery1 2.1 7379 (6.6) 2.3 13971 (6.9)
ECG rythm1 7.0 6.4
    Sinus 53466 (50.3) 97645 (50.5)
    Atrial fibrillation 40427 (38.0) 71468 (36.9)
    PM/Other 12485 (11.7) 24361 (12.6)
Follow-up referral HF nurse clinic1 9.6 55145 (53.3) 7.0 118717 (61.8)
Follow-up referral speciality1 8.0 5.8
    Hospital 62428 (59.3) 124411 (63.9)
    Primary care 38790 (36.9) 64273 (33.0)
    Other 4034 (3.8) 6012 (3.1)
Follow-up referral speciality Hospital1 8.0 62428 (59.3) 5.8 124411 (63.9)
QoL EQ-5D1 69.5 70.0 [50.0, 80.0] 68.5 70.0 [50.0, 80.0]
QoL EQ-5D1 69.5 68.5
    0-25 1646 (4.7) 2924 (4.5)
    26-50 8723 (25.0) 15867 (24.4)
    51-75 14062 (40.3) 26745 (41.1)
    76-100 10424 (29.9) 19531 (30.0)
Fatigue1 61.5 60.2
    At rest 2682 (6.1) 4430 (5.4)
    At moderate effort 12247 (27.8) 22021 (26.8)
    At more than moderate effort 21839 (49.6) 42634 (51.8)
    Unaffected 7239 (16.4) 13191 (16.0)
Out of breath1 61.1 59.8
    At rest 1491 (3.3) 2357 (2.8)
    At moderate effort 13459 (30.2) 24267 (29.2)
    At more than moderate effort 22848 (51.3) 44385 (53.4)
    Unaffected 6750 (15.2) 12111 (14.6)
Mobilty1 60.9 59.8
    Bedridden 579 (1.3) 820 (1.0)
    Some problem 20179 (45.2) 35933 (43.2)
    No problem 23931 (53.6) 46384 (55.8)
Hygiene1 61.2 60.0
    Can't wash and clothe 925 (2.1) 1292 (1.6)
    Some problem 5234 (11.8) 8468 (10.2)
    No problem 38230 (86.1) 72892 (88.2)
Main activities1 61.4 60.2
    Can't do 2276 (5.2) 3616 (4.4)
    Some problem 12052 (27.3) 21732 (26.4)
    No problem 29829 (67.6) 56887 (69.2)
Pain1 62.7 61.4
    Severe 2712 (6.4) 4743 (6.0)
    Moderate 19140 (44.9) 35708 (44.8)
    None 20780 (48.7) 39256 (49.3)
Anxiety/Depression1 64.2 62.9
    Severe 1835 (4.5) 3155 (4.1)
    Moderate 15017 (36.7) 28028 (36.5)
    None 24085 (58.8) 45555 (59.4)
BMI (kg/m²)1 38.2 26.3 [23.3, 30.2] 32.6 26.7 [23.6, 30.5]
BMI (kg/m²) ≥301 38.2 18566 (26.3) 32.5 39078 (28.0)
Age (years)1 0.0 0.0
    <70 30727 (26.9) 62624 (30.3) 96349 (22.8) 125509 (32.3) 190209 (24.3)
    70-80 39316 (34.4) 75073 (36.3) 129929 (30.7) 148752 (38.3) 254503 (32.5)
    >80 44332 (38.8) 68937 (33.4) 196598 (46.5) 114577 (29.5) 337510 (43.1)
Previous HFH < 1 year12 0.0 66506 (58.1) 0.0 115625 (56.0) 287370 (68.0) 0 (0.0) 0 (0.0)
Atrial fibrillation/flutter12 0.0 67696 (59.2) 0.0 120790 (58.5) 186607 (44.1) 26061 (6.7) 51634 (6.6)
IHD12 0.0 61627 (53.9) 0.0 113161 (54.8) 191730 (45.3) 50542 (13.0) 105655 (13.5)
Hypertension12 0.0 77441 (67.7) 0.0 137681 (66.6) 218197 (51.6) 83447 (21.5) 148166 (18.9)
Diabetes12 0.0 31118 (27.2) 0.0 57402 (27.8) 96482 (22.8) 31969 (8.2) 57754 (7.4)
Valve disease12 0.0 30732 (26.9) 0.0 55720 (27.0) 64165 (15.2) 7756 (2.0) 13740 (1.8)
Country of birth3 0.0 0.0
    Sweden 98473 (86.1) 176223 (85.3) 370296 (87.6) 338660 (87.1) 695921 (89.0)
    Europe 12364 (10.8) 23606 (11.4) 42098 (10.0) 37013 (9.5) 66666 (8.5)
    Other 3536 (3.1) 6802 (3.3) 10471 (2.5) 13134 (3.4) 19586 (2.5)
Children3 0.0 95795 (83.8) 0.0 172849 (83.6) 350314 (82.8) 329013 (84.6) 654789 (83.7)
Marital status Single/widowed/divorced3 0.1 61993 (54.2) 0.1 108224 (52.4) 246424 (58.4) 183019 (47.1) 415532 (53.2)
Family type Living alone3 0.1 57758 (50.5) 0.1 99991 (48.4) 232291 (55.0) 168464 (43.4) 391402 (50.1)
Education3 2.1 2.1
    Compulsory school 50010 (44.7) 88400 (43.7) 206616 (51.1) 145477 (38.1) 345641 (46.0)
    Secondary school 43213 (38.6) 79798 (39.4) 140319 (34.7) 147189 (38.5) 263179 (35.0)
    University 18697 (16.7) 34143 (16.9) 57729 (14.3) 89221 (23.4) 142223 (18.9)
Disposable income (100 SEK)3 0.1 1534.0 [1226.0, 2041.0] 0.1 1545.0 [1236.0, 2076.0] 1365.0 [1055.0, 1783.0] 1653.0 [1269.0, 2478.0] 1408.0 [1061.0, 1963.0]
Duration of HF (days)2 0.0 303.0 [14.0, 1736.0] 0.0 343.0 [18.0, 1883.0] 0.0 [0.0, 101.0]
Time since last HF hospitalization (days)2 40.8 20.0 [0.0, 264.0] 40.4 22.0 [0.0, 287.0] 0.0 [0.0, 0.0]
Location2 0.0 0.0
    HF in-patient 29379 (25.7) 51246 (24.8) 287370 (68.0)
    Other in-patient 16270 (14.2) 24942 (12.1) 13696 (3.2)
    Out-patient 68726 (60.1) 130446 (63.1) 121810 (28.8)
Hypertension2 0.0 67327 (58.9) 0.0 118776 (57.5) 218197 (51.6) 83447 (21.5) 148166 (18.9)
Diabetes2 0.0 29925 (26.2) 0.0 54888 (26.6) 96482 (22.8) 31969 (8.2) 57754 (7.4)
Ischemic heart disease2 0.0 60454 (52.9) 0.0 110900 (53.7) 190114 (45.0) 50209 (12.9) 105218 (13.5)
Myocardial infarction2 0.0 44249 (38.7) 0.0 81357 (39.4) 130249 (30.8) 27019 (6.9) 54342 (6.9)
Angina pectoris2 0.0 22181 (19.4) 0.0 41455 (20.1) 77036 (18.2) 15463 (4.0) 35088 (4.5)
PCI2 0.0 21899 (19.1) 0.0 41645 (20.2) 47489 (11.2) 16445 (4.2) 23714 (3.0)
CABG2 0.0 28938 (25.3) 0.0 55861 (27.0) 65972 (15.6) 20000 (5.1) 29752 (3.8)
Dilated cardiomyopathy2 0.0 9953 (8.7) 0.0 22104 (10.7) 13639 (3.2) 0 (0.0) 0 (0.0)
Peripheral artery disease2 0.0 10968 (9.6) 0.0 18865 (9.1) 34563 (8.2) 10077 (2.6) 19198 (2.5)
Atrial fibrillation/flutter2 0.0 62870 (55.0) 0.0 111846 (54.1) 186607 (44.1) 26061 (6.7) 51634 (6.6)
Stroke2 0.0 18149 (15.9) 0.0 30719 (14.9) 70420 (16.7) 33721 (8.7) 77571 (9.9)
TIA2 0.0 4109 (3.6) 0.0 7105 (3.4) 15546 (3.7) 8388 (2.2) 17945 (2.3)
Stroke/TIA2 0.0 20666 (18.1) 0.0 35136 (17.0) 79946 (18.9) 39439 (10.1) 89741 (11.5)
Valvular disease2 0.0 23871 (20.9) 0.0 42582 (20.6) 64165 (15.2) 7756 (2.0) 13740 (1.8)
Renal failure2 0.0 19467 (17.0) 0.0 32496 (15.7) 49689 (11.8) 7026 (1.8) 11962 (1.5)
Hyperkalemia2 0.0 2500 (2.2) 0.0 4333 (2.1) 4706 (1.1) 602 (0.2) 1053 (0.1)
Hypokalemia2 0.0 3174 (2.8) 0.0 5136 (2.5) 9876 (2.3) 2081 (0.5) 4182 (0.5)
Dialysis2 0.0 1131 (1.0) 0.0 1863 (0.9) 4464 (1.1) 647 (0.2) 1036 (0.1)
COPD2 0.0 16169 (14.1) 0.0 28419 (13.8) 51011 (12.1) 10675 (2.7) 19835 (2.5)
Pneumonia/Flue/Respiratory infection2 0.0 42328 (37.0) 0.0 73936 (35.8) 151531 (35.8) 36286 (9.3) 72903 (9.3)
Liver disease2 0.0 2609 (2.3) 0.0 4680 (2.3) 7973 (1.9) 2683 (0.7) 4199 (0.5)
Obstructive sleep apnea2 0.0 4869 (4.3) 0.0 9503 (4.6) 10726 (2.5) 5483 (1.4) 7027 (0.9)
Dementia2 0.0 2998 (2.6) 0.0 3838 (1.9) 18772 (4.4) 13962 (3.6) 36467 (4.7)
Depression2 0.0 4464 (3.9) 0.0 7701 (3.7) 15492 (3.7) 8931 (2.3) 17266 (2.2)
Malignant cancer within 3 years2 0.0 15045 (13.2) 0.0 25958 (12.6) 54617 (12.9) 43057 (11.1) 79708 (10.2)
Muscoloskeletal/connective tissue diseases within 3 years2 0.0 37283 (32.6) 0.0 66206 (32.0) 124052 (29.3) 77639 (20.0) 137759 (17.6)
Alcohol abuse2 0.0 3654 (3.2) 0.0 6566 (3.2) 10900 (2.6) 5618 (1.4) 8427 (1.1)
Severe bleeding2 0.0 22922 (20.0) 0.0 39016 (18.9) 72037 (17.0) 26950 (6.9) 53017 (6.8)
Charlson Comorbidity Index2 0.0 3.0 [1.0, 4.0] 0.0 3.0 [1.0, 4.0] 3.0 [1.0, 4.0] 0.0 [0.0, 2.0] 0.0 [0.0, 2.0]
Charlson Comorbidity Index2 0.0 0.0
    0-1 29521 (25.8) 55409 (26.8) 115662 (27.4) 276348 (71.1) 569447 (72.8)
    2-3 42102 (36.8) 77627 (37.6) 171369 (40.5) 80492 (20.7) 157568 (20.1)
    4-7 34525 (30.2) 59881 (29.0) 112854 (26.7) 26414 (6.8) 46081 (5.9)
    ≥8 8227 (7.2) 13717 (6.6) 22991 (5.4) 5584 (1.4) 9126 (1.2)
Heart failure hospitalization2 0.0 31555 (27.6) 0.0 77994 (37.7) 145770 (34.5) 0 (0.0) 0 (0.0)
Number of heart failure hospitalizations2 0.0 0.0 [0.0, 1.0] 0.0 0.0 [0.0, 1.0] 0.0 [0.0, 1.0] 0.0 [0.0, 0.0] 0.0 [0.0, 0.0]
Any hospitalization2 0.0 79304 (69.3) 0.0 154397 (74.7) 320292 (75.7) 199583 (51.3) 478972 (61.2)
CV hospitalization2 0.0 52581 (46.0) 0.0 112733 (54.6) 226587 (53.6) 67618 (17.4) 172962 (22.1)
Non-CV hospitalization2 0.0 63308 (55.4) 0.0 123023 (59.5) 261438 (61.8) 177818 (45.7) 429948 (55.0)
Stroke/TIA hospitalization2 0.0 8457 (7.4) 0.0 16164 (7.8) 40004 (9.5) 28959 (7.4) 78911 (10.1)
Myocardial infarction hospitalization2 0.0 6029 (5.3) 0.0 12647 (6.1) 34612 (8.2) 10723 (2.8) 29969 (3.8)
Ischemic heart disease hospitalization2 0.0 10683 (9.3) 0.0 24304 (11.8) 56005 (13.2) 15725 (4.0) 41744 (5.3)
Ventricular fibrillation/tachycardia hospitalization2 0.0 1321 (1.2) 0.0 3953 (1.9) 4785 (1.1) 223 (0.1) 524 (0.1)
Pneumonia/Flue/Respiratory infection hospitalization2 0.0 19445 (17.0) 0.0 39431 (19.1) 89403 (21.1) 30443 (7.8) 79891 (10.2)
Pneumonia hospitalization2 0.0 12959 (11.3) 0.0 26420 (12.8) 58778 (13.9) 22892 (5.9) 60174 (7.7)
Renal failure hospitalization2 0.0 6471 (5.7) 0.0 13711 (6.6) 25296 (6.0) 4574 (1.2) 10094 (1.3)
Malignant cancer hospitalization2 0.0 8037 (7.0) 0.0 14449 (7.0) 35025 (8.3) 37816 (9.7) 91528 (11.7)
Severe bleeding hospitalization2 0.0 16292 (14.2) 0.0 32475 (15.7) 64957 (15.4) 33183 (8.5) 81045 (10.4)
Hyperkalemia hospitalization2 0.0 683 (0.6) 0.0 1715 (0.8) 2825 (0.7) 235 (0.1) 532 (0.1)
Hypokalemia hospitalization2 0.0 322 (0.3) 0.0 816 (0.4) 1345 (0.3) 542 (0.1) 1195 (0.2)
Syncope hospitalization2 0.0 2691 (2.4) 0.0 6094 (2.9) 12114 (2.9) 6400 (1.6) 17134 (2.2)
Trauma hospitalization2 0.0 14517 (12.7) 0.0 27837 (13.5) 65663 (15.5) 44297 (11.4) 130595 (16.7)
Coronary revascularization2 0.0 3708 (3.2) 0.0 8998 (4.4) 18924 (4.5) 8890 (2.3) 17394 (2.2)
Death2 0.0 64876 (56.7) 0.0 112286 (54.3) 300917 (71.2) 127556 (32.8) 406620 (52.0)
CV death2 0.0 38524 (33.7) 0.0 68541 (33.2) 178361 (42.2) 40123 (10.3) 145478 (18.6)
Non-CV death2 0.0 26352 (23.0) 0.0 43745 (21.2) 122556 (29.0) 87433 (22.5) 261142 (33.4)
Hospitalization or death Sudden cardiac death2 0.0 59 (0.1) 0.0 110 (0.1) 346 (0.1) 99 (0.0) 542 (0.1)
Composite CVD/HFH2 0.0 53843 (47.1) 0.0 106812 (51.7) 247007 (58.4) 40123 (10.3) 145478 (18.6)
Composite Death/HFH2 0.0 72271 (63.2) 0.0 132076 (63.9) 329180 (77.8) 127556 (32.8) 406620 (52.0)
Note:
\n Patients have different follow-up times, this means that outcomes can not be interpreted directly from the table.
\n Categorical variables are presented with n (%) and continuous variables with median [q1-q3].
\n1 Source: SwedeHF
\n2 Source: NPR
\n3 Source: SCB
\n\n`````\n:::\n:::\n", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": { + "include-in-header": [ + "\r\n\r\n" + ] + }, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_freeze/population/index/execute-results/html.json b/_freeze/population/index/execute-results/html.json new file mode 100644 index 0000000..f6328d7 --- /dev/null +++ b/_freeze/population/index/execute-results/html.json @@ -0,0 +1,14 @@ +{ + "hash": "db1d53d81fc38715f98bb764e904cc30", + "result": { + "markdown": "---\ntitle: Population\n---\n\n\n\n::: {.cell}\n\n:::\n\n\n## Patients registered in SwedeHF\n\nAll patients recorded in SwedeHF are included. \n\n----\n\n## Patients with HF from the National Patient Register\n\nPatients with an ICD-10 code for HF in main position in the National Patient Register (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761) starting from 2000-01-01 with no previous ICD-9/10 code for HF (I110 I130 I132 I255 I420 I423 1425 I426 I427 I428 I429 I43 I50 J81 K761 ICD-9: 414W 425E 425F 425G 425H 425W 425X 428) since 1987.\n\n----\n\n## HF-free controls\n\nFor each post in SwedeHF or the first date in the National Patient Register a set of controls was chosen by Statistics Sweden in a ratio of 2:1. Since a person can have more than one registered post in SwedeHF a patient can have more than 2 controls in total, up to 2 for each posts.\n\nEligible controls were persons without re-used Swedish personal identity numbers (PINs) and free of HF, defined either in the National Patient registry (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761, R570, ICD-9: 414W, 425E-H, 425W, 425X, 428) or SwedeHF, at the end of the year of the index date for the case and matched by gender, year of birth and county of residence at index. For posts with age ≥ 90 years, controls were only matched by gender and year of birth due to the smaller available number of controls.\n\nThe selection of controls was performed without replacement.\n\nA control was allowed to become a case after the year of the index date for the case.\n\nA full set of controls (n = 2) was not found for all cases:\n\n\n::: {.cell}\n::: {.cell-output-display}\n`````{=html}\n\n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
Population No controls Posts Unique patients
Case SwedeHF 0 3849 2156
Case SwedeHF 1 17210 7319
Case SwedeHF 2 185575 104900
Case NPR 0 19057 19057
Case NPR 1 26433 26433
Case NPR 2 377386 377386
\n\n`````\n:::\n:::\n\n\n----\n\n## Inclusion/exclusion criteria\n\n\n::: {.cell}\n::: {.cell-output-display}\n`````{=html}\n\n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n
Criteria Case SwedeHF Case NPR Control SwedeHF Control NPR
No of posts recieved 216652 471853 405913 802436
Exclude posts with duplicated index dates 216029
Exclude posts with with index date < 2000-01-01 216026 437182 405907 799666
Exclude posts with with index date > 2021-12-31 207290 426074 388928 785550
Exclude posts < 18 years 207277 424752 388903 782942
Exclude posts that are not present in SCB register 206875 423401 388903 782942
Exclude posts with reused PINs 206640 423026 388903 782942
Exclude posts censored end fu < index 206634 422876 388838 782222
Exclude controls without cases 206634 422876 388838 782222
Exclude posts with end of follow-up <= index date (died in hospital) 203425
Unique patients 112423
\n\n`````\n:::\n:::", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": {}, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_freeze/site_libs/clipboard/clipboard.min.js b/_freeze/site_libs/clipboard/clipboard.min.js new file mode 100644 index 0000000..1103f81 --- /dev/null +++ b/_freeze/site_libs/clipboard/clipboard.min.js @@ -0,0 +1,7 @@ +/*! + * clipboard.js v2.0.11 + * https://clipboardjs.com/ + * + * Licensed MIT © Zeno Rocha + */ +!function(t,e){"object"==typeof exports&&"object"==typeof module?module.exports=e():"function"==typeof define&&define.amd?define([],e):"object"==typeof exports?exports.ClipboardJS=e():t.ClipboardJS=e()}(this,function(){return n={686:function(t,e,n){"use strict";n.d(e,{default:function(){return b}});var e=n(279),i=n.n(e),e=n(370),u=n.n(e),e=n(817),r=n.n(e);function c(t){try{return document.execCommand(t)}catch(t){return}}var a=function(t){t=r()(t);return c("cut"),t};function o(t,e){var n,o,t=(n=t,o="rtl"===document.documentElement.getAttribute("dir"),(t=document.createElement("textarea")).style.fontSize="12pt",t.style.border="0",t.style.padding="0",t.style.margin="0",t.style.position="absolute",t.style[o?"right":"left"]="-9999px",o=window.pageYOffset||document.documentElement.scrollTop,t.style.top="".concat(o,"px"),t.setAttribute("readonly",""),t.value=n,t);return e.container.appendChild(t),e=r()(t),c("copy"),t.remove(),e}var f=function(t){var e=1\n \n\n\n
Patients (last post)
\n
Posts
\n\n\n\n\n \n Variable \n % missing \n SwedeHF \n % missing \n SwedeHF \n Case NPR \n Control SwedeHF \n Control NPR \n \n \n\n \n n \n \n 114375 \n \n 206634 \n 422876 \n 388838 \n 782222 \n \n \n ncontrols \n 0.0 \n 2.0 [2.0, 2.0] \n 0.0 \n 2.0 [2.0, 2.0] \n 2.0 [2.0, 2.0] \n 0.0 [0.0, 0.0] \n 0.0 [0.0, 0.0] \n \n \n Time in hospital at index hospitalization (days)1 \n 60.9 \n 5.0 [3.0, 9.0] \n 63.8 \n 5.0 [3.0, 9.0] \n \n \n \n \n \n Index year1 \n 0.0 \n 2015.0 [2010.0, 2019.0] \n 0.0 \n 2014.0 [2010.0, 2018.0] \n 2011.0 [2005.0, 2016.0] \n 2014.0 [2010.0, 2018.0] \n 2010.0 [2005.0, 2016.0] \n \n \n Type of visit Index1 \n 0.0 \n 68651 (60.0) \n 0.0 \n 115634 (56.0) \n \n \n \n \n \n LVEF (%)1 \n 85.6 \n 40.0 [30.0, 50.0] \n 86.5 \n 39.0 [30.0, 45.0] \n \n \n \n \n \n LVEF (%)1 \n 19.9 \n \n 17.1 \n \n \n \n \n \n \n     ≥50 \n \n 23497 (25.7) \n \n 38003 (22.2) \n \n \n \n \n \n     40-49 \n \n 22033 (24.1) \n \n 39894 (23.3) \n \n \n \n \n \n     30-39 \n \n 23867 (26.1) \n \n 46520 (27.2) \n \n \n \n \n \n     <30 \n \n 22177 (24.2) \n \n 46790 (27.3) \n \n \n \n \n \n LVEF (%)1 \n 19.9 \n \n 17.1 \n \n \n \n \n \n \n     HFrEF \n \n 46044 (50.3) \n \n 93310 (54.5) \n \n \n \n \n \n     HFmrEF \n \n 22033 (24.1) \n \n 39894 (23.3) \n \n \n \n \n \n     HFpEF \n \n 23497 (25.7) \n \n 38003 (22.2) \n \n \n \n \n \n Sex Male1 \n 0.0 \n 70503 (61.6) \n 0.0 \n 132380 (64.1) \n 226402 (53.5) \n 244109 (62.8) \n 408993 (52.3) \n \n \n Age (years)1 \n 0.0 \n 77.0 [69.0, 84.0] \n 0.0 \n 76.0 [67.0, 83.0] \n 80.0 [71.0, 86.0] \n 75.0 [67.0, 82.0] \n 79.0 [70.0, 85.0] \n \n \n Civil status Single1 \n 27.9 \n 36905 (44.8) \n 27.5 \n 63189 (42.2) \n \n \n \n \n \n Living conditions Own home1 \n 44.5 \n 59898 (94.4) \n 44.4 \n 110190 (95.8) \n \n \n \n \n \n Location In-patient1 \n 0.0 \n 44750 (39.1) \n 0.0 \n 74851 (36.2) \n \n \n \n \n \n Smoking1 \n 26.9 \n \n 23.3 \n \n \n \n \n \n \n     Current \n \n 9116 (10.9) \n \n 17267 (10.9) \n \n \n \n \n \n     Former \n \n 36685 (43.9) \n \n 70920 (44.8) \n \n \n \n \n \n     Never \n \n 37769 (45.2) \n \n 70225 (44.3) \n \n \n \n \n \n Smoking1 \n 26.9 \n 9116 (10.9) \n 23.3 \n 17267 (10.9) \n \n \n \n \n \n Alcohol Risk1 \n 42.5 \n 2836 (4.3) \n 38.9 \n 5179 (4.1) \n \n \n \n \n \n Duration of HF ≥6mo1 \n 2.8 \n 68600 (61.7) \n 2.5 \n 124933 (62.0) \n \n \n \n \n \n Primary etiology1 \n 40.9 \n \n 40.3 \n \n \n \n \n \n \n     DCM \n \n 4597 (6.8) \n \n 10169 (8.2) \n \n \n \n \n \n     Heart valve disease \n \n 5387 (8.0) \n \n 9187 (7.4) \n \n \n \n \n \n     Hypertension \n \n 17917 (26.5) \n \n 31520 (25.5) \n \n \n \n \n \n     IHD \n \n 26407 (39.1) \n \n 50168 (40.6) \n \n \n \n \n \n     Known alcoholic cardiomyopathy \n \n 467 (0.7) \n \n 898 (0.7) \n \n \n \n \n \n     Other \n \n 12828 (19.0) \n \n 21510 (17.4) \n \n \n \n \n \n NYHA class1 \n 30.0 \n \n 26.1 \n \n \n \n \n \n \n     I \n \n 10233 (12.8) \n \n 17921 (11.7) \n \n \n \n \n \n     II \n \n 37273 (46.5) \n \n 73193 (48.0) \n \n \n \n \n \n     III \n \n 29222 (36.5) \n \n 56325 (36.9) \n \n \n \n \n \n     IV \n \n 3390 (4.2) \n \n 5173 (3.4) \n \n \n \n \n \n NYHA class III-IV1 \n 30.0 \n 32612 (40.7) \n 26.1 \n 61498 (40.3) \n \n \n \n \n \n Killip class1 \n 94.4 \n \n 95.8 \n \n \n \n \n \n \n     Chock or hypertension \n \n 17 (0.3) \n \n 27 (0.3) \n \n \n \n \n \n     Edema \n \n 160 (2.5) \n \n 217 (2.5) \n \n \n \n \n \n     No signs of HF \n \n 2904 (45.4) \n \n 4128 (47.3) \n \n \n \n \n \n     Rales or crackles \n \n 3310 (51.8) \n \n 4349 (49.9) \n \n \n \n \n \n Weight (kg)1 \n 12.9 \n 77.4 [66.0, 90.0] \n 11.8 \n 79.0 [67.8, 91.5] \n \n \n \n \n \n Weight at admission/visit (kg)1 \n 32.7 \n 78.0 [66.4, 90.4] \n 37.2 \n 79.0 [68.0, 91.8] \n \n \n \n \n \n Weight at discharge   (hospitalized patients) (kg)1 \n 94.8 \n 75.5 [63.5, 88.7] \n 96.1 \n 77.0 [65.0, 90.0] \n \n \n \n \n \n Height (cm)1 \n 32.0 \n 172.0 [164.0, 179.0] \n 26.0 \n 172.0 [165.0, 179.0] \n \n \n \n \n \n Systolic blood pressure (mmHg)1 \n 3.9 \n 125.0 [110.0, 140.0] \n 3.3 \n 125.0 [110.0, 140.0] \n \n \n \n \n \n Systolic blood pressure at admission/visit (mmHg)1 \n 25.0 \n 126.0 [112.0, 140.0] \n 30.4 \n 125.0 [112.0, 140.0] \n \n \n \n \n \n Systolic blood pressure at discharge   (hospitalized patients) (mmHg)1 \n 94.0 \n 125.0 [111.0, 140.0] \n 95.5 \n 125.0 [110.0, 140.0] \n \n \n \n \n \n Diastolic blood pressure (mmHg)1 \n 3.8 \n 70.0 [65.0, 80.0] \n 3.2 \n 70.0 [65.0, 80.0] \n \n \n \n \n \n Diastolic blood pressure at admission/visit (mmHg)1 \n 25.0 \n 72.0 [65.0, 80.0] \n 30.3 \n 72.0 [65.0, 80.0] \n \n \n \n \n \n Diastolic blood pressure at discharge   (hospitalized patients) (mmHg)1 \n 93.9 \n 72.0 [65.0, 80.0] \n 95.5 \n 72.0 [65.0, 80.0] \n \n \n \n \n \n Mean arterial pressure1 \n 3.8 \n 90.0 [81.7, 99.7] \n 3.2 \n 90.0 [81.7, 99.0] \n \n \n \n \n \n Mean arterial pressure >901 \n 3.8 \n 52421 (47.6) \n 3.2 \n 94489 (47.2) \n \n \n \n \n \n Heart rate (beats/min)1 \n 6.5 \n 71.0 [63.0, 82.0] \n 5.7 \n 71.0 [63.0, 81.0] \n \n \n \n \n \n Heart rate at admission/visit (beats/min)1 \n 27.0 \n 72.0 [63.0, 83.0] \n 32.1 \n 71.0 [63.0, 82.0] \n \n \n \n \n \n Heart rate at discharge   (hospitalized patients) (beats/min)1 \n 94.2 \n 74.0 [65.0, 85.0] \n 95.6 \n 74.0 [65.0, 85.0] \n \n \n \n \n \n Heart rate (beats/min) >701 \n 6.5 \n 55096 (51.5) \n 5.7 \n 98701 (50.7) \n \n \n \n \n \n Hemoglobin (g/L)1 \n 8.2 \n 131.0 [118.0, 143.0] \n 8.1 \n 132.0 [120.0, 144.0] \n \n \n \n \n \n Hemoglobin at admission/visit (g/L)1 \n 29.2 \n 132.0 [119.0, 144.0] \n 34.7 \n 133.0 [120.0, 145.0] \n \n \n \n \n \n Hemoglobin at discharge   (hospitalized patients) (g/L)1 \n 96.3 \n 119.0 [106.0, 135.0] \n 97.2 \n 122.0 [107.0, 137.0] \n \n \n \n \n \n Anemia1 \n 8.2 \n 39397 (37.5) \n 8.1 \n 66947 (35.2) \n \n \n \n \n \n Potassium (mmol/L)1 \n 19.9 \n 4.2 [3.9, 4.5] \n 18.7 \n 4.2 [3.9, 4.5] \n \n \n \n \n \n Potassium at admission/visit (mmol/L)1 \n 36.0 \n 4.2 [3.9, 4.5] \n 39.9 \n 4.2 [3.9, 4.5] \n \n \n \n \n \n Potassium at discharge   (hospitalized patients) (mmol/L)1 \n 94.8 \n 4.0 [3.7, 4.3] \n 96.1 \n 4.0 [3.7, 4.3] \n \n \n \n \n \n Potassium (mmol/L)1 \n 19.9 \n \n 18.7 \n \n \n \n \n \n \n     Normakalemia \n \n 83777 (91.5) \n \n 155018 (92.3) \n \n \n \n \n \n     Hypokalemia \n \n 4060 (4.4) \n \n 6444 (3.8) \n \n \n \n \n \n     Hyperkalemia \n \n 3725 (4.1) \n \n 6446 (3.8) \n \n \n \n \n \n Sodium (mmol/l)1 \n 35.0 \n 140.0 [138.0, 142.0] \n 35.1 \n 140.0 [138.0, 142.0] \n \n \n \n \n \n Sodium at admission/visit (mmol/l)1 \n 46.8 \n 140.0 [138.0, 142.0] \n 50.5 \n 140.0 [138.0, 142.0] \n \n \n \n \n \n Sodium at discharge   (hospitalized patients) (mmol/l)1 \n 95.0 \n 140.0 [138.0, 142.0] \n 96.2 \n 140.0 [138.0, 142.0] \n \n \n \n \n \n Creatinine (µmol/L)1 \n 3.2 \n 97.0 [79.0, 126.0] \n 2.9 \n 97.0 [79.0, 124.0] \n \n \n \n \n \n Creatinine at admission/visit (µmol/L)1 \n 24.6 \n 95.0 [78.0, 122.0] \n 30.2 \n 94.0 [77.0, 119.0] \n \n \n \n \n \n Creatinine at discharge   (hospitalized patients) (µmol/L)1 \n 94.8 \n 100.0 [78.0, 133.0] \n 96.1 \n 97.0 [78.0, 128.0] \n \n \n \n \n \n eGFR (mL/min/1.73 m²)1 \n 2.9 \n 62.7 [44.8, 82.7] \n 2.7 \n 64.0 [46.4, 83.4] \n \n \n \n \n \n eGFR (mL/min/1.73 m²) <601 \n 2.9 \n 51262 (46.2) \n 2.7 \n 88931 (44.2) \n \n \n \n \n \n NT-proBNP (pg/ml)1 \n 44.7 \n 2066.0 [812.0, 4950.0] \n 44.1 \n 2000.0 [810.0, 4563.0] \n \n \n \n \n \n NT-proBNP at admission/visit (pg/ml)1 \n 55.0 \n 1971.0 [770.0, 4633.0] \n 57.6 \n 1900.0 [765.0, 4296.0] \n \n \n \n \n \n NT-proBNP at discharge   (hospitalized patients) (pg/ml)1 \n 97.9 \n 3660.0 [1657.0, 8656.5] \n 98.4 \n 3380.0 [1574.0, 7652.5] \n \n \n \n \n \n BNP (pg/ml)1 \n 95.6 \n 580.0 [219.0, 1335.5] \n 95.1 \n 527.0 [202.0, 1230.0] \n \n \n \n \n \n Transferrin (%)1 \n 89.7 \n 24.0 [17.0, 32.0] \n 90.5 \n 24.0 [17.0, 33.0] \n \n \n \n \n \n Ferritin (µg/l)1 \n 87.9 \n 142.0 [71.0, 264.0] \n 88.8 \n 142.0 [71.0, 262.0] \n \n \n \n \n \n QRS width (ms)1 \n 22.3 \n 104.0 [90.0, 132.0] \n 22.2 \n 106.0 [92.0, 136.0] \n \n \n \n \n \n Left Bundle Branch Block (LBBB)1 \n 21.7 \n 15800 (17.6) \n 21.7 \n 30529 (18.9) \n \n \n \n \n \n Loop diuretic IV1 \n 81.3 \n 5479 (25.5) \n 82.3 \n 7554 (20.6) \n \n \n \n \n \n Ferric carboxymaltose IV1 \n 57.2 \n 2501 (5.1) \n 59.6 \n 3917 (4.7) \n \n \n \n \n \n Ferric carboxymaltose IV dose (mg)1 \n 97.9 \n 1000.0 [1000.0, 1000.0] \n 98.2 \n 1000.0 [1000.0, 1000.0] \n \n \n \n \n \n Unplanned inotrope support1 \n 39.4 \n 1356 (2.0) \n 40.0 \n 3640 (2.9) \n \n \n \n \n \n Diuretic1 \n 0.6 \n 86951 (76.5) \n 0.5 \n 158572 (77.1) \n \n \n \n \n \n Loop diuretic1 \n 27.4 \n 60440 (72.8) \n 27.8 \n 108999 (73.1) \n \n \n \n \n \n Loop diuretic substance1 \n 72.9 \n \n 75.5 \n \n \n \n \n \n \n     Bumetanid \n \n 230 (0.7) \n \n 339 (0.7) \n \n \n \n \n \n     Furosemid \n \n 30618 (98.8) \n \n 50174 (98.9) \n \n \n \n \n \n     Toresamid \n \n 127 (0.4) \n \n 203 (0.4) \n \n \n \n \n \n Loop diuretic dose (mg/24h)1 \n 54.9 \n 40.0 [40.0, 80.0] \n 54.6 \n 40.0 [40.0, 80.0] \n \n \n \n \n \n Loop diuretic usage When necessary1 \n 47.3 \n 11615 (19.3) \n 47.4 \n 20892 (19.2) \n \n \n \n \n \n ACEi1 \n 0.6 \n 54926 (48.3) \n 0.4 \n 104596 (50.8) \n \n \n \n \n \n ACEi dose (mg/24h)1 \n 52.1 \n 10.0 [5.0, 15.0] \n 49.5 \n 10.0 [5.0, 15.0] \n \n \n \n \n \n ARB1 \n 1.1 \n 30970 (27.4) \n 0.9 \n 59400 (29.0) \n \n \n \n \n \n ARB dose (mg/24h)1 \n 73.0 \n 32.0 [15.0, 50.0] \n 71.3 \n 32.0 [12.5, 50.0] \n \n \n \n \n \n ARNi1 \n 56.0 \n 6960 (13.8) \n 58.6 \n 11611 (13.6) \n \n \n \n \n \n ACEi/ARB/ARNi1 \n 1.3 \n 91155 (80.7) \n 1.1 \n 172045 (84.1) \n \n \n \n \n \n Beta-blocker1 \n 0.5 \n 98019 (86.1) \n 0.4 \n 180675 (87.8) \n \n \n \n \n \n Beta-blocker dose (mg/24h)1 \n 14.5 \n 25.0 [7.5, 100.0] \n 12.8 \n 25.0 [7.5, 100.0] \n \n \n \n \n \n MRA1 \n 0.9 \n 42376 (37.4) \n 0.6 \n 79343 (38.6) \n \n \n \n \n \n MRA dose (mg/24h)1 \n 75.3 \n 25.0 [25.0, 25.0] \n 75.5 \n 25.0 [25.0, 25.0] \n \n \n \n \n \n Digoxin1 \n 0.6 \n 14862 (13.1) \n 0.4 \n 27435 (13.3) \n \n \n \n \n \n Platelet inhibitor1 \n 0.6 \n 44577 (39.2) \n 0.5 \n 80458 (39.1) \n \n \n \n \n \n Oral anticoagulant1 \n 0.6 \n 52927 (46.6) \n 0.5 \n 99517 (48.4) \n \n \n \n \n \n Statin1 \n 0.5 \n 52912 (46.5) \n 0.4 \n 101529 (49.3) \n \n \n \n \n \n Nitrate1 \n 0.7 \n 15034 (13.2) \n 0.5 \n 26719 (13.0) \n \n \n \n \n \n SGLT2i1 \n 91.7 \n 2022 (21.3) \n 94.9 \n 2186 (20.9) \n \n \n \n \n \n SGLT2i dose (mg/24h)1 \n 98.2 \n 10.0 [10.0, 10.0] \n 98.9 \n 10.0 [10.0, 10.0] \n \n \n \n \n \n Sinus node inhibitor1 \n 58.3 \n 248 (0.5) \n 61.3 \n 473 (0.6) \n \n \n \n \n \n Device therapy1 \n 1.4 \n \n 1.7 \n \n \n \n \n \n \n     No \n \n 93068 (82.5) \n \n 164078 (80.8) \n \n \n \n \n \n     Pacemaker \n \n 10685 (9.5) \n \n 19200 (9.5) \n \n \n \n \n \n     CRT-P \n \n 2154 (1.9) \n \n 4370 (2.2) \n \n \n \n \n \n     CRT-D \n \n 3369 (3.0) \n \n 7741 (3.8) \n \n \n \n \n \n     ICD \n \n 3524 (3.1) \n \n 7669 (3.8) \n \n \n \n \n \n Device therapy CRT/ICD1 \n 1.4 \n 9047 (8.0) \n 1.7 \n 19780 (9.7) \n \n \n \n \n \n Chest X-ray1 \n 37.0 \n \n 35.2 \n \n \n \n \n \n \n     No \n \n 18770 (26.0) \n \n 36050 (26.9) \n \n \n \n \n \n     Normal \n \n 17955 (24.9) \n \n 32987 (24.6) \n \n \n \n \n \n     Pulmonary congestion \n \n 9713 (13.5) \n \n 16557 (12.4) \n \n \n \n \n \n     Cardiomegaly \n \n 11934 (16.6) \n \n 23395 (17.5) \n \n \n \n \n \n     Pulmonary congestion & cardiomegaly \n \n 13718 (19.0) \n \n 24955 (18.6) \n \n \n \n \n \n Diabetes1 \n 10.3 \n 17712 (17.3) \n 9.7 \n 34450 (18.5) \n \n \n \n \n \n Diabetes1 \n 28.6 \n \n 28.6 \n \n \n \n \n \n \n     No \n \n 65939 (80.8) \n \n 118050 (80.0) \n \n \n \n \n \n     Type I \n \n 1311 (1.6) \n \n 2244 (1.5) \n \n \n \n \n \n     Type II \n \n 14397 (17.6) \n \n 27337 (18.5) \n \n \n \n \n \n Hypertension1 \n 2.3 \n 63793 (57.1) \n 2.1 \n 113641 (56.2) \n \n \n \n \n \n Atrial fibrillation/flutter1 \n 0.7 \n 59692 (52.6) \n 0.6 \n 106801 (52.0) \n \n \n \n \n \n Lung disease1 \n 2.1 \n 20034 (17.9) \n 2.0 \n 35327 (17.4) \n \n \n \n \n \n Valve disease1 \n 3.5 \n 22501 (20.4) \n 3.5 \n 40839 (20.5) \n \n \n \n \n \n Dilated cardiomyopathy1 \n 4.6 \n 11420 (10.5) \n 4.6 \n 25229 (12.8) \n \n \n \n \n \n Revascularization1 \n 3.0 \n 29922 (27.0) \n 3.2 \n 57913 (28.9) \n \n \n \n \n \n Valve surgery1 \n 2.1 \n 7379 (6.6) \n 2.3 \n 13971 (6.9) \n \n \n \n \n \n ECG rythm1 \n 7.0 \n \n 6.4 \n \n \n \n \n \n \n     Sinus \n \n 53466 (50.3) \n \n 97645 (50.5) \n \n \n \n \n \n     Atrial fibrillation \n \n 40427 (38.0) \n \n 71468 (36.9) \n \n \n \n \n \n     PM/Other \n \n 12485 (11.7) \n \n 24361 (12.6) \n \n \n \n \n \n Follow-up referral HF nurse clinic1 \n 9.6 \n 55145 (53.3) \n 7.0 \n 118717 (61.8) \n \n \n \n \n \n Follow-up referral speciality1 \n 8.0 \n \n 5.8 \n \n \n \n \n \n \n     Hospital \n \n 62428 (59.3) \n \n 124411 (63.9) \n \n \n \n \n \n     Primary care \n \n 38790 (36.9) \n \n 64273 (33.0) \n \n \n \n \n \n     Other \n \n 4034 (3.8) \n \n 6012 (3.1) \n \n \n \n \n \n Follow-up referral speciality Hospital1 \n 8.0 \n 62428 (59.3) \n 5.8 \n 124411 (63.9) \n \n \n \n \n \n QoL EQ-5D1 \n 69.5 \n 70.0 [50.0, 80.0] \n 68.5 \n 70.0 [50.0, 80.0] \n \n \n \n \n \n QoL EQ-5D1 \n 69.5 \n \n 68.5 \n \n \n \n \n \n \n     0-25 \n \n 1646 (4.7) \n \n 2924 (4.5) \n \n \n \n \n \n     26-50 \n \n 8723 (25.0) \n \n 15867 (24.4) \n \n \n \n \n \n     51-75 \n \n 14062 (40.3) \n \n 26745 (41.1) \n \n \n \n \n \n     76-100 \n \n 10424 (29.9) \n \n 19531 (30.0) \n \n \n \n \n \n Fatigue1 \n 61.5 \n \n 60.2 \n \n \n \n \n \n \n     At rest \n \n 2682 (6.1) \n \n 4430 (5.4) \n \n \n \n \n \n     At moderate effort \n \n 12247 (27.8) \n \n 22021 (26.8) \n \n \n \n \n \n     At more than moderate effort \n \n 21839 (49.6) \n \n 42634 (51.8) \n \n \n \n \n \n     Unaffected \n \n 7239 (16.4) \n \n 13191 (16.0) \n \n \n \n \n \n Out of breath1 \n 61.1 \n \n 59.8 \n \n \n \n \n \n \n     At rest \n \n 1491 (3.3) \n \n 2357 (2.8) \n \n \n \n \n \n     At moderate effort \n \n 13459 (30.2) \n \n 24267 (29.2) \n \n \n \n \n \n     At more than moderate effort \n \n 22848 (51.3) \n \n 44385 (53.4) \n \n \n \n \n \n     Unaffected \n \n 6750 (15.2) \n \n 12111 (14.6) \n \n \n \n \n \n Mobilty1 \n 60.9 \n \n 59.8 \n \n \n \n \n \n \n     Bedridden \n \n 579 (1.3) \n \n 820 (1.0) \n \n \n \n \n \n     Some problem \n \n 20179 (45.2) \n \n 35933 (43.2) \n \n \n \n \n \n     No problem \n \n 23931 (53.6) \n \n 46384 (55.8) \n \n \n \n \n \n Hygiene1 \n 61.2 \n \n 60.0 \n \n \n \n \n \n \n     Can't wash and clothe \n \n 925 (2.1) \n \n 1292 (1.6) \n \n \n \n \n \n     Some problem \n \n 5234 (11.8) \n \n 8468 (10.2) \n \n \n \n \n \n     No problem \n \n 38230 (86.1) \n \n 72892 (88.2) \n \n \n \n \n \n Main activities1 \n 61.4 \n \n 60.2 \n \n \n \n \n \n \n     Can't do \n \n 2276 (5.2) \n \n 3616 (4.4) \n \n \n \n \n \n     Some problem \n \n 12052 (27.3) \n \n 21732 (26.4) \n \n \n \n \n \n     No problem \n \n 29829 (67.6) \n \n 56887 (69.2) \n \n \n \n \n \n Pain1 \n 62.7 \n \n 61.4 \n \n \n \n \n \n \n     Severe \n \n 2712 (6.4) \n \n 4743 (6.0) \n \n \n \n \n \n     Moderate \n \n 19140 (44.9) \n \n 35708 (44.8) \n \n \n \n \n \n     None \n \n 20780 (48.7) \n \n 39256 (49.3) \n \n \n \n \n \n Anxiety/Depression1 \n 64.2 \n \n 62.9 \n \n \n \n \n \n \n     Severe \n \n 1835 (4.5) \n \n 3155 (4.1) \n \n \n \n \n \n     Moderate \n \n 15017 (36.7) \n \n 28028 (36.5) \n \n \n \n \n \n     None \n \n 24085 (58.8) \n \n 45555 (59.4) \n \n \n \n \n \n BMI (kg/m²)1 \n 38.2 \n 26.3 [23.3, 30.2] \n 32.6 \n 26.7 [23.6, 30.5] \n \n \n \n \n \n BMI (kg/m²) ≥301 \n 38.2 \n 18566 (26.3) \n 32.5 \n 39078 (28.0) \n \n \n \n \n \n Age (years)1 \n 0.0 \n \n 0.0 \n \n \n \n \n \n \n     <70 \n \n 30727 (26.9) \n \n 62624 (30.3) \n 96349 (22.8) \n 125509 (32.3) \n 190209 (24.3) \n \n \n     70-80 \n \n 39316 (34.4) \n \n 75073 (36.3) \n 129929 (30.7) \n 148752 (38.3) \n 254503 (32.5) \n \n \n     >80 \n \n 44332 (38.8) \n \n 68937 (33.4) \n 196598 (46.5) \n 114577 (29.5) \n 337510 (43.1) \n \n \n Previous HFH < 1 year12 \n 0.0 \n 66506 (58.1) \n 0.0 \n 115625 (56.0) \n 287370 (68.0) \n 0 (0.0) \n 0 (0.0) \n \n \n Atrial fibrillation/flutter12 \n 0.0 \n 67696 (59.2) \n 0.0 \n 120790 (58.5) \n 186607 (44.1) \n 26061 (6.7) \n 51634 (6.6) \n \n \n IHD12 \n 0.0 \n 61627 (53.9) \n 0.0 \n 113161 (54.8) \n 191730 (45.3) \n 50542 (13.0) \n 105655 (13.5) \n \n \n Hypertension12 \n 0.0 \n 77441 (67.7) \n 0.0 \n 137681 (66.6) \n 218197 (51.6) \n 83447 (21.5) \n 148166 (18.9) \n \n \n Diabetes12 \n 0.0 \n 31118 (27.2) \n 0.0 \n 57402 (27.8) \n 96482 (22.8) \n 31969 (8.2) \n 57754 (7.4) \n \n \n Valve disease12 \n 0.0 \n 30732 (26.9) \n 0.0 \n 55720 (27.0) \n 64165 (15.2) \n 7756 (2.0) \n 13740 (1.8) \n \n \n Country of birth3 \n 0.0 \n \n 0.0 \n \n \n \n \n \n \n     Sweden \n \n 98473 (86.1) \n \n 176223 (85.3) \n 370296 (87.6) \n 338660 (87.1) \n 695921 (89.0) \n \n \n     Europe \n \n 12364 (10.8) \n \n 23606 (11.4) \n 42098 (10.0) \n 37013 (9.5) \n 66666 (8.5) \n \n \n     Other \n \n 3536 (3.1) \n \n 6802 (3.3) \n 10471 (2.5) \n 13134 (3.4) \n 19586 (2.5) \n \n \n Children3 \n 0.0 \n 95795 (83.8) \n 0.0 \n 172849 (83.6) \n 350314 (82.8) \n 329013 (84.6) \n 654789 (83.7) \n \n \n Marital status Single/widowed/divorced3 \n 0.1 \n 61993 (54.2) \n 0.1 \n 108224 (52.4) \n 246424 (58.4) \n 183019 (47.1) \n 415532 (53.2) \n \n \n Family type Living alone3 \n 0.1 \n 57758 (50.5) \n 0.1 \n 99991 (48.4) \n 232291 (55.0) \n 168464 (43.4) \n 391402 (50.1) \n \n \n Education3 \n 2.1 \n \n 2.1 \n \n \n \n \n \n \n     Compulsory school \n \n 50010 (44.7) \n \n 88400 (43.7) \n 206616 (51.1) \n 145477 (38.1) \n 345641 (46.0) \n \n \n     Secondary school \n \n 43213 (38.6) \n \n 79798 (39.4) \n 140319 (34.7) \n 147189 (38.5) \n 263179 (35.0) \n \n \n     University \n \n 18697 (16.7) \n \n 34143 (16.9) \n 57729 (14.3) \n 89221 (23.4) \n 142223 (18.9) \n \n \n Disposable income (100 SEK)3 \n 0.1 \n 1534.0 [1226.0, 2041.0] \n 0.1 \n 1545.0 [1236.0, 2076.0] \n 1365.0 [1055.0, 1783.0] \n 1653.0 [1269.0, 2478.0] \n 1408.0 [1061.0, 1963.0] \n \n \n Duration of HF (days)2 \n 0.0 \n 303.0 [14.0, 1736.0] \n 0.0 \n 343.0 [18.0, 1883.0] \n 0.0 [0.0, 101.0] \n \n \n \n \n Time since last HF hospitalization (days)2 \n 40.8 \n 20.0 [0.0, 264.0] \n 40.4 \n 22.0 [0.0, 287.0] \n 0.0 [0.0, 0.0] \n \n \n \n \n Location2 \n 0.0 \n \n 0.0 \n \n \n \n \n \n \n     HF in-patient \n \n 29379 (25.7) \n \n 51246 (24.8) \n 287370 (68.0) \n \n \n \n \n     Other in-patient \n \n 16270 (14.2) \n \n 24942 (12.1) \n 13696 (3.2) \n \n \n \n \n     Out-patient \n \n 68726 (60.1) \n \n 130446 (63.1) \n 121810 (28.8) \n \n \n \n \n Hypertension2 \n 0.0 \n 67327 (58.9) \n 0.0 \n 118776 (57.5) \n 218197 (51.6) \n 83447 (21.5) \n 148166 (18.9) \n \n \n Diabetes2 \n 0.0 \n 29925 (26.2) \n 0.0 \n 54888 (26.6) \n 96482 (22.8) \n 31969 (8.2) \n 57754 (7.4) \n \n \n Ischemic heart disease2 \n 0.0 \n 60454 (52.9) \n 0.0 \n 110900 (53.7) \n 190114 (45.0) \n 50209 (12.9) \n 105218 (13.5) \n \n \n Myocardial infarction2 \n 0.0 \n 44249 (38.7) \n 0.0 \n 81357 (39.4) \n 130249 (30.8) \n 27019 (6.9) \n 54342 (6.9) \n \n \n Angina pectoris2 \n 0.0 \n 22181 (19.4) \n 0.0 \n 41455 (20.1) \n 77036 (18.2) \n 15463 (4.0) \n 35088 (4.5) \n \n \n PCI2 \n 0.0 \n 21899 (19.1) \n 0.0 \n 41645 (20.2) \n 47489 (11.2) \n 16445 (4.2) \n 23714 (3.0) \n \n \n CABG2 \n 0.0 \n 28938 (25.3) \n 0.0 \n 55861 (27.0) \n 65972 (15.6) \n 20000 (5.1) \n 29752 (3.8) \n \n \n Dilated cardiomyopathy2 \n 0.0 \n 9953 (8.7) \n 0.0 \n 22104 (10.7) \n 13639 (3.2) \n 0 (0.0) \n 0 (0.0) \n \n \n Peripheral artery disease2 \n 0.0 \n 10968 (9.6) \n 0.0 \n 18865 (9.1) \n 34563 (8.2) \n 10077 (2.6) \n 19198 (2.5) \n \n \n Atrial fibrillation/flutter2 \n 0.0 \n 62870 (55.0) \n 0.0 \n 111846 (54.1) \n 186607 (44.1) \n 26061 (6.7) \n 51634 (6.6) \n \n \n Stroke2 \n 0.0 \n 18149 (15.9) \n 0.0 \n 30719 (14.9) \n 70420 (16.7) \n 33721 (8.7) \n 77571 (9.9) \n \n \n TIA2 \n 0.0 \n 4109 (3.6) \n 0.0 \n 7105 (3.4) \n 15546 (3.7) \n 8388 (2.2) \n 17945 (2.3) \n \n \n Stroke/TIA2 \n 0.0 \n 20666 (18.1) \n 0.0 \n 35136 (17.0) \n 79946 (18.9) \n 39439 (10.1) \n 89741 (11.5) \n \n \n Valvular disease2 \n 0.0 \n 23871 (20.9) \n 0.0 \n 42582 (20.6) \n 64165 (15.2) \n 7756 (2.0) \n 13740 (1.8) \n \n \n Renal failure2 \n 0.0 \n 19467 (17.0) \n 0.0 \n 32496 (15.7) \n 49689 (11.8) \n 7026 (1.8) \n 11962 (1.5) \n \n \n Hyperkalemia2 \n 0.0 \n 2500 (2.2) \n 0.0 \n 4333 (2.1) \n 4706 (1.1) \n 602 (0.2) \n 1053 (0.1) \n \n \n Hypokalemia2 \n 0.0 \n 3174 (2.8) \n 0.0 \n 5136 (2.5) \n 9876 (2.3) \n 2081 (0.5) \n 4182 (0.5) \n \n \n Dialysis2 \n 0.0 \n 1131 (1.0) \n 0.0 \n 1863 (0.9) \n 4464 (1.1) \n 647 (0.2) \n 1036 (0.1) \n \n \n COPD2 \n 0.0 \n 16169 (14.1) \n 0.0 \n 28419 (13.8) \n 51011 (12.1) \n 10675 (2.7) \n 19835 (2.5) \n \n \n Pneumonia/Flue/Respiratory infection2 \n 0.0 \n 42328 (37.0) \n 0.0 \n 73936 (35.8) \n 151531 (35.8) \n 36286 (9.3) \n 72903 (9.3) \n \n \n Liver disease2 \n 0.0 \n 2609 (2.3) \n 0.0 \n 4680 (2.3) \n 7973 (1.9) \n 2683 (0.7) \n 4199 (0.5) \n \n \n Obstructive sleep apnea2 \n 0.0 \n 4869 (4.3) \n 0.0 \n 9503 (4.6) \n 10726 (2.5) \n 5483 (1.4) \n 7027 (0.9) \n \n \n Dementia2 \n 0.0 \n 2998 (2.6) \n 0.0 \n 3838 (1.9) \n 18772 (4.4) \n 13962 (3.6) \n 36467 (4.7) \n \n \n Depression2 \n 0.0 \n 4464 (3.9) \n 0.0 \n 7701 (3.7) \n 15492 (3.7) \n 8931 (2.3) \n 17266 (2.2) \n \n \n Malignant cancer within 3 years2 \n 0.0 \n 15045 (13.2) \n 0.0 \n 25958 (12.6) \n 54617 (12.9) \n 43057 (11.1) \n 79708 (10.2) \n \n \n Muscoloskeletal/connective tissue diseases within 3 years2 \n 0.0 \n 37283 (32.6) \n 0.0 \n 66206 (32.0) \n 124052 (29.3) \n 77639 (20.0) \n 137759 (17.6) \n \n \n Alcohol abuse2 \n 0.0 \n 3654 (3.2) \n 0.0 \n 6566 (3.2) \n 10900 (2.6) \n 5618 (1.4) \n 8427 (1.1) \n \n \n Severe bleeding2 \n 0.0 \n 22922 (20.0) \n 0.0 \n 39016 (18.9) \n 72037 (17.0) \n 26950 (6.9) \n 53017 (6.8) \n \n \n Charlson Comorbidity Index2 \n 0.0 \n 3.0 [1.0, 4.0] \n 0.0 \n 3.0 [1.0, 4.0] \n 3.0 [1.0, 4.0] \n 0.0 [0.0, 2.0] \n 0.0 [0.0, 2.0] \n \n \n Charlson Comorbidity Index2 \n 0.0 \n \n 0.0 \n \n \n \n \n \n \n     0-1 \n \n 29521 (25.8) \n \n 55409 (26.8) \n 115662 (27.4) \n 276348 (71.1) \n 569447 (72.8) \n \n \n     2-3 \n \n 42102 (36.8) \n \n 77627 (37.6) \n 171369 (40.5) \n 80492 (20.7) \n 157568 (20.1) \n \n \n     4-7 \n \n 34525 (30.2) \n \n 59881 (29.0) \n 112854 (26.7) \n 26414 (6.8) \n 46081 (5.9) \n \n \n     ≥8 \n \n 8227 (7.2) \n \n 13717 (6.6) \n 22991 (5.4) \n 5584 (1.4) \n 9126 (1.2) \n \n \n Heart failure hospitalization2 \n 0.0 \n 31555 (27.6) \n 0.0 \n 77994 (37.7) \n 145770 (34.5) \n 0 (0.0) \n 0 (0.0) \n \n \n Number of heart failure hospitalizations2 \n 0.0 \n 0.0 [0.0, 1.0] \n 0.0 \n 0.0 [0.0, 1.0] \n 0.0 [0.0, 1.0] \n 0.0 [0.0, 0.0] \n 0.0 [0.0, 0.0] \n \n \n Any hospitalization2 \n 0.0 \n 79304 (69.3) \n 0.0 \n 154397 (74.7) \n 320292 (75.7) \n 199583 (51.3) \n 478972 (61.2) \n \n \n CV hospitalization2 \n 0.0 \n 52581 (46.0) \n 0.0 \n 112733 (54.6) \n 226587 (53.6) \n 67618 (17.4) \n 172962 (22.1) \n \n \n Non-CV hospitalization2 \n 0.0 \n 63308 (55.4) \n 0.0 \n 123023 (59.5) \n 261438 (61.8) \n 177818 (45.7) \n 429948 (55.0) \n \n \n Stroke/TIA hospitalization2 \n 0.0 \n 8457 (7.4) \n 0.0 \n 16164 (7.8) \n 40004 (9.5) \n 28959 (7.4) \n 78911 (10.1) \n \n \n Myocardial infarction hospitalization2 \n 0.0 \n 6029 (5.3) \n 0.0 \n 12647 (6.1) \n 34612 (8.2) \n 10723 (2.8) \n 29969 (3.8) \n \n \n Ischemic heart disease hospitalization2 \n 0.0 \n 10683 (9.3) \n 0.0 \n 24304 (11.8) \n 56005 (13.2) \n 15725 (4.0) \n 41744 (5.3) \n \n \n Ventricular fibrillation/tachycardia hospitalization2 \n 0.0 \n 1321 (1.2) \n 0.0 \n 3953 (1.9) \n 4785 (1.1) \n 223 (0.1) \n 524 (0.1) \n \n \n Pneumonia/Flue/Respiratory infection hospitalization2 \n 0.0 \n 19445 (17.0) \n 0.0 \n 39431 (19.1) \n 89403 (21.1) \n 30443 (7.8) \n 79891 (10.2) \n \n \n Pneumonia hospitalization2 \n 0.0 \n 12959 (11.3) \n 0.0 \n 26420 (12.8) \n 58778 (13.9) \n 22892 (5.9) \n 60174 (7.7) \n \n \n Renal failure hospitalization2 \n 0.0 \n 6471 (5.7) \n 0.0 \n 13711 (6.6) \n 25296 (6.0) \n 4574 (1.2) \n 10094 (1.3) \n \n \n Malignant cancer hospitalization2 \n 0.0 \n 8037 (7.0) \n 0.0 \n 14449 (7.0) \n 35025 (8.3) \n 37816 (9.7) \n 91528 (11.7) \n \n \n Severe bleeding hospitalization2 \n 0.0 \n 16292 (14.2) \n 0.0 \n 32475 (15.7) \n 64957 (15.4) \n 33183 (8.5) \n 81045 (10.4) \n \n \n Hyperkalemia hospitalization2 \n 0.0 \n 683 (0.6) \n 0.0 \n 1715 (0.8) \n 2825 (0.7) \n 235 (0.1) \n 532 (0.1) \n \n \n Hypokalemia hospitalization2 \n 0.0 \n 322 (0.3) \n 0.0 \n 816 (0.4) \n 1345 (0.3) \n 542 (0.1) \n 1195 (0.2) \n \n \n Syncope hospitalization2 \n 0.0 \n 2691 (2.4) \n 0.0 \n 6094 (2.9) \n 12114 (2.9) \n 6400 (1.6) \n 17134 (2.2) \n \n \n Trauma hospitalization2 \n 0.0 \n 14517 (12.7) \n 0.0 \n 27837 (13.5) \n 65663 (15.5) \n 44297 (11.4) \n 130595 (16.7) \n \n \n Coronary revascularization2 \n 0.0 \n 3708 (3.2) \n 0.0 \n 8998 (4.4) \n 18924 (4.5) \n 8890 (2.3) \n 17394 (2.2) \n \n \n Death2 \n 0.0 \n 64876 (56.7) \n 0.0 \n 112286 (54.3) \n 300917 (71.2) \n 127556 (32.8) \n 406620 (52.0) \n \n \n CV death2 \n 0.0 \n 38524 (33.7) \n 0.0 \n 68541 (33.2) \n 178361 (42.2) \n 40123 (10.3) \n 145478 (18.6) \n \n \n Non-CV death2 \n 0.0 \n 26352 (23.0) \n 0.0 \n 43745 (21.2) \n 122556 (29.0) \n 87433 (22.5) \n 261142 (33.4) \n \n \n Hospitalization or death Sudden cardiac death2 \n 0.0 \n 59 (0.1) \n 0.0 \n 110 (0.1) \n 346 (0.1) \n 99 (0.0) \n 542 (0.1) \n \n \n Composite CVD/HFH2 \n 0.0 \n 53843 (47.1) \n 0.0 \n 106812 (51.7) \n 247007 (58.4) \n 40123 (10.3) \n 145478 (18.6) \n \n \n Composite Death/HFH2 \n 0.0 \n 72271 (63.2) \n 0.0 \n 132076 (63.9) \n 329180 (77.8) \n 127556 (32.8) \n 406620 (52.0) \n \n\n\nNote: \n\n Patients have different follow-up times, this means that outcomes can not be interpreted directly from the table.\n\n Categorical variables are presented with n (%) and continuous variables with median [q1-q3].\n\n1 Source: SwedeHF\n\n2 Source: NPR\n\n3 Source: SCB\n\n\n\n`````\n:::\n:::\n", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": { + "include-in-header": [ + "\r\n\r\n" + ] + }, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_freeze/variabledescription/index/execute-results/html.json b/_freeze/variabledescription/index/execute-results/html.json new file mode 100644 index 0000000..e684406 --- /dev/null +++ b/_freeze/variabledescription/index/execute-results/html.json @@ -0,0 +1,14 @@ +{ + "hash": "b75e4547a913fbd84ad233eccaa860e1", + "result": { + "markdown": "---\nlayout: page\ntitle: Variable description\nexecute:\n freeze: true # never re-render during project render\nengine: knitr \nmeta_variables:\n xlsx: \"meta_variables.xlsx\"\n---\n\n```{=html}\n

\n \n  Download Variable Description\n \n

\n```", + "supporting": [], + "filters": [ + "rmarkdown/pagebreak.lua" + ], + "includes": {}, + "engineDependencies": {}, + "preserve": {}, + "postProcess": true + } +} \ No newline at end of file diff --git a/_quarto.yml b/_quarto.yml new file mode 100644 index 0000000..aec5151 --- /dev/null +++ b/_quarto.yml @@ -0,0 +1,72 @@ +# website settings +website: + title: "SHFDB4" # Your name + image: img/my_image.jpg + favicon: img/favicon.png + repo-url: https://github.com/KIHeartFailure/shfdb4/ + + # start of the navigation bar at the top of the website + navbar: + pinned: true + search: true + logo: /img/logo.jpg + + # your sub-pages + left: + - text: "Population" + href: population/index.qmd + - text: "Data Sources" + href: datasources/index.qmd + - text: "Definitions" + href: definitions/index.qmd + - text: "Versions" + href: versions/index.qmd + - text: "Variable Description" + href: variabledescription/index.qmd + - text: "Statistics" + href: statistics/index.qmd + + # your social media handles + right: + - icon: envelope + aria-label: email + href: "mailto:lina.benson@ki.se" + + +# Don't touch unless you know what you are doing :) ------------ + search: + location: navbar + type: textbox + page-footer: + left: | + Lars H Lund research group + center: | + View the code for this website on GitHub + right: | + View the R code for the database on GitHub + +project: + type: website + output-dir: docs + + preview: + port: 22222 + browser: true + watch-inputs: true + navigate: true + +execute: + freeze: true + +format: + html: + fontsize: 1.1em + theme: + - pulse + - html/styles.scss + toc: false + code-link: true + anchor-sections: true + fig-cap-location: margin + reference-location: margin + footnotes-hover: true \ No newline at end of file diff --git a/datasources/index.qmd b/datasources/index.qmd new file mode 100644 index 0000000..c2bdd8b --- /dev/null +++ b/datasources/index.qmd @@ -0,0 +1,93 @@ +--- +title: Data Sources +--- + +## The Swedish Heart Failure Registry (SwedeHF) + +The Swedish Heart Failure Registry (SwedeHF) (Swedish: RiksSvikt) is managed by Uppsala Clinical Research Center (UCR). + +SwedeHF is a health quality and research registry that started in 2000 and became nationwide 2003. In 2021 31.5% of the prevalent heart failure population in Sweden were at some point registered in SwedeHF. Coverage is lower in primary care but few patients are seen exclusively in primary care and are therefore caught and registered in cardiology or internal medicine. + +Up until April 2017 the only inclusion criterion was clinician-judged Heart Failure (HF). From April 2017 the inclusion criteria are ICD-10: I50.0, I50.1, I50.9, I42.0, I42.6, I42.7, I25.5, I11.0, I13.0, I13.2. + +The new version of SwedeHF also entailed other differences, mainly how data is collected. Previously there were no restrictions of what visits could be registered. In the new SwedeHF an index visits (the first time a patient is registered into SwedeHF) is registered and thereafter a follow-up visit within 6 months and thereafter yearly follow-ups. The yearly follow-ups can be either out-patient visits, telephone contact or survey. Only the first visit can be a hospitalization, this means that the proportion of hospitalized patients have decreased since April 2017. + +For more information, see [https://www.ucr.uu.se/rikssvikt-en/](https://www.ucr.uu.se/rikssvikt-en/) and [https://pubmed.ncbi.nlm.nih.gov/30092697/](https://pubmed.ncbi.nlm.nih.gov/30092697/). + +---- + +## Longitudinal integrated database for health insurance and labour market studies (LISA) + +The Longitudinal database on socio-economic factors (LISA) is managed by Statistics Sweden (SCB). Information on socio-economic factors (education, income, civil status) is received from LISA. + +For more information, see LISA and [https://pubmed.ncbi.nlm.nih.gov/30929112/](https://pubmed.ncbi.nlm.nih.gov/30929112/). + +---- + +## Register of the Total Population + +Register of the Total Population (Swedish: Registret över totalbefolkningen, RTB) is managed by Statistics Sweden (SCB). + +Information on number of children, country of birth and immigration/emigration is received from here. + +---- + +## The National Cancer Register + +The Swedish Cancer Register (Swedish: Cancerregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen). + +The Swedish Cancer Register was founded in 1958 and it is compulsory for every health care provider to report newly detected cancer cases to the registry. For more information, see [https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-cancer-register/](https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-cancer-register/). + +No information from the Swedish Cancer Register is included in the base version of SHFDB4 but information from the register can be added upon request. + +---- + +## The National Patient Register + +The National Patient Register (NPR) (Swedish: Patientregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen). + +From 1987 the NPR includes all in-patient care in Sweden. Since 1997 it also covers out-patient surgical procedures and from 2001 also out-patient visits in speciality (but not primary) care. Each record contains medical information on surgical procedures, hospital department and discharge diagnoses coded according to International Classification of Diseases (ICD-9 for years 1987-1996 and ICD-10 for years 1997-, except for Skåne were ICD-10 was introduced 1998). The validity of HF diagnosis in cardiology and non-cardiology clinics in Sweden is 91% and 86%, respectively ([https://pubmed.ncbi.nlm.nih.gov/15916919](https://pubmed.ncbi.nlm.nih.gov/15916919)). For more information, see [https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-patient-register/](https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-patient-register/). + +From the NPR individual comorbidities (variables beginning with sos_com_) and hospitalization outcomes (variables beginning with sos_out_hosp) were calculated as well as the Charlson Comorbidity Index. Additional comorbidities and outcomes can be made available upon request. + +---- + +## The Cause of Death Register + +The Cause of Death Register (Swedish: Dödsorsaksregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and contains data on causes of death from 1961. For more information, see [https://www.socialstyrelsen.se/statistik-och-data/register/dodsorsaksregistret/](https://www.socialstyrelsen.se/statistik-och-data/register/dodsorsaksregistret/) (information only available in Swedish). + +From the Cause of Death Register deaths (variables beginning with sos_out_death) were calculated. Additional casuses of death can be made available upon request. + +---- + +## The National Prescribed Drug Register + +The National Prescribed Drug Register (Swedish: Läkemedelsregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and from July 2005 includes all dispensed drugs. + +For more information, see [https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-prescribed-drug-register/](https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-prescribed-drug-register/). + +No information from the Prescribed Drug Register is included in the base version of SHFDB4 but information from the register can be added upon request. + +---- + +## Primary care data from Region Stockholm + +VAL/KON is managed by Region Stockholm and contains information on healthcare from providers that have an agreement with Region Stockholm. For more information, see [www.gups.sll.se/val/Valhandbok.docx](www.gups.sll.se/val/Valhandbok.docx). + +No information from VAL/KON is included in the base version of SHFDB4 but information on certain diagnosis in primary care are available and can be added upon request. + +---- + +## Swedish National Diabetes Register (NDR) + +The Swedish National Diabetes Register (NDR) is a national quality register for children and adults with diabetes. For more information, see [https://www.ndr.nu/](https://www.ndr.nu/). + +No information from NDR is included in the base version of SHFDB4 but information can be added upon request. + +---- + +## Swedish ICD & Pacemaker Registry + +The Swedish ICD & Pacemaker Registry is a national quality register. For more information, see [https://www.pacemakerregistret.se/](https://www.pacemakerregistret.se/). + +No information from ICD & Pacemaker Registry is included in the base version of SHFDB4 but information can be added upon request. \ No newline at end of file diff --git a/definitions/index.qmd b/definitions/index.qmd new file mode 100644 index 0000000..b599072 --- /dev/null +++ b/definitions/index.qmd @@ -0,0 +1,84 @@ +--- +title: Definitions +--- + +```{r setup, include=FALSE} +knitr::opts_chunk$set( + echo = FALSE, include = TRUE, comment = "", + warning = FALSE, message = FALSE +) +options(knitr.kable.NA = "") +``` + +```{r loadlibsdata} +library(tableone) +library(dplyr) +library(tidyr) +library(knitr) +library(kableExtra) + +load(file = here::here("../dm/data/rsdata_for_webb.RData")) +``` + +## Index date + + +Index date is defined as the registered date of discharge for in-patients and date of admission for out-patients in SwedeHF. For the patients identified through the National Patient Register with ICD codes the index date is defined as the first occurrence of a diagnosis of HF in main position. The controls receive the same index date as their matched case. + +---- + +## Follow-up + +The follow-up period is defined as time from index date to emigration, death or end of follow-up, 2021-12-31, whichever came first. + +For the controls the follow-up period is defined as time from the matched cases index date to heart failure diagnosis (either in NPR or SwedeHF), emigration, death or end of follow-up, 2021-12-31, whichever came first. + +---- + +## Socio-economic variables + +The socio-economic variables from LISA, Statistics Sweden, are from the year prior to the index year, so a patient with an index date 2015-03-06 will have income, marriage status and education from 2014. + +Limitations: Unmarried persons cohabiting without children are classified as Living alone. Education is not registered for individuals < 25 years. + +---- + +## Comorbidities and outcomes + +For all comorbidities and hospitalizations from the NPR date of admission/visit (INDATUM) is used to calculate if it is a comorbidity or outcome. Adjoining hospitalizations, where the discharge date of the former hospitalization is the same as the admission date of the latter, are merged together into one hospitalization in order to take into account possible transferrals between wards/hospitals. + +Limitation: For the comorbidities MI, IHD, Stroke, CABG and PCI there is no time restriction applied. There is no data prior to 1987 (for PCI, CABG only from 1997) and the earlier registrations will therefore not have had the possibility to accumulate comorbidities to the same extent as the latter. For more details see [Data Sources](https://kiheartfailure.github.io/shfdb4/datasources/))). + +Limitation: Out-patient visits in speciality (but not primary) care are covered from 2001. Therefore, for the earlier visits, these are (partially) not included in the comorbidities. + +```{r comhospdeath} +comoutmeta <- rbind(outcommeta, deathmeta) +comoutmeta <- comoutmeta %>% + mutate(Code = gsub(",", ", ", Code), + Position = gsub("DIA_all", "All DIA", Position), + Position = gsub("OP_all", "All OP", Position), + Position = gsub("ekod_all", "All Ekod", Position), + Position = gsub("sos_deathcause", "ULORSAK", Position), + Period = gsub("0--1826.25", "-5yrs-0", Period), + Period = gsub("0--1095.75", "-3yrs-0", Period), + Period = gsub("0-", "-0", Period), + Register = ifelse(stringr::str_detect(Variable, "sos_out_hosp|sos_out_counthosp"), "NPR (in)", Register) + ) + +kable(comoutmeta) +``` + +---- + +## Charlson comorbidity index + +The ICD-9/10 codes used are not necessarily the same as in the other comorbidities and outcomes but +from https://www.dovepress.com/articles.php?article_id=61144. + +```{r cci} +ccimeta <- ccimeta %>% + mutate(Code = gsub(",", ", ", Code), + Position = gsub("DIA_all", "All DIA", Position), + Period = gsub("0--3652.5", "-10yrs-0", Period)) +kable(ccimeta) +``` diff --git a/docs/.nojekyll b/docs/.nojekyll new file mode 100644 index 0000000..e69de29 diff --git a/docs/404.html b/docs/404.html new file mode 100644 index 0000000..99aa586 --- /dev/null +++ b/docs/404.html @@ -0,0 +1,398 @@ + + + + + + + + + +SHFDB4 - 404 + + + + + + + + + + + + + + + + + + + + + + + + + + +
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Data Sources

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The Swedish Heart Failure Registry (SwedeHF)

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The Swedish Heart Failure Registry (SwedeHF) (Swedish: RiksSvikt) is managed by Uppsala Clinical Research Center (UCR).

+

SwedeHF is a health quality and research registry that started in 2000 and became nationwide 2003. In 2021 31.5% of the prevalent heart failure population in Sweden were at some point registered in SwedeHF. Coverage is lower in primary care but few patients are seen exclusively in primary care and are therefore caught and registered in cardiology or internal medicine.

+

Up until April 2017 the only inclusion criterion was clinician-judged Heart Failure (HF). From April 2017 the inclusion criteria are ICD-10: I50.0, I50.1, I50.9, I42.0, I42.6, I42.7, I25.5, I11.0, I13.0, I13.2.

+

The new version of SwedeHF also entailed other differences, mainly how data is collected. Previously there were no restrictions of what visits could be registered. In the new SwedeHF an index visits (the first time a patient is registered into SwedeHF) is registered and thereafter a follow-up visit within 6 months and thereafter yearly follow-ups. The yearly follow-ups can be either out-patient visits, telephone contact or survey. Only the first visit can be a hospitalization, this means that the proportion of hospitalized patients have decreased since April 2017.

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For more information, see https://www.ucr.uu.se/rikssvikt-en/ and https://pubmed.ncbi.nlm.nih.gov/30092697/.

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Longitudinal integrated database for health insurance and labour market studies (LISA)

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The Longitudinal database on socio-economic factors (LISA) is managed by Statistics Sweden (SCB). Information on socio-economic factors (education, income, civil status) is received from LISA.

+

For more information, see LISA and https://pubmed.ncbi.nlm.nih.gov/30929112/.

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Register of the Total Population

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Register of the Total Population (Swedish: Registret över totalbefolkningen, RTB) is managed by Statistics Sweden (SCB).

+

Information on number of children, country of birth and immigration/emigration is received from here.

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The National Cancer Register

+

The Swedish Cancer Register (Swedish: Cancerregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen).

+

The Swedish Cancer Register was founded in 1958 and it is compulsory for every health care provider to report newly detected cancer cases to the registry. For more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-cancer-register/.

+

No information from the Swedish Cancer Register is included in the base version of SHFDB4 but information from the register can be added upon request.

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The National Patient Register

+

The National Patient Register (NPR) (Swedish: Patientregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen).

+

From 1987 the NPR includes all in-patient care in Sweden. Since 1997 it also covers out-patient surgical procedures and from 2001 also out-patient visits in speciality (but not primary) care. Each record contains medical information on surgical procedures, hospital department and discharge diagnoses coded according to International Classification of Diseases (ICD-9 for years 1987-1996 and ICD-10 for years 1997-, except for Skåne were ICD-10 was introduced 1998). The validity of HF diagnosis in cardiology and non-cardiology clinics in Sweden is 91% and 86%, respectively (https://pubmed.ncbi.nlm.nih.gov/15916919). For more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-patient-register/.

+

From the NPR individual comorbidities (variables beginning with sos_com_) and hospitalization outcomes (variables beginning with sos_out_hosp) were calculated as well as the Charlson Comorbidity Index. Additional comorbidities and outcomes can be made available upon request.

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The Cause of Death Register

+

The Cause of Death Register (Swedish: Dödsorsaksregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and contains data on causes of death from 1961. For more information, see https://www.socialstyrelsen.se/statistik-och-data/register/dodsorsaksregistret/ (information only available in Swedish).

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From the Cause of Death Register deaths (variables beginning with sos_out_death) were calculated. Additional casuses of death can be made available upon request.

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The National Prescribed Drug Register

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The National Prescribed Drug Register (Swedish: Läkemedelsregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and from July 2005 includes all dispensed drugs.

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For more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-prescribed-drug-register/.

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No information from the Prescribed Drug Register is included in the base version of SHFDB4 but information from the register can be added upon request.

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Primary care data from Region Stockholm

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VAL/KON is managed by Region Stockholm and contains information on healthcare from providers that have an agreement with Region Stockholm. For more information, see www.gups.sll.se/val/Valhandbok.docx.

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No information from VAL/KON is included in the base version of SHFDB4 but information on certain diagnosis in primary care are available and can be added upon request.

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Swedish National Diabetes Register (NDR)

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The Swedish National Diabetes Register (NDR) is a national quality register for children and adults with diabetes. For more information, see https://www.ndr.nu/.

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No information from NDR is included in the base version of SHFDB4 but information can be added upon request.

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Swedish ICD & Pacemaker Registry

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The Swedish ICD & Pacemaker Registry is a national quality register. For more information, see https://www.pacemakerregistret.se/.

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No information from ICD & Pacemaker Registry is included in the base version of SHFDB4 but information can be added upon request.

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+ + + + + \ No newline at end of file diff --git a/docs/definitions/index.html b/docs/definitions/index.html new file mode 100644 index 0000000..1aa5db1 --- /dev/null +++ b/docs/definitions/index.html @@ -0,0 +1,942 @@ + + + + + + + + + +SHFDB4 - Definitions + + + + + + + + + + + + + + + + + + + + + + + + + + +
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Definitions

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Index date

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Index date is defined as the registered date of discharge for in-patients and date of admission for out-patients in SwedeHF. For the patients identified through the National Patient Register with ICD codes the index date is defined as the first occurrence of a diagnosis of HF in main position. The controls receive the same index date as their matched case.

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Follow-up

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The follow-up period is defined as time from index date to emigration, death or end of follow-up, 2021-12-31, whichever came first.

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For the controls the follow-up period is defined as time from the matched cases index date to heart failure diagnosis (either in NPR or SwedeHF), emigration, death or end of follow-up, 2021-12-31, whichever came first.

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Socio-economic variables

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The socio-economic variables from LISA, Statistics Sweden, are from the year prior to the index year, so a patient with an index date 2015-03-06 will have income, marriage status and education from 2014.

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Limitations: Unmarried persons cohabiting without children are classified as Living alone. Education is not registered for individuals < 25 years.

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+

Comorbidities and outcomes

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For all comorbidities and hospitalizations from the NPR date of admission/visit (INDATUM) is used to calculate if it is a comorbidity or outcome. Adjoining hospitalizations, where the discharge date of the former hospitalization is the same as the admission date of the latter, are merged together into one hospitalization in order to take into account possible transferrals between wards/hospitals.

+

Limitation: For the comorbidities MI, IHD, Stroke, CABG and PCI there is no time restriction applied. There is no data prior to 1987 (for PCI, CABG only from 1997) and the earlier registrations will therefore not have had the possibility to accumulate comorbidities to the same extent as the latter. For more details see Data Sources)).

+

Limitation: Out-patient visits in speciality (but not primary) care are covered from 2001. Therefore, for the earlier visits, these are (partially) not included in the comorbidities.

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VariableCodeRegisterPositionPeriod
sos_com_hypertensionICD:I10-5NPR (in+out)All DIA-5yrs-0
sos_com_diabetesICD:E10-4NPR (in+out)All DIA-5yrs-0
sos_com_ihdICD:410-4, I20-5NPR (in+out)All DIA-0
sos_com_miICD:410, 412, I21, I22, I252NPR (in+out)All DIA-0
sos_com_anginaICD:I20NPR (in+out)All DIA-5yrs-0
sos_com_pciOP:FNGNPR (in+out)All OP-0
sos_com_cabgICD:Z951, Z955 OP:FNA, FNB, FNC, FND, FNE, FNF, FNHNPR (in+out)All DIA All OP-0
sos_com_dcmICD:I420NPR (in+out)All DIA-5yrs-0
sos_com_padICD:I70-3NPR (in+out)All DIA-5yrs-0
sos_com_afICD:I48NPR (in+out)All DIA-5yrs-0
sos_com_strokeICD:430-4, 438, I60-4, I690-4NPR (in+out)All DIA-0
sos_com_tiaICD:G45NPR (in+out)All DIA-5yrs-0
sos_com_valvularICD:I05-8, I34-9, Q22, Q230-3, Q230-3, Q235-9, Z952-4NPR (in+out)All DIA-5yrs-0
sos_com_renalICD:N17-9, Z491, Z492 OP:KAS00, KAS10, KAS20, DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35NPR (in+out)All DIA All OP-5yrs-0
sos_com_hyperkalemiaICD:E875NPR (in+out)All DIA-5yrs-0
sos_com_hypokalemiaICD:E876NPR (in+out)All DIA-5yrs-0
sos_com_dialysisICD:Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35NPR (in+out)All DIA All OP-5yrs-0
sos_com_copdICD:J40-4NPR (in+out)All DIA-5yrs-0
sos_com_respiratoryICD:JNPR (in+out)All DIA-5yrs-0
sos_com_liverICD:B18, I85, I864, I982, K70, K710, K711, K713-7, K72-4, K760, K762-9NPR (in+out)All DIA-5yrs-0
sos_com_sleepapneaICD:G473NPR (in+out)All DIA-5yrs-0
sos_com_dementiaICD:F00-4, R54NPR (in+out)All DIA-5yrs-0
sos_com_depressionICD:F32-4NPR (in+out)All DIA-5yrs-0
sos_com_cancer3yICD:CNPR (in+out)HDIA-3yrs-0
sos_com_muscoloskeletal3yICD:MNPR (in+out)All DIA-3yrs-0
sos_com_alcoholICD:E244, E52, F10, G312, G621, G721, I426, K292, K70, K860, O354, P043, Q860, T51, Z502, Z714 Ekod:Y90, Y91NPR (in+out)All DIA All Ekod-5yrs-0
sos_com_bleedICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029NPR (in+out)All DIA All OP-5yrs-0
sos_out_hosphfICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428NPR (in)HDIA1-
sos_out_counthosphfICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428NPR (in)HDIA1-
sos_out_hospanyICD:NPR (in)HDIA1-
sos_out_hospcvICD:I, J81, K761, G45, R570NPR (in)HDIA1-
sos_out_hospnoncvICD:Not I, J81, K761, G45, R570NPR (in)HDIA1-
sos_out_hospstroketiaICD:I60-4, G45NPR (in)HDIA1-
sos_out_hospmiICD:I21, I22NPR (in)HDIA1-
sos_out_hospihdICD:I20-5NPR (in)HDIA1-
sos_out_hospventfibICD:I490, I472NPR (in)HDIA1-
sos_out_hospscdICD:I461NPR (in)HDIA1-
sos_out_hosprespiratoryICD:JNPR (in)HDIA1-
sos_out_hosppneumoniaICD:J09, J10-8NPR (in)HDIA1-
sos_out_hosprenalICD:N17-9, KAS00, KAS10, KAS20, Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35NPR (in)HDIA All OP1-
sos_out_hospcancerICD:CNPR (in)HDIA1-
sos_out_hospbleedICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029NPR (in)HDIA All OP1-
sos_out_hosphyperkalemiaICD:E875NPR (in)HDIA1-
sos_out_hosphypokalemiaICD:E876NPR (in)HDIA1-
sos_out_hospsyncopeICD:R55NPR (in)HDIA1-
sos_out_hosptraumaICD:S, T0, T10-4NPR (in)HDIA1-
sos_out_hosprevascOP:FNG, FNA, FNB, FNC, FND, FNE, FNF, FNHNPR (in)All OP1-
sos_out_deathcvICD:I, J81, K761, R570, G45Cause of DeathULORSAK
sos_out_deathscdICD:I461Cause of DeathULORSAK
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Charlson comorbidity index

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The ICD-9/10 codes used are not necessarily the same as in the other comorbidities and outcomes but from https://www.dovepress.com/articles.php?article_id=61144.

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VariableCodeRegisterPositionPeriod
sos_com_cci_miICD:410, 412, I21, I22, I252NPR (in+out)All DIA-10yrs-0
sos_com_cci_chfICD:402A, 402B, 402X, 404A, 404B, 404X, 425E, 425F, 425H, 425W, 425X, 428, I110, I130, I132, I255, I420, I426-9, I43, I50NPR (in+out)All DIA-10yrs-0
sos_com_cci_pvdICD:440, 441, 443B, 443X, 447B, 557, I70, I71, I731, I738, I739, I771, I790, I792, K55NPR (in+out)All DIA-10yrs-0
sos_com_cci_cdICD:430-8, G45, I60-4, I67, I69NPR (in+out)All DIA-10yrs-0
sos_com_cci_copdICD:491, 492, 496, J43-4NPR (in+out)All DIA-10yrs-0
sos_com_cci_copdotherICD:490, 493-5, 500-8, 516, 517, J41, J42, J45-7, J60-9, J70NPR (in+out)All DIA-10yrs-0
sos_com_cci_rheumaticICD:446, 696A, 710A-E, 714, 719D, 720, 725, M05, M06, M123, M070-3, M08, M13, M30, M313-6, M32, M33, M34, M350, M351, M353, M45, M46NPR (in+out)All DIA-10yrs-0
sos_com_cci_dementiaICD:290, 294B, 331A-C, 331X, F00-3, F051, G30, G311, G319NPR (in+out)All DIA-10yrs-0
sos_com_cci_plegiaICD:342, 343, 344A-F, G114, G80-2, G830-3, G838NPR (in+out)All DIA-10yrs-0
sos_com_cci_diabetesICD:250A-C, E100, E101, E110, E111, E120, E121, E130, E131, E140, E141NPR (in+out)All DIA-10yrs-0
sos_com_cci_diabetescompliationICD:250D-G, E102-5, E107, E112-7, E122-7, E132-7, E142-7NPR (in+out)All DIA-10yrs-0
sos_com_cci_renalICD:403A, 403B, 403X, 582, 583, 585, 586, 588A, V42A, V45B, V56, N032-7, N052-7, N11, N18, N19, N250, I120, I131, Q611-4, Z49, Z940, Z992NPR (in+out)All DIA-10yrs-0
sos_com_cci_livermildICD:070, 571C, 571E, 571F, 573, B15-9, K703, K73, K746, K703, K754NPR (in+out)All DIA-10yrs-0
sos_com_cci_liverspecICD:789F, R18NPR (in+out)All DIA-10yrs-0
sos_com_cci_livermodsevICD:789F, 456A-C, 572D-E, 572C, R18, I850, I859, I982, I983NPR (in+out)All DIA-10yrs-0
sos_com_cci_pudICD:531-4, K25-8NPR (in+out)All DIA-10yrs-0
sos_com_cci_malignancyICD:14-9, 200-8, C0-7, C80-6, C88-9, C90-7NPR (in+out)All DIA-10yrs-0
sos_com_cci_metastatictumorICD:196-8, 199A, 199B, C77-9, C80NPR (in+out)All DIA-10yrs-0
sos_com_cci_hivICD:079J, 279K, B20-4, F024, O987, R75, Z114, Z219, Z711NPR (in+out)All DIA-10yrs-0
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SwedeHF database 4 (SHFDB4)

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A Heart Failure cohort from Sweden 2000 - 2021. The population consists of

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  1. patients recorded in the Swedish Heart Failure Registry (SwedeHF),

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  2. patients recorded in the National Patient Register with a ICD-10 code in main position for HF and

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  3. gender, year of birth and county of residence matched HF-free controls.

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Please feel free to contact me if you have any questions.

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+View/download the R code for the database +
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Population

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Patients registered in SwedeHF

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All patients recorded in SwedeHF are included.

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Patients with HF from the National Patient Register

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Patients with an ICD-10 code for HF in main position in the National Patient Register (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761) starting from 2000-01-01 with no previous ICD-9/10 code for HF (I110 I130 I132 I255 I420 I423 1425 I426 I427 I428 I429 I43 I50 J81 K761 ICD-9: 414W 425E 425F 425G 425H 425W 425X 428) since 1987.

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HF-free controls

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For each post in SwedeHF or the first date in the National Patient Register a set of controls was chosen by Statistics Sweden in a ratio of 2:1. Since a person can have more than one registered post in SwedeHF a patient can have more than 2 controls in total, up to 2 for each posts.

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Eligible controls were persons without re-used Swedish personal identity numbers (PINs) and free of HF, defined either in the National Patient registry (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761, R570, ICD-9: 414W, 425E-H, 425W, 425X, 428) or SwedeHF, at the end of the year of the index date for the case and matched by gender, year of birth and county of residence at index. For posts with age ≥ 90 years, controls were only matched by gender and year of birth due to the smaller available number of controls.

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The selection of controls was performed without replacement.

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A control was allowed to become a case after the year of the index date for the case.

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A full set of controls (n = 2) was not found for all cases:

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PopulationNo controlsPostsUnique patients
Case SwedeHF038492156
Case SwedeHF1172107319
Case SwedeHF2185575104900
Case NPR01905719057
Case NPR12643326433
Case NPR2377386377386
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Inclusion/exclusion criteria

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CriteriaCase SwedeHFCase NPRControl SwedeHFControl NPR
No of posts recieved216652471853405913802436
Exclude posts with duplicated index dates216029
Exclude posts with with index date < 2000-01-01216026437182405907799666
Exclude posts with with index date > 2021-12-31207290426074388928785550
Exclude posts < 18 years207277424752388903782942
Exclude posts that are not present in SCB register206875423401388903782942
Exclude posts with reused PINs206640423026388903782942
Exclude posts censored end fu < index206634422876388838782222
Exclude controls without cases206634422876388838782222
Exclude posts with end of follow-up <= index date (died in hospital)203425
Unique patients112423
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+ + + + + \ No newline at end of file diff --git a/docs/search.json b/docs/search.json new file mode 100644 index 0000000..fa89d23 --- /dev/null +++ b/docs/search.json @@ -0,0 +1,212 @@ +[ + { + "objectID": "versions/index.html", + "href": "versions/index.html", + "title": "Versions", + "section": "", + "text": "This is the first version. Consists only of SwedeHF." + }, + { + "objectID": "versions/index.html#section", + "href": "versions/index.html#section", + "title": "Versions", + "section": "", + "text": "This is the first version. Consists only of SwedeHF." + }, + { + "objectID": "versions/index.html#section-1", + "href": "versions/index.html#section-1", + "title": "Versions", + "section": "4.0.1", + "text": "4.0.1\n\nChanged name from kidney to renal (sos_com_kidney, sos_out_hospkidney, sos_outtime_hospkidney).\nChanged ICD codes for HF (R57 to R570), affects variables sos_out_counthosphf, sos_outtime_hospcv, sos_out_hospcv, sos_outtime_hosphf, sos_out_hosphf, sos_out_deathcv, sos_out_deathnoncv, sos_out_deathcvhosphf, sos_out_deathhosphf, sos_timeprevhosphf, sos_durationhf, sos_out_hospnoncv, sos_outtime_hospnoncv, sos_location (all minor changes n < 100).\nChanged ICD codes for sos_com_dementia (added R54) (minor change n = 35).\nChanged ICD codes for sos_com_valvular (added Q230-3, Q235-9) (minor change n = 11).\nChanged ICD codes for sos_out_hosprespiratory (added so all J) (major change n = 11282).\nAdded sos_com_respiratory." + }, + { + "objectID": "versions/index.html#section-2", + "href": "versions/index.html#section-2", + "title": "Versions", + "section": "4.1.0", + "text": "4.1.0\n\nAdded HF population from NPR and HF-free controls.\nAdded categorical variable for Charlson Comorbidity Index and QoL.\nAdded shf_sos_prevhfh1yr.\nChanged so levels of shf_potassium_cat starts with capital letter." + }, + { + "objectID": "versions/index.html#section-3", + "href": "versions/index.html#section-3", + "title": "Versions", + "section": "4.1.1", + "text": "4.1.1\n\nshf_age_cat 3 levels (previously 2)\nRemoved shf_eforg, shf_bmiimp, shf_bmiimp_cat\nAdded shf_fatigue, shf_outofbreath, shf_mobility, shf_hygiene, shf_activities, shf_pain, shf_anxiety\nExcluded 3 patients with fu time = 0\nAdded data on discharge and admission labs in rsdatafull\nshf_durationhf changed names of levels\n1-4 values changed in shf_durationhf, shf_primaryetiology, shf_diabetes, shf_sos_com_diabetes, shf_diabetestype, shf_af, shf_valvedisease, shf_lungdisease, shf_dcm due to different order of selection\nApprox 100 changes in shf_height, shf_bmi, shf_bmi_cat due to imputation of bmi prior to cleaning outliers\nsos_deathcause set to missing for patients with sos_out_death = No (patients who died > 2021-12-31)\nChanges in number of patients for NPR HF, controls (NPR pop and SwedeHF) in rsdatafull due to SweeHF controls now also for patients died in-hospital, and linked hospitalizations used for defining the population and controls." + }, + { + "objectID": "statistics/index.html", + "href": "statistics/index.html", + "title": "Statistics", + "section": "", + "text": "Descriptive statistics over time can be found: https://swedehf.shinyapps.io/deskstatshfdb4" + }, + { + "objectID": "statistics/index.html#over-time---interactive", + "href": "statistics/index.html#over-time---interactive", + "title": "Statistics", + "section": "", + "text": "Descriptive statistics over time can be found: https://swedehf.shinyapps.io/deskstatshfdb4" + }, + { + "objectID": "statistics/index.html#descriptive-statistics", + "href": "statistics/index.html#descriptive-statistics", + "title": "Statistics", + "section": "Descriptive statistics", + "text": "Descriptive statistics\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nPatients (last post)\n\n\nPosts\n\n\n\n\n\n\nVariable\n% missing\nSwedeHF\n% missing\nSwedeHF\nCase NPR\nControl SwedeHF\nControl NPR\n\n\n\n\nn\n\n114375\n\n206634\n422876\n388838\n782222\n\n\nncontrols\n0.0\n2.0 [2.0, 2.0]\n0.0\n2.0 [2.0, 2.0]\n2.0 [2.0, 2.0]\n0.0 [0.0, 0.0]\n0.0 [0.0, 0.0]\n\n\nTime in hospital at index hospitalization (days)1\n60.9\n5.0 [3.0, 9.0]\n63.8\n5.0 [3.0, 9.0]\n\n\n\n\n\nIndex year1\n0.0\n2015.0 [2010.0, 2019.0]\n0.0\n2014.0 [2010.0, 2018.0]\n2011.0 [2005.0, 2016.0]\n2014.0 [2010.0, 2018.0]\n2010.0 [2005.0, 2016.0]\n\n\nType of visit Index1\n0.0\n68651 (60.0)\n0.0\n115634 (56.0)\n\n\n\n\n\nLVEF (%)1\n85.6\n40.0 [30.0, 50.0]\n86.5\n39.0 [30.0, 45.0]\n\n\n\n\n\nLVEF (%)1\n19.9\n\n17.1\n\n\n\n\n\n\n    ≥50\n\n23497 (25.7)\n\n38003 (22.2)\n\n\n\n\n\n    40-49\n\n22033 (24.1)\n\n39894 (23.3)\n\n\n\n\n\n    30-39\n\n23867 (26.1)\n\n46520 (27.2)\n\n\n\n\n\n    <30\n\n22177 (24.2)\n\n46790 (27.3)\n\n\n\n\n\nLVEF (%)1\n19.9\n\n17.1\n\n\n\n\n\n\n    HFrEF\n\n46044 (50.3)\n\n93310 (54.5)\n\n\n\n\n\n    HFmrEF\n\n22033 (24.1)\n\n39894 (23.3)\n\n\n\n\n\n    HFpEF\n\n23497 (25.7)\n\n38003 (22.2)\n\n\n\n\n\nSex Male1\n0.0\n70503 (61.6)\n0.0\n132380 (64.1)\n226402 (53.5)\n244109 (62.8)\n408993 (52.3)\n\n\nAge (years)1\n0.0\n77.0 [69.0, 84.0]\n0.0\n76.0 [67.0, 83.0]\n80.0 [71.0, 86.0]\n75.0 [67.0, 82.0]\n79.0 [70.0, 85.0]\n\n\nCivil status Single1\n27.9\n36905 (44.8)\n27.5\n63189 (42.2)\n\n\n\n\n\nLiving conditions Own home1\n44.5\n59898 (94.4)\n44.4\n110190 (95.8)\n\n\n\n\n\nLocation In-patient1\n0.0\n44750 (39.1)\n0.0\n74851 (36.2)\n\n\n\n\n\nSmoking1\n26.9\n\n23.3\n\n\n\n\n\n\n    Current\n\n9116 (10.9)\n\n17267 (10.9)\n\n\n\n\n\n    Former\n\n36685 (43.9)\n\n70920 (44.8)\n\n\n\n\n\n    Never\n\n37769 (45.2)\n\n70225 (44.3)\n\n\n\n\n\nSmoking1\n26.9\n9116 (10.9)\n23.3\n17267 (10.9)\n\n\n\n\n\nAlcohol Risk1\n42.5\n2836 (4.3)\n38.9\n5179 (4.1)\n\n\n\n\n\nDuration of HF ≥6mo1\n2.8\n68600 (61.7)\n2.5\n124933 (62.0)\n\n\n\n\n\nPrimary etiology1\n40.9\n\n40.3\n\n\n\n\n\n\n    DCM\n\n4597 (6.8)\n\n10169 (8.2)\n\n\n\n\n\n    Heart valve disease\n\n5387 (8.0)\n\n9187 (7.4)\n\n\n\n\n\n    Hypertension\n\n17917 (26.5)\n\n31520 (25.5)\n\n\n\n\n\n    IHD\n\n26407 (39.1)\n\n50168 (40.6)\n\n\n\n\n\n    Known alcoholic cardiomyopathy\n\n467 (0.7)\n\n898 (0.7)\n\n\n\n\n\n    Other\n\n12828 (19.0)\n\n21510 (17.4)\n\n\n\n\n\nNYHA class1\n30.0\n\n26.1\n\n\n\n\n\n\n    I\n\n10233 (12.8)\n\n17921 (11.7)\n\n\n\n\n\n    II\n\n37273 (46.5)\n\n73193 (48.0)\n\n\n\n\n\n    III\n\n29222 (36.5)\n\n56325 (36.9)\n\n\n\n\n\n    IV\n\n3390 (4.2)\n\n5173 (3.4)\n\n\n\n\n\nNYHA class III-IV1\n30.0\n32612 (40.7)\n26.1\n61498 (40.3)\n\n\n\n\n\nKillip class1\n94.4\n\n95.8\n\n\n\n\n\n\n    Chock or hypertension\n\n17 (0.3)\n\n27 (0.3)\n\n\n\n\n\n    Edema\n\n160 (2.5)\n\n217 (2.5)\n\n\n\n\n\n    No signs of HF\n\n2904 (45.4)\n\n4128 (47.3)\n\n\n\n\n\n    Rales or crackles\n\n3310 (51.8)\n\n4349 (49.9)\n\n\n\n\n\nWeight (kg)1\n12.9\n77.4 [66.0, 90.0]\n11.8\n79.0 [67.8, 91.5]\n\n\n\n\n\nWeight at admission/visit (kg)1\n32.7\n78.0 [66.4, 90.4]\n37.2\n79.0 [68.0, 91.8]\n\n\n\n\n\nWeight at discharge   (hospitalized patients) (kg)1\n94.8\n75.5 [63.5, 88.7]\n96.1\n77.0 [65.0, 90.0]\n\n\n\n\n\nHeight (cm)1\n32.0\n172.0 [164.0, 179.0]\n26.0\n172.0 [165.0, 179.0]\n\n\n\n\n\nSystolic blood pressure (mmHg)1\n3.9\n125.0 [110.0, 140.0]\n3.3\n125.0 [110.0, 140.0]\n\n\n\n\n\nSystolic blood pressure at admission/visit (mmHg)1\n25.0\n126.0 [112.0, 140.0]\n30.4\n125.0 [112.0, 140.0]\n\n\n\n\n\nSystolic blood pressure at discharge   (hospitalized patients) (mmHg)1\n94.0\n125.0 [111.0, 140.0]\n95.5\n125.0 [110.0, 140.0]\n\n\n\n\n\nDiastolic blood pressure (mmHg)1\n3.8\n70.0 [65.0, 80.0]\n3.2\n70.0 [65.0, 80.0]\n\n\n\n\n\nDiastolic blood pressure at admission/visit (mmHg)1\n25.0\n72.0 [65.0, 80.0]\n30.3\n72.0 [65.0, 80.0]\n\n\n\n\n\nDiastolic blood pressure at discharge   (hospitalized patients) (mmHg)1\n93.9\n72.0 [65.0, 80.0]\n95.5\n72.0 [65.0, 80.0]\n\n\n\n\n\nMean arterial pressure1\n3.8\n90.0 [81.7, 99.7]\n3.2\n90.0 [81.7, 99.0]\n\n\n\n\n\nMean arterial pressure >901\n3.8\n52421 (47.6)\n3.2\n94489 (47.2)\n\n\n\n\n\nHeart rate (beats/min)1\n6.5\n71.0 [63.0, 82.0]\n5.7\n71.0 [63.0, 81.0]\n\n\n\n\n\nHeart rate at admission/visit (beats/min)1\n27.0\n72.0 [63.0, 83.0]\n32.1\n71.0 [63.0, 82.0]\n\n\n\n\n\nHeart rate at discharge   (hospitalized patients) (beats/min)1\n94.2\n74.0 [65.0, 85.0]\n95.6\n74.0 [65.0, 85.0]\n\n\n\n\n\nHeart rate (beats/min) >701\n6.5\n55096 (51.5)\n5.7\n98701 (50.7)\n\n\n\n\n\nHemoglobin (g/L)1\n8.2\n131.0 [118.0, 143.0]\n8.1\n132.0 [120.0, 144.0]\n\n\n\n\n\nHemoglobin at admission/visit (g/L)1\n29.2\n132.0 [119.0, 144.0]\n34.7\n133.0 [120.0, 145.0]\n\n\n\n\n\nHemoglobin at discharge   (hospitalized patients) (g/L)1\n96.3\n119.0 [106.0, 135.0]\n97.2\n122.0 [107.0, 137.0]\n\n\n\n\n\nAnemia1\n8.2\n39397 (37.5)\n8.1\n66947 (35.2)\n\n\n\n\n\nPotassium (mmol/L)1\n19.9\n4.2 [3.9, 4.5]\n18.7\n4.2 [3.9, 4.5]\n\n\n\n\n\nPotassium at admission/visit (mmol/L)1\n36.0\n4.2 [3.9, 4.5]\n39.9\n4.2 [3.9, 4.5]\n\n\n\n\n\nPotassium at discharge   (hospitalized patients) (mmol/L)1\n94.8\n4.0 [3.7, 4.3]\n96.1\n4.0 [3.7, 4.3]\n\n\n\n\n\nPotassium (mmol/L)1\n19.9\n\n18.7\n\n\n\n\n\n\n    Normakalemia\n\n83777 (91.5)\n\n155018 (92.3)\n\n\n\n\n\n    Hypokalemia\n\n4060 (4.4)\n\n6444 (3.8)\n\n\n\n\n\n    Hyperkalemia\n\n3725 (4.1)\n\n6446 (3.8)\n\n\n\n\n\nSodium (mmol/l)1\n35.0\n140.0 [138.0, 142.0]\n35.1\n140.0 [138.0, 142.0]\n\n\n\n\n\nSodium at admission/visit (mmol/l)1\n46.8\n140.0 [138.0, 142.0]\n50.5\n140.0 [138.0, 142.0]\n\n\n\n\n\nSodium at discharge   (hospitalized patients) (mmol/l)1\n95.0\n140.0 [138.0, 142.0]\n96.2\n140.0 [138.0, 142.0]\n\n\n\n\n\nCreatinine (µmol/L)1\n3.2\n97.0 [79.0, 126.0]\n2.9\n97.0 [79.0, 124.0]\n\n\n\n\n\nCreatinine at admission/visit (µmol/L)1\n24.6\n95.0 [78.0, 122.0]\n30.2\n94.0 [77.0, 119.0]\n\n\n\n\n\nCreatinine at discharge   (hospitalized patients) (µmol/L)1\n94.8\n100.0 [78.0, 133.0]\n96.1\n97.0 [78.0, 128.0]\n\n\n\n\n\neGFR (mL/min/1.73 m²)1\n2.9\n62.7 [44.8, 82.7]\n2.7\n64.0 [46.4, 83.4]\n\n\n\n\n\neGFR (mL/min/1.73 m²) <601\n2.9\n51262 (46.2)\n2.7\n88931 (44.2)\n\n\n\n\n\nNT-proBNP (pg/ml)1\n44.7\n2066.0 [812.0, 4950.0]\n44.1\n2000.0 [810.0, 4563.0]\n\n\n\n\n\nNT-proBNP at admission/visit (pg/ml)1\n55.0\n1971.0 [770.0, 4633.0]\n57.6\n1900.0 [765.0, 4296.0]\n\n\n\n\n\nNT-proBNP at discharge   (hospitalized patients) (pg/ml)1\n97.9\n3660.0 [1657.0, 8656.5]\n98.4\n3380.0 [1574.0, 7652.5]\n\n\n\n\n\nBNP (pg/ml)1\n95.6\n580.0 [219.0, 1335.5]\n95.1\n527.0 [202.0, 1230.0]\n\n\n\n\n\nTransferrin (%)1\n89.7\n24.0 [17.0, 32.0]\n90.5\n24.0 [17.0, 33.0]\n\n\n\n\n\nFerritin (µg/l)1\n87.9\n142.0 [71.0, 264.0]\n88.8\n142.0 [71.0, 262.0]\n\n\n\n\n\nQRS width (ms)1\n22.3\n104.0 [90.0, 132.0]\n22.2\n106.0 [92.0, 136.0]\n\n\n\n\n\nLeft Bundle Branch Block (LBBB)1\n21.7\n15800 (17.6)\n21.7\n30529 (18.9)\n\n\n\n\n\nLoop diuretic IV1\n81.3\n5479 (25.5)\n82.3\n7554 (20.6)\n\n\n\n\n\nFerric carboxymaltose IV1\n57.2\n2501 (5.1)\n59.6\n3917 (4.7)\n\n\n\n\n\nFerric carboxymaltose IV dose (mg)1\n97.9\n1000.0 [1000.0, 1000.0]\n98.2\n1000.0 [1000.0, 1000.0]\n\n\n\n\n\nUnplanned inotrope support1\n39.4\n1356 (2.0)\n40.0\n3640 (2.9)\n\n\n\n\n\nDiuretic1\n0.6\n86951 (76.5)\n0.5\n158572 (77.1)\n\n\n\n\n\nLoop diuretic1\n27.4\n60440 (72.8)\n27.8\n108999 (73.1)\n\n\n\n\n\nLoop diuretic substance1\n72.9\n\n75.5\n\n\n\n\n\n\n    Bumetanid\n\n230 (0.7)\n\n339 (0.7)\n\n\n\n\n\n    Furosemid\n\n30618 (98.8)\n\n50174 (98.9)\n\n\n\n\n\n    Toresamid\n\n127 (0.4)\n\n203 (0.4)\n\n\n\n\n\nLoop diuretic dose (mg/24h)1\n54.9\n40.0 [40.0, 80.0]\n54.6\n40.0 [40.0, 80.0]\n\n\n\n\n\nLoop diuretic usage When necessary1\n47.3\n11615 (19.3)\n47.4\n20892 (19.2)\n\n\n\n\n\nACEi1\n0.6\n54926 (48.3)\n0.4\n104596 (50.8)\n\n\n\n\n\nACEi dose (mg/24h)1\n52.1\n10.0 [5.0, 15.0]\n49.5\n10.0 [5.0, 15.0]\n\n\n\n\n\nARB1\n1.1\n30970 (27.4)\n0.9\n59400 (29.0)\n\n\n\n\n\nARB dose (mg/24h)1\n73.0\n32.0 [15.0, 50.0]\n71.3\n32.0 [12.5, 50.0]\n\n\n\n\n\nARNi1\n56.0\n6960 (13.8)\n58.6\n11611 (13.6)\n\n\n\n\n\nACEi/ARB/ARNi1\n1.3\n91155 (80.7)\n1.1\n172045 (84.1)\n\n\n\n\n\nBeta-blocker1\n0.5\n98019 (86.1)\n0.4\n180675 (87.8)\n\n\n\n\n\nBeta-blocker dose (mg/24h)1\n14.5\n25.0 [7.5, 100.0]\n12.8\n25.0 [7.5, 100.0]\n\n\n\n\n\nMRA1\n0.9\n42376 (37.4)\n0.6\n79343 (38.6)\n\n\n\n\n\nMRA dose (mg/24h)1\n75.3\n25.0 [25.0, 25.0]\n75.5\n25.0 [25.0, 25.0]\n\n\n\n\n\nDigoxin1\n0.6\n14862 (13.1)\n0.4\n27435 (13.3)\n\n\n\n\n\nPlatelet inhibitor1\n0.6\n44577 (39.2)\n0.5\n80458 (39.1)\n\n\n\n\n\nOral anticoagulant1\n0.6\n52927 (46.6)\n0.5\n99517 (48.4)\n\n\n\n\n\nStatin1\n0.5\n52912 (46.5)\n0.4\n101529 (49.3)\n\n\n\n\n\nNitrate1\n0.7\n15034 (13.2)\n0.5\n26719 (13.0)\n\n\n\n\n\nSGLT2i1\n91.7\n2022 (21.3)\n94.9\n2186 (20.9)\n\n\n\n\n\nSGLT2i dose (mg/24h)1\n98.2\n10.0 [10.0, 10.0]\n98.9\n10.0 [10.0, 10.0]\n\n\n\n\n\nSinus node inhibitor1\n58.3\n248 (0.5)\n61.3\n473 (0.6)\n\n\n\n\n\nDevice therapy1\n1.4\n\n1.7\n\n\n\n\n\n\n    No\n\n93068 (82.5)\n\n164078 (80.8)\n\n\n\n\n\n    Pacemaker\n\n10685 (9.5)\n\n19200 (9.5)\n\n\n\n\n\n    CRT-P\n\n2154 (1.9)\n\n4370 (2.2)\n\n\n\n\n\n    CRT-D\n\n3369 (3.0)\n\n7741 (3.8)\n\n\n\n\n\n    ICD\n\n3524 (3.1)\n\n7669 (3.8)\n\n\n\n\n\nDevice therapy CRT/ICD1\n1.4\n9047 (8.0)\n1.7\n19780 (9.7)\n\n\n\n\n\nChest X-ray1\n37.0\n\n35.2\n\n\n\n\n\n\n    No\n\n18770 (26.0)\n\n36050 (26.9)\n\n\n\n\n\n    Normal\n\n17955 (24.9)\n\n32987 (24.6)\n\n\n\n\n\n    Pulmonary congestion\n\n9713 (13.5)\n\n16557 (12.4)\n\n\n\n\n\n    Cardiomegaly\n\n11934 (16.6)\n\n23395 (17.5)\n\n\n\n\n\n    Pulmonary congestion & cardiomegaly\n\n13718 (19.0)\n\n24955 (18.6)\n\n\n\n\n\nDiabetes1\n10.3\n17712 (17.3)\n9.7\n34450 (18.5)\n\n\n\n\n\nDiabetes1\n28.6\n\n28.6\n\n\n\n\n\n\n    No\n\n65939 (80.8)\n\n118050 (80.0)\n\n\n\n\n\n    Type I\n\n1311 (1.6)\n\n2244 (1.5)\n\n\n\n\n\n    Type II\n\n14397 (17.6)\n\n27337 (18.5)\n\n\n\n\n\nHypertension1\n2.3\n63793 (57.1)\n2.1\n113641 (56.2)\n\n\n\n\n\nAtrial fibrillation/flutter1\n0.7\n59692 (52.6)\n0.6\n106801 (52.0)\n\n\n\n\n\nLung disease1\n2.1\n20034 (17.9)\n2.0\n35327 (17.4)\n\n\n\n\n\nValve disease1\n3.5\n22501 (20.4)\n3.5\n40839 (20.5)\n\n\n\n\n\nDilated cardiomyopathy1\n4.6\n11420 (10.5)\n4.6\n25229 (12.8)\n\n\n\n\n\nRevascularization1\n3.0\n29922 (27.0)\n3.2\n57913 (28.9)\n\n\n\n\n\nValve surgery1\n2.1\n7379 (6.6)\n2.3\n13971 (6.9)\n\n\n\n\n\nECG rythm1\n7.0\n\n6.4\n\n\n\n\n\n\n    Sinus\n\n53466 (50.3)\n\n97645 (50.5)\n\n\n\n\n\n    Atrial fibrillation\n\n40427 (38.0)\n\n71468 (36.9)\n\n\n\n\n\n    PM/Other\n\n12485 (11.7)\n\n24361 (12.6)\n\n\n\n\n\nFollow-up referral HF nurse clinic1\n9.6\n55145 (53.3)\n7.0\n118717 (61.8)\n\n\n\n\n\nFollow-up referral speciality1\n8.0\n\n5.8\n\n\n\n\n\n\n    Hospital\n\n62428 (59.3)\n\n124411 (63.9)\n\n\n\n\n\n    Primary care\n\n38790 (36.9)\n\n64273 (33.0)\n\n\n\n\n\n    Other\n\n4034 (3.8)\n\n6012 (3.1)\n\n\n\n\n\nFollow-up referral speciality Hospital1\n8.0\n62428 (59.3)\n5.8\n124411 (63.9)\n\n\n\n\n\nQoL EQ-5D1\n69.5\n70.0 [50.0, 80.0]\n68.5\n70.0 [50.0, 80.0]\n\n\n\n\n\nQoL EQ-5D1\n69.5\n\n68.5\n\n\n\n\n\n\n    0-25\n\n1646 (4.7)\n\n2924 (4.5)\n\n\n\n\n\n    26-50\n\n8723 (25.0)\n\n15867 (24.4)\n\n\n\n\n\n    51-75\n\n14062 (40.3)\n\n26745 (41.1)\n\n\n\n\n\n    76-100\n\n10424 (29.9)\n\n19531 (30.0)\n\n\n\n\n\nFatigue1\n61.5\n\n60.2\n\n\n\n\n\n\n    At rest\n\n2682 (6.1)\n\n4430 (5.4)\n\n\n\n\n\n    At moderate effort\n\n12247 (27.8)\n\n22021 (26.8)\n\n\n\n\n\n    At more than moderate effort\n\n21839 (49.6)\n\n42634 (51.8)\n\n\n\n\n\n    Unaffected\n\n7239 (16.4)\n\n13191 (16.0)\n\n\n\n\n\nOut of breath1\n61.1\n\n59.8\n\n\n\n\n\n\n    At rest\n\n1491 (3.3)\n\n2357 (2.8)\n\n\n\n\n\n    At moderate effort\n\n13459 (30.2)\n\n24267 (29.2)\n\n\n\n\n\n    At more than moderate effort\n\n22848 (51.3)\n\n44385 (53.4)\n\n\n\n\n\n    Unaffected\n\n6750 (15.2)\n\n12111 (14.6)\n\n\n\n\n\nMobilty1\n60.9\n\n59.8\n\n\n\n\n\n\n    Bedridden\n\n579 (1.3)\n\n820 (1.0)\n\n\n\n\n\n    Some problem\n\n20179 (45.2)\n\n35933 (43.2)\n\n\n\n\n\n    No problem\n\n23931 (53.6)\n\n46384 (55.8)\n\n\n\n\n\nHygiene1\n61.2\n\n60.0\n\n\n\n\n\n\n    Can't wash and clothe\n\n925 (2.1)\n\n1292 (1.6)\n\n\n\n\n\n    Some problem\n\n5234 (11.8)\n\n8468 (10.2)\n\n\n\n\n\n    No problem\n\n38230 (86.1)\n\n72892 (88.2)\n\n\n\n\n\nMain activities1\n61.4\n\n60.2\n\n\n\n\n\n\n    Can't do\n\n2276 (5.2)\n\n3616 (4.4)\n\n\n\n\n\n    Some problem\n\n12052 (27.3)\n\n21732 (26.4)\n\n\n\n\n\n    No problem\n\n29829 (67.6)\n\n56887 (69.2)\n\n\n\n\n\nPain1\n62.7\n\n61.4\n\n\n\n\n\n\n    Severe\n\n2712 (6.4)\n\n4743 (6.0)\n\n\n\n\n\n    Moderate\n\n19140 (44.9)\n\n35708 (44.8)\n\n\n\n\n\n    None\n\n20780 (48.7)\n\n39256 (49.3)\n\n\n\n\n\nAnxiety/Depression1\n64.2\n\n62.9\n\n\n\n\n\n\n    Severe\n\n1835 (4.5)\n\n3155 (4.1)\n\n\n\n\n\n    Moderate\n\n15017 (36.7)\n\n28028 (36.5)\n\n\n\n\n\n    None\n\n24085 (58.8)\n\n45555 (59.4)\n\n\n\n\n\nBMI (kg/m²)1\n38.2\n26.3 [23.3, 30.2]\n32.6\n26.7 [23.6, 30.5]\n\n\n\n\n\nBMI (kg/m²) ≥301\n38.2\n18566 (26.3)\n32.5\n39078 (28.0)\n\n\n\n\n\nAge (years)1\n0.0\n\n0.0\n\n\n\n\n\n\n    <70\n\n30727 (26.9)\n\n62624 (30.3)\n96349 (22.8)\n125509 (32.3)\n190209 (24.3)\n\n\n    70-80\n\n39316 (34.4)\n\n75073 (36.3)\n129929 (30.7)\n148752 (38.3)\n254503 (32.5)\n\n\n    >80\n\n44332 (38.8)\n\n68937 (33.4)\n196598 (46.5)\n114577 (29.5)\n337510 (43.1)\n\n\nPrevious HFH < 1 year12\n0.0\n66506 (58.1)\n0.0\n115625 (56.0)\n287370 (68.0)\n0 (0.0)\n0 (0.0)\n\n\nAtrial fibrillation/flutter12\n0.0\n67696 (59.2)\n0.0\n120790 (58.5)\n186607 (44.1)\n26061 (6.7)\n51634 (6.6)\n\n\nIHD12\n0.0\n61627 (53.9)\n0.0\n113161 (54.8)\n191730 (45.3)\n50542 (13.0)\n105655 (13.5)\n\n\nHypertension12\n0.0\n77441 (67.7)\n0.0\n137681 (66.6)\n218197 (51.6)\n83447 (21.5)\n148166 (18.9)\n\n\nDiabetes12\n0.0\n31118 (27.2)\n0.0\n57402 (27.8)\n96482 (22.8)\n31969 (8.2)\n57754 (7.4)\n\n\nValve disease12\n0.0\n30732 (26.9)\n0.0\n55720 (27.0)\n64165 (15.2)\n7756 (2.0)\n13740 (1.8)\n\n\nCountry of birth3\n0.0\n\n0.0\n\n\n\n\n\n\n    Sweden\n\n98473 (86.1)\n\n176223 (85.3)\n370296 (87.6)\n338660 (87.1)\n695921 (89.0)\n\n\n    Europe\n\n12364 (10.8)\n\n23606 (11.4)\n42098 (10.0)\n37013 (9.5)\n66666 (8.5)\n\n\n    Other\n\n3536 (3.1)\n\n6802 (3.3)\n10471 (2.5)\n13134 (3.4)\n19586 (2.5)\n\n\nChildren3\n0.0\n95795 (83.8)\n0.0\n172849 (83.6)\n350314 (82.8)\n329013 (84.6)\n654789 (83.7)\n\n\nMarital status Single/widowed/divorced3\n0.1\n61993 (54.2)\n0.1\n108224 (52.4)\n246424 (58.4)\n183019 (47.1)\n415532 (53.2)\n\n\nFamily type Living alone3\n0.1\n57758 (50.5)\n0.1\n99991 (48.4)\n232291 (55.0)\n168464 (43.4)\n391402 (50.1)\n\n\nEducation3\n2.1\n\n2.1\n\n\n\n\n\n\n    Compulsory school\n\n50010 (44.7)\n\n88400 (43.7)\n206616 (51.1)\n145477 (38.1)\n345641 (46.0)\n\n\n    Secondary school\n\n43213 (38.6)\n\n79798 (39.4)\n140319 (34.7)\n147189 (38.5)\n263179 (35.0)\n\n\n    University\n\n18697 (16.7)\n\n34143 (16.9)\n57729 (14.3)\n89221 (23.4)\n142223 (18.9)\n\n\nDisposable income (100 SEK)3\n0.1\n1534.0 [1226.0, 2041.0]\n0.1\n1545.0 [1236.0, 2076.0]\n1365.0 [1055.0, 1783.0]\n1653.0 [1269.0, 2478.0]\n1408.0 [1061.0, 1963.0]\n\n\nDuration of HF (days)2\n0.0\n303.0 [14.0, 1736.0]\n0.0\n343.0 [18.0, 1883.0]\n0.0 [0.0, 101.0]\n\n\n\n\nTime since last HF hospitalization (days)2\n40.8\n20.0 [0.0, 264.0]\n40.4\n22.0 [0.0, 287.0]\n0.0 [0.0, 0.0]\n\n\n\n\nLocation2\n0.0\n\n0.0\n\n\n\n\n\n\n    HF in-patient\n\n29379 (25.7)\n\n51246 (24.8)\n287370 (68.0)\n\n\n\n\n    Other in-patient\n\n16270 (14.2)\n\n24942 (12.1)\n13696 (3.2)\n\n\n\n\n    Out-patient\n\n68726 (60.1)\n\n130446 (63.1)\n121810 (28.8)\n\n\n\n\nHypertension2\n0.0\n67327 (58.9)\n0.0\n118776 (57.5)\n218197 (51.6)\n83447 (21.5)\n148166 (18.9)\n\n\nDiabetes2\n0.0\n29925 (26.2)\n0.0\n54888 (26.6)\n96482 (22.8)\n31969 (8.2)\n57754 (7.4)\n\n\nIschemic heart disease2\n0.0\n60454 (52.9)\n0.0\n110900 (53.7)\n190114 (45.0)\n50209 (12.9)\n105218 (13.5)\n\n\nMyocardial infarction2\n0.0\n44249 (38.7)\n0.0\n81357 (39.4)\n130249 (30.8)\n27019 (6.9)\n54342 (6.9)\n\n\nAngina pectoris2\n0.0\n22181 (19.4)\n0.0\n41455 (20.1)\n77036 (18.2)\n15463 (4.0)\n35088 (4.5)\n\n\nPCI2\n0.0\n21899 (19.1)\n0.0\n41645 (20.2)\n47489 (11.2)\n16445 (4.2)\n23714 (3.0)\n\n\nCABG2\n0.0\n28938 (25.3)\n0.0\n55861 (27.0)\n65972 (15.6)\n20000 (5.1)\n29752 (3.8)\n\n\nDilated cardiomyopathy2\n0.0\n9953 (8.7)\n0.0\n22104 (10.7)\n13639 (3.2)\n0 (0.0)\n0 (0.0)\n\n\nPeripheral artery disease2\n0.0\n10968 (9.6)\n0.0\n18865 (9.1)\n34563 (8.2)\n10077 (2.6)\n19198 (2.5)\n\n\nAtrial fibrillation/flutter2\n0.0\n62870 (55.0)\n0.0\n111846 (54.1)\n186607 (44.1)\n26061 (6.7)\n51634 (6.6)\n\n\nStroke2\n0.0\n18149 (15.9)\n0.0\n30719 (14.9)\n70420 (16.7)\n33721 (8.7)\n77571 (9.9)\n\n\nTIA2\n0.0\n4109 (3.6)\n0.0\n7105 (3.4)\n15546 (3.7)\n8388 (2.2)\n17945 (2.3)\n\n\nStroke/TIA2\n0.0\n20666 (18.1)\n0.0\n35136 (17.0)\n79946 (18.9)\n39439 (10.1)\n89741 (11.5)\n\n\nValvular disease2\n0.0\n23871 (20.9)\n0.0\n42582 (20.6)\n64165 (15.2)\n7756 (2.0)\n13740 (1.8)\n\n\nRenal failure2\n0.0\n19467 (17.0)\n0.0\n32496 (15.7)\n49689 (11.8)\n7026 (1.8)\n11962 (1.5)\n\n\nHyperkalemia2\n0.0\n2500 (2.2)\n0.0\n4333 (2.1)\n4706 (1.1)\n602 (0.2)\n1053 (0.1)\n\n\nHypokalemia2\n0.0\n3174 (2.8)\n0.0\n5136 (2.5)\n9876 (2.3)\n2081 (0.5)\n4182 (0.5)\n\n\nDialysis2\n0.0\n1131 (1.0)\n0.0\n1863 (0.9)\n4464 (1.1)\n647 (0.2)\n1036 (0.1)\n\n\nCOPD2\n0.0\n16169 (14.1)\n0.0\n28419 (13.8)\n51011 (12.1)\n10675 (2.7)\n19835 (2.5)\n\n\nPneumonia/Flue/Respiratory infection2\n0.0\n42328 (37.0)\n0.0\n73936 (35.8)\n151531 (35.8)\n36286 (9.3)\n72903 (9.3)\n\n\nLiver disease2\n0.0\n2609 (2.3)\n0.0\n4680 (2.3)\n7973 (1.9)\n2683 (0.7)\n4199 (0.5)\n\n\nObstructive sleep apnea2\n0.0\n4869 (4.3)\n0.0\n9503 (4.6)\n10726 (2.5)\n5483 (1.4)\n7027 (0.9)\n\n\nDementia2\n0.0\n2998 (2.6)\n0.0\n3838 (1.9)\n18772 (4.4)\n13962 (3.6)\n36467 (4.7)\n\n\nDepression2\n0.0\n4464 (3.9)\n0.0\n7701 (3.7)\n15492 (3.7)\n8931 (2.3)\n17266 (2.2)\n\n\nMalignant cancer within 3 years2\n0.0\n15045 (13.2)\n0.0\n25958 (12.6)\n54617 (12.9)\n43057 (11.1)\n79708 (10.2)\n\n\nMuscoloskeletal/connective tissue diseases within 3 years2\n0.0\n37283 (32.6)\n0.0\n66206 (32.0)\n124052 (29.3)\n77639 (20.0)\n137759 (17.6)\n\n\nAlcohol abuse2\n0.0\n3654 (3.2)\n0.0\n6566 (3.2)\n10900 (2.6)\n5618 (1.4)\n8427 (1.1)\n\n\nSevere bleeding2\n0.0\n22922 (20.0)\n0.0\n39016 (18.9)\n72037 (17.0)\n26950 (6.9)\n53017 (6.8)\n\n\nCharlson Comorbidity Index2\n0.0\n3.0 [1.0, 4.0]\n0.0\n3.0 [1.0, 4.0]\n3.0 [1.0, 4.0]\n0.0 [0.0, 2.0]\n0.0 [0.0, 2.0]\n\n\nCharlson Comorbidity Index2\n0.0\n\n0.0\n\n\n\n\n\n\n    0-1\n\n29521 (25.8)\n\n55409 (26.8)\n115662 (27.4)\n276348 (71.1)\n569447 (72.8)\n\n\n    2-3\n\n42102 (36.8)\n\n77627 (37.6)\n171369 (40.5)\n80492 (20.7)\n157568 (20.1)\n\n\n    4-7\n\n34525 (30.2)\n\n59881 (29.0)\n112854 (26.7)\n26414 (6.8)\n46081 (5.9)\n\n\n    ≥8\n\n8227 (7.2)\n\n13717 (6.6)\n22991 (5.4)\n5584 (1.4)\n9126 (1.2)\n\n\nHeart failure hospitalization2\n0.0\n31555 (27.6)\n0.0\n77994 (37.7)\n145770 (34.5)\n0 (0.0)\n0 (0.0)\n\n\nNumber of heart failure hospitalizations2\n0.0\n0.0 [0.0, 1.0]\n0.0\n0.0 [0.0, 1.0]\n0.0 [0.0, 1.0]\n0.0 [0.0, 0.0]\n0.0 [0.0, 0.0]\n\n\nAny hospitalization2\n0.0\n79304 (69.3)\n0.0\n154397 (74.7)\n320292 (75.7)\n199583 (51.3)\n478972 (61.2)\n\n\nCV hospitalization2\n0.0\n52581 (46.0)\n0.0\n112733 (54.6)\n226587 (53.6)\n67618 (17.4)\n172962 (22.1)\n\n\nNon-CV hospitalization2\n0.0\n63308 (55.4)\n0.0\n123023 (59.5)\n261438 (61.8)\n177818 (45.7)\n429948 (55.0)\n\n\nStroke/TIA hospitalization2\n0.0\n8457 (7.4)\n0.0\n16164 (7.8)\n40004 (9.5)\n28959 (7.4)\n78911 (10.1)\n\n\nMyocardial infarction hospitalization2\n0.0\n6029 (5.3)\n0.0\n12647 (6.1)\n34612 (8.2)\n10723 (2.8)\n29969 (3.8)\n\n\nIschemic heart disease hospitalization2\n0.0\n10683 (9.3)\n0.0\n24304 (11.8)\n56005 (13.2)\n15725 (4.0)\n41744 (5.3)\n\n\nVentricular fibrillation/tachycardia hospitalization2\n0.0\n1321 (1.2)\n0.0\n3953 (1.9)\n4785 (1.1)\n223 (0.1)\n524 (0.1)\n\n\nPneumonia/Flue/Respiratory infection hospitalization2\n0.0\n19445 (17.0)\n0.0\n39431 (19.1)\n89403 (21.1)\n30443 (7.8)\n79891 (10.2)\n\n\nPneumonia hospitalization2\n0.0\n12959 (11.3)\n0.0\n26420 (12.8)\n58778 (13.9)\n22892 (5.9)\n60174 (7.7)\n\n\nRenal failure hospitalization2\n0.0\n6471 (5.7)\n0.0\n13711 (6.6)\n25296 (6.0)\n4574 (1.2)\n10094 (1.3)\n\n\nMalignant cancer hospitalization2\n0.0\n8037 (7.0)\n0.0\n14449 (7.0)\n35025 (8.3)\n37816 (9.7)\n91528 (11.7)\n\n\nSevere bleeding hospitalization2\n0.0\n16292 (14.2)\n0.0\n32475 (15.7)\n64957 (15.4)\n33183 (8.5)\n81045 (10.4)\n\n\nHyperkalemia hospitalization2\n0.0\n683 (0.6)\n0.0\n1715 (0.8)\n2825 (0.7)\n235 (0.1)\n532 (0.1)\n\n\nHypokalemia hospitalization2\n0.0\n322 (0.3)\n0.0\n816 (0.4)\n1345 (0.3)\n542 (0.1)\n1195 (0.2)\n\n\nSyncope hospitalization2\n0.0\n2691 (2.4)\n0.0\n6094 (2.9)\n12114 (2.9)\n6400 (1.6)\n17134 (2.2)\n\n\nTrauma hospitalization2\n0.0\n14517 (12.7)\n0.0\n27837 (13.5)\n65663 (15.5)\n44297 (11.4)\n130595 (16.7)\n\n\nCoronary revascularization2\n0.0\n3708 (3.2)\n0.0\n8998 (4.4)\n18924 (4.5)\n8890 (2.3)\n17394 (2.2)\n\n\nDeath2\n0.0\n64876 (56.7)\n0.0\n112286 (54.3)\n300917 (71.2)\n127556 (32.8)\n406620 (52.0)\n\n\nCV death2\n0.0\n38524 (33.7)\n0.0\n68541 (33.2)\n178361 (42.2)\n40123 (10.3)\n145478 (18.6)\n\n\nNon-CV death2\n0.0\n26352 (23.0)\n0.0\n43745 (21.2)\n122556 (29.0)\n87433 (22.5)\n261142 (33.4)\n\n\nHospitalization or death Sudden cardiac death2\n0.0\n59 (0.1)\n0.0\n110 (0.1)\n346 (0.1)\n99 (0.0)\n542 (0.1)\n\n\nComposite CVD/HFH2\n0.0\n53843 (47.1)\n0.0\n106812 (51.7)\n247007 (58.4)\n40123 (10.3)\n145478 (18.6)\n\n\nComposite Death/HFH2\n0.0\n72271 (63.2)\n0.0\n132076 (63.9)\n329180 (77.8)\n127556 (32.8)\n406620 (52.0)\n\n\n\nNote: \n\n\n\n\n\n\n\n\n\n Patients have different follow-up times, this means that outcomes can not be interpreted directly from the table.\n\n\n\n\n\n\n\n\n\n Categorical variables are presented with n (%) and continuous variables with median [q1-q3].\n\n\n\n\n\n\n\n\n\n1 Source: SwedeHF\n\n\n\n\n\n\n\n\n\n2 Source: NPR\n\n\n\n\n\n\n\n\n\n3 Source: SCB" + }, + { + "objectID": "index.html", + "href": "index.html", + "title": "SwedeHF database 4 (SHFDB4)", + "section": "", + "text": "Github\n \n \n \n Contact\n \n\n\n \n\n\n\nSwedeHF database 4 (SHFDB4)\nA Heart Failure cohort from Sweden 2000 - 2021. The population consists of\n\npatients recorded in the Swedish Heart Failure Registry (SwedeHF),\npatients recorded in the National Patient Register with a ICD-10 code in main position for HF and\ngender, year of birth and county of residence matched HF-free controls.\n\nPlease feel free to contact me if you have any questions.\n\nView/download the R code for the database" + }, + { + "objectID": "datasources/index.html", + "href": "datasources/index.html", + "title": "Data Sources", + "section": "", + "text": "The Swedish Heart Failure Registry (SwedeHF) (Swedish: RiksSvikt) is managed by Uppsala Clinical Research Center (UCR).\nSwedeHF is a health quality and research registry that started in 2000 and became nationwide 2003. In 2021 31.5% of the prevalent heart failure population in Sweden were at some point registered in SwedeHF. Coverage is lower in primary care but few patients are seen exclusively in primary care and are therefore caught and registered in cardiology or internal medicine.\nUp until April 2017 the only inclusion criterion was clinician-judged Heart Failure (HF). From April 2017 the inclusion criteria are ICD-10: I50.0, I50.1, I50.9, I42.0, I42.6, I42.7, I25.5, I11.0, I13.0, I13.2.\nThe new version of SwedeHF also entailed other differences, mainly how data is collected. Previously there were no restrictions of what visits could be registered. In the new SwedeHF an index visits (the first time a patient is registered into SwedeHF) is registered and thereafter a follow-up visit within 6 months and thereafter yearly follow-ups. The yearly follow-ups can be either out-patient visits, telephone contact or survey. Only the first visit can be a hospitalization, this means that the proportion of hospitalized patients have decreased since April 2017.\nFor more information, see https://www.ucr.uu.se/rikssvikt-en/ and https://pubmed.ncbi.nlm.nih.gov/30092697/." + }, + { + "objectID": "datasources/index.html#the-swedish-heart-failure-registry-swedehf", + "href": "datasources/index.html#the-swedish-heart-failure-registry-swedehf", + "title": "Data Sources", + "section": "", + "text": "The Swedish Heart Failure Registry (SwedeHF) (Swedish: RiksSvikt) is managed by Uppsala Clinical Research Center (UCR).\nSwedeHF is a health quality and research registry that started in 2000 and became nationwide 2003. In 2021 31.5% of the prevalent heart failure population in Sweden were at some point registered in SwedeHF. Coverage is lower in primary care but few patients are seen exclusively in primary care and are therefore caught and registered in cardiology or internal medicine.\nUp until April 2017 the only inclusion criterion was clinician-judged Heart Failure (HF). From April 2017 the inclusion criteria are ICD-10: I50.0, I50.1, I50.9, I42.0, I42.6, I42.7, I25.5, I11.0, I13.0, I13.2.\nThe new version of SwedeHF also entailed other differences, mainly how data is collected. Previously there were no restrictions of what visits could be registered. In the new SwedeHF an index visits (the first time a patient is registered into SwedeHF) is registered and thereafter a follow-up visit within 6 months and thereafter yearly follow-ups. The yearly follow-ups can be either out-patient visits, telephone contact or survey. Only the first visit can be a hospitalization, this means that the proportion of hospitalized patients have decreased since April 2017.\nFor more information, see https://www.ucr.uu.se/rikssvikt-en/ and https://pubmed.ncbi.nlm.nih.gov/30092697/." + }, + { + "objectID": "datasources/index.html#longitudinal-integrated-database-for-health-insurance-and-labour-market-studies-lisa", + "href": "datasources/index.html#longitudinal-integrated-database-for-health-insurance-and-labour-market-studies-lisa", + "title": "Data Sources", + "section": "Longitudinal integrated database for health insurance and labour market studies (LISA)", + "text": "Longitudinal integrated database for health insurance and labour market studies (LISA)\nThe Longitudinal database on socio-economic factors (LISA) is managed by Statistics Sweden (SCB). Information on socio-economic factors (education, income, civil status) is received from LISA.\nFor more information, see LISA and https://pubmed.ncbi.nlm.nih.gov/30929112/." + }, + { + "objectID": "datasources/index.html#register-of-the-total-population", + "href": "datasources/index.html#register-of-the-total-population", + "title": "Data Sources", + "section": "Register of the Total Population", + "text": "Register of the Total Population\nRegister of the Total Population (Swedish: Registret över totalbefolkningen, RTB) is managed by Statistics Sweden (SCB).\nInformation on number of children, country of birth and immigration/emigration is received from here." + }, + { + "objectID": "datasources/index.html#the-national-cancer-register", + "href": "datasources/index.html#the-national-cancer-register", + "title": "Data Sources", + "section": "The National Cancer Register", + "text": "The National Cancer Register\nThe Swedish Cancer Register (Swedish: Cancerregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen).\nThe Swedish Cancer Register was founded in 1958 and it is compulsory for every health care provider to report newly detected cancer cases to the registry. For more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-cancer-register/.\nNo information from the Swedish Cancer Register is included in the base version of SHFDB4 but information from the register can be added upon request." + }, + { + "objectID": "datasources/index.html#the-national-patient-register", + "href": "datasources/index.html#the-national-patient-register", + "title": "Data Sources", + "section": "The National Patient Register", + "text": "The National Patient Register\nThe National Patient Register (NPR) (Swedish: Patientregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen).\nFrom 1987 the NPR includes all in-patient care in Sweden. Since 1997 it also covers out-patient surgical procedures and from 2001 also out-patient visits in speciality (but not primary) care. Each record contains medical information on surgical procedures, hospital department and discharge diagnoses coded according to International Classification of Diseases (ICD-9 for years 1987-1996 and ICD-10 for years 1997-, except for Skåne were ICD-10 was introduced 1998). The validity of HF diagnosis in cardiology and non-cardiology clinics in Sweden is 91% and 86%, respectively (https://pubmed.ncbi.nlm.nih.gov/15916919). For more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-patient-register/.\nFrom the NPR individual comorbidities (variables beginning with sos_com_) and hospitalization outcomes (variables beginning with sos_out_hosp) were calculated as well as the Charlson Comorbidity Index. Additional comorbidities and outcomes can be made available upon request." + }, + { + "objectID": "datasources/index.html#the-cause-of-death-register", + "href": "datasources/index.html#the-cause-of-death-register", + "title": "Data Sources", + "section": "The Cause of Death Register", + "text": "The Cause of Death Register\nThe Cause of Death Register (Swedish: Dödsorsaksregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and contains data on causes of death from 1961. For more information, see https://www.socialstyrelsen.se/statistik-och-data/register/dodsorsaksregistret/ (information only available in Swedish).\nFrom the Cause of Death Register deaths (variables beginning with sos_out_death) were calculated. Additional casuses of death can be made available upon request." + }, + { + "objectID": "datasources/index.html#the-national-prescribed-drug-register", + "href": "datasources/index.html#the-national-prescribed-drug-register", + "title": "Data Sources", + "section": "The National Prescribed Drug Register", + "text": "The National Prescribed Drug Register\nThe National Prescribed Drug Register (Swedish: Läkemedelsregistret) is managed by The National Board of Health and Welfare (Socialstyrelsen) and from July 2005 includes all dispensed drugs.\nFor more information, see https://www.socialstyrelsen.se/en/statistics-and-data/registers/national-prescribed-drug-register/.\nNo information from the Prescribed Drug Register is included in the base version of SHFDB4 but information from the register can be added upon request." + }, + { + "objectID": "datasources/index.html#primary-care-data-from-region-stockholm", + "href": "datasources/index.html#primary-care-data-from-region-stockholm", + "title": "Data Sources", + "section": "Primary care data from Region Stockholm", + "text": "Primary care data from Region Stockholm\nVAL/KON is managed by Region Stockholm and contains information on healthcare from providers that have an agreement with Region Stockholm. For more information, see www.gups.sll.se/val/Valhandbok.docx.\nNo information from VAL/KON is included in the base version of SHFDB4 but information on certain diagnosis in primary care are available and can be added upon request." + }, + { + "objectID": "datasources/index.html#swedish-national-diabetes-register-ndr", + "href": "datasources/index.html#swedish-national-diabetes-register-ndr", + "title": "Data Sources", + "section": "Swedish National Diabetes Register (NDR)", + "text": "Swedish National Diabetes Register (NDR)\nThe Swedish National Diabetes Register (NDR) is a national quality register for children and adults with diabetes. For more information, see https://www.ndr.nu/.\nNo information from NDR is included in the base version of SHFDB4 but information can be added upon request." + }, + { + "objectID": "datasources/index.html#swedish-icd-pacemaker-registry", + "href": "datasources/index.html#swedish-icd-pacemaker-registry", + "title": "Data Sources", + "section": "Swedish ICD & Pacemaker Registry", + "text": "Swedish ICD & Pacemaker Registry\nThe Swedish ICD & Pacemaker Registry is a national quality register. For more information, see https://www.pacemakerregistret.se/.\nNo information from ICD & Pacemaker Registry is included in the base version of SHFDB4 but information can be added upon request." + }, + { + "objectID": "definitions/index.html#index-date", + "href": "definitions/index.html#index-date", + "title": "Definitions", + "section": "Index date", + "text": "Index date\nIndex date is defined as the registered date of discharge for in-patients and date of admission for out-patients in SwedeHF. For the patients identified through the National Patient Register with ICD codes the index date is defined as the first occurrence of a diagnosis of HF in main position. The controls receive the same index date as their matched case." + }, + { + "objectID": "definitions/index.html#follow-up", + "href": "definitions/index.html#follow-up", + "title": "Definitions", + "section": "Follow-up", + "text": "Follow-up\nThe follow-up period is defined as time from index date to emigration, death or end of follow-up, 2021-12-31, whichever came first.\nFor the controls the follow-up period is defined as time from the matched cases index date to heart failure diagnosis (either in NPR or SwedeHF), emigration, death or end of follow-up, 2021-12-31, whichever came first." + }, + { + "objectID": "definitions/index.html#socio-economic-variables", + "href": "definitions/index.html#socio-economic-variables", + "title": "Definitions", + "section": "Socio-economic variables", + "text": "Socio-economic variables\nThe socio-economic variables from LISA, Statistics Sweden, are from the year prior to the index year, so a patient with an index date 2015-03-06 will have income, marriage status and education from 2014.\nLimitations: Unmarried persons cohabiting without children are classified as Living alone. Education is not registered for individuals < 25 years." + }, + { + "objectID": "definitions/index.html#comorbidities-and-outcomes", + "href": "definitions/index.html#comorbidities-and-outcomes", + "title": "Definitions", + "section": "Comorbidities and outcomes", + "text": "Comorbidities and outcomes\nFor all comorbidities and hospitalizations from the NPR date of admission/visit (INDATUM) is used to calculate if it is a comorbidity or outcome. Adjoining hospitalizations, where the discharge date of the former hospitalization is the same as the admission date of the latter, are merged together into one hospitalization in order to take into account possible transferrals between wards/hospitals.\nLimitation: For the comorbidities MI, IHD, Stroke, CABG and PCI there is no time restriction applied. There is no data prior to 1987 (for PCI, CABG only from 1997) and the earlier registrations will therefore not have had the possibility to accumulate comorbidities to the same extent as the latter. For more details see Data Sources)).\nLimitation: Out-patient visits in speciality (but not primary) care are covered from 2001. Therefore, for the earlier visits, these are (partially) not included in the comorbidities.\n\n\n\n\n\nVariable\nCode\nRegister\nPosition\nPeriod\n\n\n\n\nsos_com_hypertension\nICD:I10-5\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_diabetes\nICD:E10-4\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_ihd\nICD:410-4, I20-5\nNPR (in+out)\nAll DIA\n-0\n\n\nsos_com_mi\nICD:410, 412, I21, I22, I252\nNPR (in+out)\nAll DIA\n-0\n\n\nsos_com_angina\nICD:I20\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_pci\nOP:FNG\nNPR (in+out)\nAll OP\n-0\n\n\nsos_com_cabg\nICD:Z951, Z955 OP:FNA, FNB, FNC, FND, FNE, FNF, FNH\nNPR (in+out)\nAll DIA All OP\n-0\n\n\nsos_com_dcm\nICD:I420\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_pad\nICD:I70-3\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_af\nICD:I48\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_stroke\nICD:430-4, 438, I60-4, I690-4\nNPR (in+out)\nAll DIA\n-0\n\n\nsos_com_tia\nICD:G45\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_valvular\nICD:I05-8, I34-9, Q22, Q230-3, Q230-3, Q235-9, Z952-4\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_renal\nICD:N17-9, Z491, Z492 OP:KAS00, KAS10, KAS20, DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35\nNPR (in+out)\nAll DIA All OP\n-5yrs-0\n\n\nsos_com_hyperkalemia\nICD:E875\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_hypokalemia\nICD:E876\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_dialysis\nICD:Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35\nNPR (in+out)\nAll DIA All OP\n-5yrs-0\n\n\nsos_com_copd\nICD:J40-4\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_respiratory\nICD:J\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_liver\nICD:B18, I85, I864, I982, K70, K710, K711, K713-7, K72-4, K760, K762-9\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_sleepapnea\nICD:G473\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_dementia\nICD:F00-4, R54\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_depression\nICD:F32-4\nNPR (in+out)\nAll DIA\n-5yrs-0\n\n\nsos_com_cancer3y\nICD:C\nNPR (in+out)\nHDIA\n-3yrs-0\n\n\nsos_com_muscoloskeletal3y\nICD:M\nNPR (in+out)\nAll DIA\n-3yrs-0\n\n\nsos_com_alcohol\nICD:E244, E52, F10, G312, G621, G721, I426, K292, K70, K860, O354, P043, Q860, T51, Z502, Z714 Ekod:Y90, Y91\nNPR (in+out)\nAll DIA All Ekod\n-5yrs-0\n\n\nsos_com_bleed\nICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029\nNPR (in+out)\nAll DIA All OP\n-5yrs-0\n\n\nsos_out_hosphf\nICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428\nNPR (in)\nHDIA\n1-\n\n\nsos_out_counthosphf\nICD:I110, I130, I132, I255, I420, I423, I425, I426, I427, I428, I429, I43, I50, J81, K761, R570, 414W, 425E, 425F, 425G, 425H, 425W, 425X, 428\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospany\nICD:\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospcv\nICD:I, J81, K761, G45, R570\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospnoncv\nICD:Not I, J81, K761, G45, R570\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospstroketia\nICD:I60-4, G45\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospmi\nICD:I21, I22\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospihd\nICD:I20-5\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospventfib\nICD:I490, I472\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospscd\nICD:I461\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosprespiratory\nICD:J\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosppneumonia\nICD:J09, J10-8\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosprenal\nICD:N17-9, KAS00, KAS10, KAS20, Z491, Z492 OP:DR014, DR015, DR016, DR020, DR012, DR013, DR023, DR024, TJA33, TJA35\nNPR (in)\nHDIA All OP\n1-\n\n\nsos_out_hospcancer\nICD:C\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospbleed\nICD:S064, S065, S066, I850, I983, K226, K250, K252, K254, K256, K260, K262, K264, K266, K270, K272, K274, K276, K280, K284, K286, K290, K625, K661, K920, K921, K922, H431, N02, R04, R58, T810, D629 OP:DR029\nNPR (in)\nHDIA All OP\n1-\n\n\nsos_out_hosphyperkalemia\nICD:E875\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosphypokalemia\nICD:E876\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hospsyncope\nICD:R55\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosptrauma\nICD:S, T0, T10-4\nNPR (in)\nHDIA\n1-\n\n\nsos_out_hosprevasc\nOP:FNG, FNA, FNB, FNC, FND, FNE, FNF, FNH\nNPR (in)\nAll OP\n1-\n\n\nsos_out_deathcv\nICD:I, J81, K761, R570, G45\nCause of Death\nULORSAK\n\n\n\nsos_out_deathscd\nICD:I461\nCause of Death\nULORSAK" + }, + { + "objectID": "definitions/index.html#charlson-comorbidity-index", + "href": "definitions/index.html#charlson-comorbidity-index", + "title": "Definitions", + "section": "Charlson comorbidity index", + "text": "Charlson comorbidity index\nThe ICD-9/10 codes used are not necessarily the same as in the other comorbidities and outcomes but from https://www.dovepress.com/articles.php?article_id=61144.\n\n\n\n\n\nVariable\nCode\nRegister\nPosition\nPeriod\n\n\n\n\nsos_com_cci_mi\nICD:410, 412, I21, I22, I252\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_chf\nICD:402A, 402B, 402X, 404A, 404B, 404X, 425E, 425F, 425H, 425W, 425X, 428, I110, I130, I132, I255, I420, I426-9, I43, I50\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_pvd\nICD:440, 441, 443B, 443X, 447B, 557, I70, I71, I731, I738, I739, I771, I790, I792, K55\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_cd\nICD:430-8, G45, I60-4, I67, I69\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_copd\nICD:491, 492, 496, J43-4\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_copdother\nICD:490, 493-5, 500-8, 516, 517, J41, J42, J45-7, J60-9, J70\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_rheumatic\nICD:446, 696A, 710A-E, 714, 719D, 720, 725, M05, M06, M123, M070-3, M08, M13, M30, M313-6, M32, M33, M34, M350, M351, M353, M45, M46\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_dementia\nICD:290, 294B, 331A-C, 331X, F00-3, F051, G30, G311, G319\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_plegia\nICD:342, 343, 344A-F, G114, G80-2, G830-3, G838\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_diabetes\nICD:250A-C, E100, E101, E110, E111, E120, E121, E130, E131, E140, E141\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_diabetescompliation\nICD:250D-G, E102-5, E107, E112-7, E122-7, E132-7, E142-7\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_renal\nICD:403A, 403B, 403X, 582, 583, 585, 586, 588A, V42A, V45B, V56, N032-7, N052-7, N11, N18, N19, N250, I120, I131, Q611-4, Z49, Z940, Z992\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_livermild\nICD:070, 571C, 571E, 571F, 573, B15-9, K703, K73, K746, K703, K754\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_liverspec\nICD:789F, R18\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_livermodsev\nICD:789F, 456A-C, 572D-E, 572C, R18, I850, I859, I982, I983\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_pud\nICD:531-4, K25-8\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_malignancy\nICD:14-9, 200-8, C0-7, C80-6, C88-9, C90-7\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_metastatictumor\nICD:196-8, 199A, 199B, C77-9, C80\nNPR (in+out)\nAll DIA\n-10yrs-0\n\n\nsos_com_cci_hiv\nICD:079J, 279K, B20-4, F024, O987, R75, Z114, Z219, Z711\nNPR (in+out)\nAll DIA\n-10yrs-0" + }, + { + "objectID": "population/index.html#patients-registered-in-swedehf", + "href": "population/index.html#patients-registered-in-swedehf", + "title": "Population", + "section": "Patients registered in SwedeHF", + "text": "Patients registered in SwedeHF\nAll patients recorded in SwedeHF are included." + }, + { + "objectID": "population/index.html#patients-with-hf-from-the-national-patient-register", + "href": "population/index.html#patients-with-hf-from-the-national-patient-register", + "title": "Population", + "section": "Patients with HF from the National Patient Register", + "text": "Patients with HF from the National Patient Register\nPatients with an ICD-10 code for HF in main position in the National Patient Register (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761) starting from 2000-01-01 with no previous ICD-9/10 code for HF (I110 I130 I132 I255 I420 I423 1425 I426 I427 I428 I429 I43 I50 J81 K761 ICD-9: 414W 425E 425F 425G 425H 425W 425X 428) since 1987." + }, + { + "objectID": "population/index.html#hf-free-controls", + "href": "population/index.html#hf-free-controls", + "title": "Population", + "section": "HF-free controls", + "text": "HF-free controls\nFor each post in SwedeHF or the first date in the National Patient Register a set of controls was chosen by Statistics Sweden in a ratio of 2:1. Since a person can have more than one registered post in SwedeHF a patient can have more than 2 controls in total, up to 2 for each posts.\nEligible controls were persons without re-used Swedish personal identity numbers (PINs) and free of HF, defined either in the National Patient registry (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761, R570, ICD-9: 414W, 425E-H, 425W, 425X, 428) or SwedeHF, at the end of the year of the index date for the case and matched by gender, year of birth and county of residence at index. For posts with age ≥ 90 years, controls were only matched by gender and year of birth due to the smaller available number of controls.\nThe selection of controls was performed without replacement.\nA control was allowed to become a case after the year of the index date for the case.\nA full set of controls (n = 2) was not found for all cases:\n\n\n\n\n\nPopulation\nNo controls\nPosts\nUnique patients\n\n\n\n\nCase SwedeHF\n0\n3849\n2156\n\n\nCase SwedeHF\n1\n17210\n7319\n\n\nCase SwedeHF\n2\n185575\n104900\n\n\nCase NPR\n0\n19057\n19057\n\n\nCase NPR\n1\n26433\n26433\n\n\nCase NPR\n2\n377386\n377386" + }, + { + "objectID": "population/index.html#inclusionexclusion-criteria", + "href": "population/index.html#inclusionexclusion-criteria", + "title": "Population", + "section": "Inclusion/exclusion criteria", + "text": "Inclusion/exclusion criteria\n\n\n\n\n\nCriteria\nCase SwedeHF\nCase NPR\nControl SwedeHF\nControl NPR\n\n\n\n\nNo of posts recieved\n216652\n471853\n405913\n802436\n\n\nExclude posts with duplicated index dates\n216029\n\n\n\n\n\nExclude posts with with index date < 2000-01-01\n216026\n437182\n405907\n799666\n\n\nExclude posts with with index date > 2021-12-31\n207290\n426074\n388928\n785550\n\n\nExclude posts < 18 years\n207277\n424752\n388903\n782942\n\n\nExclude posts that are not present in SCB register\n206875\n423401\n388903\n782942\n\n\nExclude posts with reused PINs\n206640\n423026\n388903\n782942\n\n\nExclude posts censored end fu < index\n206634\n422876\n388838\n782222\n\n\nExclude controls without cases\n206634\n422876\n388838\n782222\n\n\nExclude posts with end of follow-up <= index date (died in hospital)\n203425\n\n\n\n\n\nUnique patients\n112423" + }, + { + "objectID": "variabledescription/index.html", + "href": "variabledescription/index.html", + "title": "Variable description", + "section": "", + "text": "Download Variable Description" + } +] \ No newline at end of file diff --git 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NAME(){return"button"}toggle(){this._element.setAttribute("aria-pressed",this._element.classList.toggle("active"))}static jQueryInterface(t){return this.each((function(){const e=z.getOrCreateInstance(this);"toggle"===t&&e[t]()}))}}function q(t){return"true"===t||"false"!==t&&(t===Number(t).toString()?Number(t):""===t||"null"===t?null:t)}function F(t){return t.replace(/[A-Z]/g,(t=>`-${t.toLowerCase()}`))}j.on(document,"click.bs.button.data-api",$,(t=>{t.preventDefault();const e=t.target.closest($);z.getOrCreateInstance(e).toggle()})),g(z);const U={setDataAttribute(t,e,i){t.setAttribute(`data-bs-${F(e)}`,i)},removeDataAttribute(t,e){t.removeAttribute(`data-bs-${F(e)}`)},getDataAttributes(t){if(!t)return{};const e={};return Object.keys(t.dataset).filter((t=>t.startsWith("bs"))).forEach((i=>{let n=i.replace(/^bs/,"");n=n.charAt(0).toLowerCase()+n.slice(1,n.length),e[n]=q(t.dataset[i])})),e},getDataAttribute:(t,e)=>q(t.getAttribute(`data-bs-${F(e)}`)),offset(t){const 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t?t:{}},a(K,t,Y),t}_handleSwipe(){const t=Math.abs(this.touchDeltaX);if(t<=40)return;const e=t/this.touchDeltaX;this.touchDeltaX=0,e&&this._slide(e>0?J:Z)}_addEventListeners(){this._config.keyboard&&j.on(this._element,"keydown.bs.carousel",(t=>this._keydown(t))),"hover"===this._config.pause&&(j.on(this._element,"mouseenter.bs.carousel",(t=>this.pause(t))),j.on(this._element,"mouseleave.bs.carousel",(t=>this.cycle(t)))),this._config.touch&&this._touchSupported&&this._addTouchEventListeners()}_addTouchEventListeners(){const t=t=>this._pointerEvent&&("pen"===t.pointerType||"touch"===t.pointerType),e=e=>{t(e)?this.touchStartX=e.clientX:this._pointerEvent||(this.touchStartX=e.touches[0].clientX)},i=t=>{this.touchDeltaX=t.touches&&t.touches.length>1?0:t.touches[0].clientX-this.touchStartX},n=e=>{t(e)&&(this.touchDeltaX=e.clientX-this.touchStartX),this._handleSwipe(),"hover"===this._config.pause&&(this.pause(),this.touchTimeout&&clearTimeout(this.touchTimeout),this.touchTimeout=setTimeout((t=>this.cycle(t)),500+this._config.interval))};V.find(".carousel-item img",this._element).forEach((t=>{j.on(t,"dragstart.bs.carousel",(t=>t.preventDefault()))})),this._pointerEvent?(j.on(this._element,"pointerdown.bs.carousel",(t=>e(t))),j.on(this._element,"pointerup.bs.carousel",(t=>n(t))),this._element.classList.add("pointer-event")):(j.on(this._element,"touchstart.bs.carousel",(t=>e(t))),j.on(this._element,"touchmove.bs.carousel",(t=>i(t))),j.on(this._element,"touchend.bs.carousel",(t=>n(t))))}_keydown(t){if(/input|textarea/i.test(t.target.tagName))return;const e=tt[t.key];e&&(t.preventDefault(),this._slide(e))}_getItemIndex(t){return this._items=t&&t.parentNode?V.find(".carousel-item",t.parentNode):[],this._items.indexOf(t)}_getItemByOrder(t,e){const i=t===Q;return v(this._items,e,i,this._config.wrap)}_triggerSlideEvent(t,e){const i=this._getItemIndex(t),n=this._getItemIndex(V.findOne(nt,this._element));return 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n=this._getDimension();this._element.classList.remove(ct),this._element.classList.add(ht),this._element.style[n]=0,this._addAriaAndCollapsedClass(this._triggerArray,!0),this._isTransitioning=!0;const s=`scroll${n[0].toUpperCase()+n.slice(1)}`;this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(ht),this._element.classList.add(ct,lt),this._element.style[n]="",j.trigger(this._element,"shown.bs.collapse")}),this._element,!0),this._element.style[n]=`${this._element[s]}px`}hide(){if(this._isTransitioning||!this._isShown())return;if(j.trigger(this._element,"hide.bs.collapse").defaultPrevented)return;const t=this._getDimension();this._element.style[t]=`${this._element.getBoundingClientRect()[t]}px`,u(this._element),this._element.classList.add(ht),this._element.classList.remove(ct,lt);const e=this._triggerArray.length;for(let t=0;t{this._isTransitioning=!1,this._element.classList.remove(ht),this._element.classList.add(ct),j.trigger(this._element,"hidden.bs.collapse")}),this._element,!0)}_isShown(t=this._element){return t.classList.contains(lt)}_getConfig(t){return(t={...rt,...U.getDataAttributes(this._element),...t}).toggle=Boolean(t.toggle),t.parent=r(t.parent),a(ot,t,at),t}_getDimension(){return this._element.classList.contains("collapse-horizontal")?"width":"height"}_initializeChildren(){if(!this._config.parent)return;const t=V.find(ut,this._config.parent);V.find(ft,this._config.parent).filter((e=>!t.includes(e))).forEach((t=>{const e=n(t);e&&this._addAriaAndCollapsedClass([t],this._isShown(e))}))}_addAriaAndCollapsedClass(t,e){t.length&&t.forEach((t=>{e?t.classList.remove(dt):t.classList.add(dt),t.setAttribute("aria-expanded",e)}))}static jQueryInterface(t){return this.each((function(){const e={};"string"==typeof t&&/show|hide/.test(t)&&(e.toggle=!1);const 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e=t.ownerDocument;return e&&e.defaultView||window}return t}function $t(t){return t instanceof Wt(t).Element||t instanceof Element}function zt(t){return t instanceof Wt(t).HTMLElement||t instanceof HTMLElement}function qt(t){return"undefined"!=typeof ShadowRoot&&(t instanceof Wt(t).ShadowRoot||t instanceof ShadowRoot)}const Ft={name:"applyStyles",enabled:!0,phase:"write",fn:function(t){var e=t.state;Object.keys(e.elements).forEach((function(t){var i=e.styles[t]||{},n=e.attributes[t]||{},s=e.elements[t];zt(s)&&Rt(s)&&(Object.assign(s.style,i),Object.keys(n).forEach((function(t){var e=n[t];!1===e?s.removeAttribute(t):s.setAttribute(t,!0===e?"":e)})))}))},effect:function(t){var e=t.state,i={popper:{position:e.options.strategy,left:"0",top:"0",margin:"0"},arrow:{position:"absolute"},reference:{}};return Object.assign(e.elements.popper.style,i.popper),e.styles=i,e.elements.arrow&&Object.assign(e.elements.arrow.style,i.arrow),function(){Object.keys(e.elements).forEach((function(t){var 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Be={placement:"bottom",modifiers:[],strategy:"absolute"};function Re(){for(var t=arguments.length,e=new Array(t),i=0;ij.on(t,"mouseover",d))),this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add(Je),this._element.classList.add(Je),j.trigger(this._element,"shown.bs.dropdown",t)}hide(){if(c(this._element)||!this._isShown(this._menu))return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){j.trigger(this._element,"hide.bs.dropdown",t).defaultPrevented||("ontouchstart"in 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t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return"static"===this._config.display&&(t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=V.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter(l);i.length&&v(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(t&&(2===t.button||"keyup"===t.type&&"Tab"!==t.key))return;const e=V.find(ti);for(let i=0,n=e.length;ie+t)),this._setElementAttributes(di,"paddingRight",(e=>e+t)),this._setElementAttributes(ui,"marginRight",(e=>e-t))}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t)[e];t.style[e]=`${i(Number.parseFloat(s))}px`}))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,"paddingRight"),this._resetElementAttributes(di,"paddingRight"),this._resetElementAttributes(ui,"marginRight")}_saveInitialAttribute(t,e){const i=t.style[e];i&&U.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=U.getDataAttribute(t,e);void 0===i?t.style.removeProperty(e):(U.removeDataAttribute(t,e),t.style[e]=i)}))}_applyManipulationCallback(t,e){o(t)?e(t):V.find(t,this._element).forEach(e)}isOverflowing(){return this.getWidth()>0}}const pi={className:"modal-backdrop",isVisible:!0,isAnimated:!1,rootElement:"body",clickCallback:null},mi={className:"string",isVisible:"boolean",isAnimated:"boolean",rootElement:"(element|string)",clickCallback:"(function|null)"},gi="show",_i="mousedown.bs.backdrop";class bi{constructor(t){this._config=this._getConfig(t),this._isAppended=!1,this._element=null}show(t){this._config.isVisible?(this._append(),this._config.isAnimated&&u(this._getElement()),this._getElement().classList.add(gi),this._emulateAnimation((()=>{_(t)}))):_(t)}hide(t){this._config.isVisible?(this._getElement().classList.remove(gi),this._emulateAnimation((()=>{this.dispose(),_(t)}))):_(t)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_getConfig(t){return(t={...pi,..."object"==typeof t?t:{}}).rootElement=r(t.rootElement),a("backdrop",t,mi),t}_append(){this._isAppended||(this._config.rootElement.append(this._getElement()),j.on(this._getElement(),_i,(()=>{_(this._config.clickCallback)})),this._isAppended=!0)}dispose(){this._isAppended&&(j.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_emulateAnimation(t){b(t,this._getElement(),this._config.isAnimated)}}const vi={trapElement:null,autofocus:!0},yi={trapElement:"element",autofocus:"boolean"},wi=".bs.focustrap",Ei="backward";class Ai{constructor(t){this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}activate(){const{trapElement:t,autofocus:e}=this._config;this._isActive||(e&&t.focus(),j.off(document,wi),j.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),j.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,j.off(document,wi))}_handleFocusin(t){const{target:e}=t,{trapElement:i}=this._config;if(e===document||e===i||i.contains(e))return;const n=V.focusableChildren(i);0===n.length?i.focus():this._lastTabNavDirection===Ei?n[n.length-1].focus():n[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ei:"forward")}_getConfig(t){return t={...vi,..."object"==typeof t?t:{}},a("focustrap",t,yi),t}}const Ti="modal",Oi="Escape",Ci={backdrop:!0,keyboard:!0,focus:!0},ki={backdrop:"(boolean|string)",keyboard:"boolean",focus:"boolean"},Li="hidden.bs.modal",xi="show.bs.modal",Di="resize.bs.modal",Si="click.dismiss.bs.modal",Ni="keydown.dismiss.bs.modal",Ii="mousedown.dismiss.bs.modal",Pi="modal-open",ji="show",Mi="modal-static";class Hi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._dialog=V.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._ignoreBackdropClick=!1,this._isTransitioning=!1,this._scrollBar=new fi}static get Default(){return Ci}static get NAME(){return Ti}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||j.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isAnimated()&&(this._isTransitioning=!0),this._scrollBar.hide(),document.body.classList.add(Pi),this._adjustDialog(),this._setEscapeEvent(),this._setResizeEvent(),j.on(this._dialog,Ii,(()=>{j.one(this._element,"mouseup.dismiss.bs.modal",(t=>{t.target===this._element&&(this._ignoreBackdropClick=!0)}))})),this._showBackdrop((()=>this._showElement(t))))}hide(){if(!this._isShown||this._isTransitioning)return;if(j.trigger(this._element,"hide.bs.modal").defaultPrevented)return;this._isShown=!1;const t=this._isAnimated();t&&(this._isTransitioning=!0),this._setEscapeEvent(),this._setResizeEvent(),this._focustrap.deactivate(),this._element.classList.remove(ji),j.off(this._element,Si),j.off(this._dialog,Ii),this._queueCallback((()=>this._hideModal()),this._element,t)}dispose(){[window,this._dialog].forEach((t=>j.off(t,".bs.modal"))),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new bi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_getConfig(t){return t={...Ci,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Ti,t,ki),t}_showElement(t){const e=this._isAnimated(),i=V.findOne(".modal-body",this._dialog);this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0,i&&(i.scrollTop=0),e&&u(this._element),this._element.classList.add(ji),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,j.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,e)}_setEscapeEvent(){this._isShown?j.on(this._element,Ni,(t=>{this._config.keyboard&&t.key===Oi?(t.preventDefault(),this.hide()):this._config.keyboard||t.key!==Oi||this._triggerBackdropTransition()})):j.off(this._element,Ni)}_setResizeEvent(){this._isShown?j.on(window,Di,(()=>this._adjustDialog())):j.off(window,Di)}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(Pi),this._resetAdjustments(),this._scrollBar.reset(),j.trigger(this._element,Li)}))}_showBackdrop(t){j.on(this._element,Si,(t=>{this._ignoreBackdropClick?this._ignoreBackdropClick=!1:t.target===t.currentTarget&&(!0===this._config.backdrop?this.hide():"static"===this._config.backdrop&&this._triggerBackdropTransition())})),this._backdrop.show(t)}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(j.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const{classList:t,scrollHeight:e,style:i}=this._element,n=e>document.documentElement.clientHeight;!n&&"hidden"===i.overflowY||t.contains(Mi)||(n||(i.overflowY="hidden"),t.add(Mi),this._queueCallback((()=>{t.remove(Mi),n||this._queueCallback((()=>{i.overflowY=""}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;(!i&&t&&!m()||i&&!t&&m())&&(this._element.style.paddingLeft=`${e}px`),(i&&!t&&!m()||!i&&t&&m())&&(this._element.style.paddingRight=`${e}px`)}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}j.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),j.one(e,xi,(t=>{t.defaultPrevented||j.one(e,Li,(()=>{l(this)&&this.focus()}))}));const i=V.findOne(".modal.show");i&&Hi.getInstance(i).hide(),Hi.getOrCreateInstance(e).toggle(this)})),R(Hi),g(Hi);const Bi="offcanvas",Ri={backdrop:!0,keyboard:!0,scroll:!1},Wi={backdrop:"boolean",keyboard:"boolean",scroll:"boolean"},$i="show",zi=".offcanvas.show",qi="hidden.bs.offcanvas";class Fi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get NAME(){return Bi}static get Default(){return Ri}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||j.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._element.style.visibility="visible",this._backdrop.show(),this._config.scroll||(new fi).hide(),this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add($i),this._queueCallback((()=>{this._config.scroll||this._focustrap.activate(),j.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(j.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.remove($i),this._backdrop.hide(),this._queueCallback((()=>{this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._element.style.visibility="hidden",this._config.scroll||(new fi).reset(),j.trigger(this._element,qi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_getConfig(t){return t={...Ri,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Bi,t,Wi),t}_initializeBackDrop(){return new bi({className:"offcanvas-backdrop",isVisible:this._config.backdrop,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:()=>this.hide()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_addEventListeners(){j.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{this._config.keyboard&&"Escape"===t.key&&this.hide()}))}static jQueryInterface(t){return this.each((function(){const e=Fi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}j.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this))return;j.one(e,qi,(()=>{l(this)&&this.focus()}));const i=V.findOne(zi);i&&i!==e&&Fi.getInstance(i).hide(),Fi.getOrCreateInstance(e).toggle(this)})),j.on(window,"load.bs.offcanvas.data-api",(()=>V.find(zi).forEach((t=>Fi.getOrCreateInstance(t).show())))),R(Fi),g(Fi);const Ui=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Vi=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Ki=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Xi=(t,e)=>{const i=t.nodeName.toLowerCase();if(e.includes(i))return!Ui.has(i)||Boolean(Vi.test(t.nodeValue)||Ki.test(t.nodeValue));const n=e.filter((t=>t instanceof RegExp));for(let t=0,e=n.length;t{Xi(t,r)||i.removeAttribute(t.nodeName)}))}return n.body.innerHTML}const Qi="tooltip",Gi=new Set(["sanitize","allowList","sanitizeFn"]),Zi={animation:"boolean",template:"string",title:"(string|element|function)",trigger:"string",delay:"(number|object)",html:"boolean",selector:"(string|boolean)",placement:"(string|function)",offset:"(array|string|function)",container:"(string|element|boolean)",fallbackPlacements:"array",boundary:"(string|element)",customClass:"(string|function)",sanitize:"boolean",sanitizeFn:"(null|function)",allowList:"object",popperConfig:"(null|object|function)"},Ji={AUTO:"auto",TOP:"top",RIGHT:m()?"left":"right",BOTTOM:"bottom",LEFT:m()?"right":"left"},tn={animation:!0,template:'',trigger:"hover focus",title:"",delay:0,html:!1,selector:!1,placement:"top",offset:[0,0],container:!1,fallbackPlacements:["top","right","bottom","left"],boundary:"clippingParents",customClass:"",sanitize:!0,sanitizeFn:null,allowList:{"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},popperConfig:null},en={HIDE:"hide.bs.tooltip",HIDDEN:"hidden.bs.tooltip",SHOW:"show.bs.tooltip",SHOWN:"shown.bs.tooltip",INSERTED:"inserted.bs.tooltip",CLICK:"click.bs.tooltip",FOCUSIN:"focusin.bs.tooltip",FOCUSOUT:"focusout.bs.tooltip",MOUSEENTER:"mouseenter.bs.tooltip",MOUSELEAVE:"mouseleave.bs.tooltip"},nn="fade",sn="show",on="show",rn="out",an=".tooltip-inner",ln=".modal",cn="hide.bs.modal",hn="hover",dn="focus";class un extends B{constructor(t,e){if(void 0===Fe)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t),this._isEnabled=!0,this._timeout=0,this._hoverState="",this._activeTrigger={},this._popper=null,this._config=this._getConfig(e),this.tip=null,this._setListeners()}static get Default(){return tn}static get NAME(){return Qi}static get Event(){return en}static get DefaultType(){return Zi}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(t){if(this._isEnabled)if(t){const e=this._initializeOnDelegatedTarget(t);e._activeTrigger.click=!e._activeTrigger.click,e._isWithActiveTrigger()?e._enter(null,e):e._leave(null,e)}else{if(this.getTipElement().classList.contains(sn))return void this._leave(null,this);this._enter(null,this)}}dispose(){clearTimeout(this._timeout),j.off(this._element.closest(ln),cn,this._hideModalHandler),this.tip&&this.tip.remove(),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this.isWithContent()||!this._isEnabled)return;const t=j.trigger(this._element,this.constructor.Event.SHOW),e=h(this._element),i=null===e?this._element.ownerDocument.documentElement.contains(this._element):e.contains(this._element);if(t.defaultPrevented||!i)return;"tooltip"===this.constructor.NAME&&this.tip&&this.getTitle()!==this.tip.querySelector(an).innerHTML&&(this._disposePopper(),this.tip.remove(),this.tip=null);const n=this.getTipElement(),s=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME);n.setAttribute("id",s),this._element.setAttribute("aria-describedby",s),this._config.animation&&n.classList.add(nn);const o="function"==typeof this._config.placement?this._config.placement.call(this,n,this._element):this._config.placement,r=this._getAttachment(o);this._addAttachmentClass(r);const{container:a}=this._config;H.set(n,this.constructor.DATA_KEY,this),this._element.ownerDocument.documentElement.contains(this.tip)||(a.append(n),j.trigger(this._element,this.constructor.Event.INSERTED)),this._popper?this._popper.update():this._popper=qe(this._element,n,this._getPopperConfig(r)),n.classList.add(sn);const l=this._resolvePossibleFunction(this._config.customClass);l&&n.classList.add(...l.split(" ")),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>{j.on(t,"mouseover",d)}));const c=this.tip.classList.contains(nn);this._queueCallback((()=>{const t=this._hoverState;this._hoverState=null,j.trigger(this._element,this.constructor.Event.SHOWN),t===rn&&this._leave(null,this)}),this.tip,c)}hide(){if(!this._popper)return;const t=this.getTipElement();if(j.trigger(this._element,this.constructor.Event.HIDE).defaultPrevented)return;t.classList.remove(sn),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._activeTrigger.click=!1,this._activeTrigger.focus=!1,this._activeTrigger.hover=!1;const e=this.tip.classList.contains(nn);this._queueCallback((()=>{this._isWithActiveTrigger()||(this._hoverState!==on&&t.remove(),this._cleanTipClass(),this._element.removeAttribute("aria-describedby"),j.trigger(this._element,this.constructor.Event.HIDDEN),this._disposePopper())}),this.tip,e),this._hoverState=""}update(){null!==this._popper&&this._popper.update()}isWithContent(){return Boolean(this.getTitle())}getTipElement(){if(this.tip)return this.tip;const t=document.createElement("div");t.innerHTML=this._config.template;const e=t.children[0];return this.setContent(e),e.classList.remove(nn,sn),this.tip=e,this.tip}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),an)}_sanitizeAndSetContent(t,e,i){const n=V.findOne(i,t);e||!n?this.setElementContent(n,e):n.remove()}setElementContent(t,e){if(null!==t)return o(e)?(e=r(e),void(this._config.html?e.parentNode!==t&&(t.innerHTML="",t.append(e)):t.textContent=e.textContent)):void(this._config.html?(this._config.sanitize&&(e=Yi(e,this._config.allowList,this._config.sanitizeFn)),t.innerHTML=e):t.textContent=e)}getTitle(){const t=this._element.getAttribute("data-bs-original-title")||this._config.title;return this._resolvePossibleFunction(t)}updateAttachment(t){return"right"===t?"end":"left"===t?"start":t}_initializeOnDelegatedTarget(t,e){return e||this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return"function"==typeof t?t.call(this._element):t}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"onChange",enabled:!0,phase:"afterWrite",fn:t=>this._handlePopperPlacementChange(t)}],onFirstUpdate:t=>{t.options.placement!==t.placement&&this._handlePopperPlacementChange(t)}};return{...e,..."function"==typeof this._config.popperConfig?this._config.popperConfig(e):this._config.popperConfig}}_addAttachmentClass(t){this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(t)}`)}_getAttachment(t){return Ji[t.toUpperCase()]}_setListeners(){this._config.trigger.split(" ").forEach((t=>{if("click"===t)j.on(this._element,this.constructor.Event.CLICK,this._config.selector,(t=>this.toggle(t)));else if("manual"!==t){const e=t===hn?this.constructor.Event.MOUSEENTER:this.constructor.Event.FOCUSIN,i=t===hn?this.constructor.Event.MOUSELEAVE:this.constructor.Event.FOCUSOUT;j.on(this._element,e,this._config.selector,(t=>this._enter(t))),j.on(this._element,i,this._config.selector,(t=>this._leave(t)))}})),this._hideModalHandler=()=>{this._element&&this.hide()},j.on(this._element.closest(ln),cn,this._hideModalHandler),this._config.selector?this._config={...this._config,trigger:"manual",selector:""}:this._fixTitle()}_fixTitle(){const t=this._element.getAttribute("title"),e=typeof this._element.getAttribute("data-bs-original-title");(t||"string"!==e)&&(this._element.setAttribute("data-bs-original-title",t||""),!t||this._element.getAttribute("aria-label")||this._element.textContent||this._element.setAttribute("aria-label",t),this._element.setAttribute("title",""))}_enter(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusin"===t.type?dn:hn]=!0),e.getTipElement().classList.contains(sn)||e._hoverState===on?e._hoverState=on:(clearTimeout(e._timeout),e._hoverState=on,e._config.delay&&e._config.delay.show?e._timeout=setTimeout((()=>{e._hoverState===on&&e.show()}),e._config.delay.show):e.show())}_leave(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusout"===t.type?dn:hn]=e._element.contains(t.relatedTarget)),e._isWithActiveTrigger()||(clearTimeout(e._timeout),e._hoverState=rn,e._config.delay&&e._config.delay.hide?e._timeout=setTimeout((()=>{e._hoverState===rn&&e.hide()}),e._config.delay.hide):e.hide())}_isWithActiveTrigger(){for(const t in this._activeTrigger)if(this._activeTrigger[t])return!0;return!1}_getConfig(t){const e=U.getDataAttributes(this._element);return Object.keys(e).forEach((t=>{Gi.has(t)&&delete e[t]})),(t={...this.constructor.Default,...e,..."object"==typeof t&&t?t:{}}).container=!1===t.container?document.body:r(t.container),"number"==typeof t.delay&&(t.delay={show:t.delay,hide:t.delay}),"number"==typeof t.title&&(t.title=t.title.toString()),"number"==typeof t.content&&(t.content=t.content.toString()),a(Qi,t,this.constructor.DefaultType),t.sanitize&&(t.template=Yi(t.template,t.allowList,t.sanitizeFn)),t}_getDelegateConfig(){const t={};for(const e in this._config)this.constructor.Default[e]!==this._config[e]&&(t[e]=this._config[e]);return t}_cleanTipClass(){const t=this.getTipElement(),e=new RegExp(`(^|\\s)${this._getBasicClassPrefix()}\\S+`,"g"),i=t.getAttribute("class").match(e);null!==i&&i.length>0&&i.map((t=>t.trim())).forEach((e=>t.classList.remove(e)))}_getBasicClassPrefix(){return"bs-tooltip"}_handlePopperPlacementChange(t){const{state:e}=t;e&&(this.tip=e.elements.popper,this._cleanTipClass(),this._addAttachmentClass(this._getAttachment(e.placement)))}_disposePopper(){this._popper&&(this._popper.destroy(),this._popper=null)}static jQueryInterface(t){return this.each((function(){const e=un.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}g(un);const fn={...un.Default,placement:"right",offset:[0,8],trigger:"click",content:"",template:''},pn={...un.DefaultType,content:"(string|element|function)"},mn={HIDE:"hide.bs.popover",HIDDEN:"hidden.bs.popover",SHOW:"show.bs.popover",SHOWN:"shown.bs.popover",INSERTED:"inserted.bs.popover",CLICK:"click.bs.popover",FOCUSIN:"focusin.bs.popover",FOCUSOUT:"focusout.bs.popover",MOUSEENTER:"mouseenter.bs.popover",MOUSELEAVE:"mouseleave.bs.popover"};class gn extends un{static get Default(){return fn}static get NAME(){return"popover"}static get Event(){return mn}static get DefaultType(){return pn}isWithContent(){return this.getTitle()||this._getContent()}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),".popover-header"),this._sanitizeAndSetContent(t,this._getContent(),".popover-body")}_getContent(){return this._resolvePossibleFunction(this._config.content)}_getBasicClassPrefix(){return"bs-popover"}static jQueryInterface(t){return this.each((function(){const e=gn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}g(gn);const _n="scrollspy",bn={offset:10,method:"auto",target:""},vn={offset:"number",method:"string",target:"(string|element)"},yn="active",wn=".nav-link, .list-group-item, .dropdown-item",En="position";class An extends B{constructor(t,e){super(t),this._scrollElement="BODY"===this._element.tagName?window:this._element,this._config=this._getConfig(e),this._offsets=[],this._targets=[],this._activeTarget=null,this._scrollHeight=0,j.on(this._scrollElement,"scroll.bs.scrollspy",(()=>this._process())),this.refresh(),this._process()}static get Default(){return bn}static get NAME(){return _n}refresh(){const t=this._scrollElement===this._scrollElement.window?"offset":En,e="auto"===this._config.method?t:this._config.method,n=e===En?this._getScrollTop():0;this._offsets=[],this._targets=[],this._scrollHeight=this._getScrollHeight(),V.find(wn,this._config.target).map((t=>{const s=i(t),o=s?V.findOne(s):null;if(o){const t=o.getBoundingClientRect();if(t.width||t.height)return[U[e](o).top+n,s]}return null})).filter((t=>t)).sort(((t,e)=>t[0]-e[0])).forEach((t=>{this._offsets.push(t[0]),this._targets.push(t[1])}))}dispose(){j.off(this._scrollElement,".bs.scrollspy"),super.dispose()}_getConfig(t){return(t={...bn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}}).target=r(t.target)||document.documentElement,a(_n,t,vn),t}_getScrollTop(){return this._scrollElement===window?this._scrollElement.pageYOffset:this._scrollElement.scrollTop}_getScrollHeight(){return 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b/docs/site_libs/quarto-html/quarto-syntax-highlighting.css @@ -0,0 +1,203 @@ +/* quarto syntax highlight colors */ +:root { + --quarto-hl-ot-color: #003B4F; + --quarto-hl-at-color: #657422; + --quarto-hl-ss-color: #20794D; + --quarto-hl-an-color: #5E5E5E; + --quarto-hl-fu-color: #4758AB; + --quarto-hl-st-color: #20794D; + --quarto-hl-cf-color: #003B4F; + --quarto-hl-op-color: #5E5E5E; + --quarto-hl-er-color: #AD0000; + --quarto-hl-bn-color: #AD0000; + --quarto-hl-al-color: #AD0000; + --quarto-hl-va-color: #111111; + --quarto-hl-bu-color: inherit; + --quarto-hl-ex-color: inherit; + --quarto-hl-pp-color: #AD0000; + --quarto-hl-in-color: #5E5E5E; + --quarto-hl-vs-color: #20794D; + --quarto-hl-wa-color: #5E5E5E; + --quarto-hl-do-color: #5E5E5E; + --quarto-hl-im-color: #00769E; + --quarto-hl-ch-color: #20794D; + --quarto-hl-dt-color: #AD0000; + --quarto-hl-fl-color: #AD0000; + --quarto-hl-co-color: #5E5E5E; + --quarto-hl-cv-color: #5E5E5E; + --quarto-hl-cn-color: #8f5902; + --quarto-hl-sc-color: #5E5E5E; + --quarto-hl-dv-color: #AD0000; + --quarto-hl-kw-color: #003B4F; +} + +/* other quarto variables */ +:root { + --quarto-font-monospace: SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace; +} + +pre > code.sourceCode > span { + color: #003B4F; +} + +code span { + color: #003B4F; +} + +code.sourceCode > span { + color: #003B4F; +} + +div.sourceCode, +div.sourceCode pre.sourceCode { + color: #003B4F; +} + +code span.ot { + color: #003B4F; + font-style: inherit; +} + +code span.at { + color: #657422; + font-style: inherit; +} + +code span.ss { + color: #20794D; + font-style: inherit; +} + +code span.an { + color: #5E5E5E; + font-style: inherit; +} + +code span.fu { + color: #4758AB; + font-style: inherit; +} + +code span.st { + color: #20794D; + font-style: inherit; +} + +code span.cf { + color: #003B4F; + font-style: inherit; +} + +code span.op { + color: #5E5E5E; + font-style: inherit; +} + +code span.er { + color: #AD0000; + font-style: inherit; +} + +code span.bn { + color: #AD0000; + font-style: inherit; +} + +code span.al { + color: #AD0000; + font-style: inherit; +} + +code span.va { + color: #111111; + font-style: inherit; +} + +code span.bu { + font-style: inherit; +} + +code span.ex { + font-style: inherit; +} + +code span.pp { + color: #AD0000; + font-style: inherit; +} + +code span.in { + color: #5E5E5E; + font-style: inherit; +} + +code span.vs { + color: #20794D; + font-style: inherit; +} + +code span.wa { + color: #5E5E5E; + font-style: italic; +} + +code span.do { + color: #5E5E5E; + font-style: italic; +} + +code span.im { + color: #00769E; + font-style: inherit; +} + +code span.ch { + color: #20794D; + font-style: inherit; +} + +code span.dt { + color: #AD0000; + font-style: inherit; +} + +code span.fl { + color: #AD0000; + font-style: inherit; +} + +code span.co { + color: #5E5E5E; + font-style: inherit; +} + +code span.cv { + color: #5E5E5E; + font-style: italic; +} + +code span.cn { + color: #8f5902; + font-style: inherit; +} + +code span.sc { + color: #5E5E5E; + font-style: inherit; +} + +code span.dv { + color: #AD0000; + font-style: inherit; +} + +code span.kw { + color: #003B4F; + font-style: inherit; +} + +.prevent-inlining { + content: " { + // Find any conflicting margin elements and add margins to the + // top to prevent overlap + const marginChildren = window.document.querySelectorAll( + ".column-margin.column-container > * " + ); + + let lastBottom = 0; + for (const marginChild of marginChildren) { + if (marginChild.offsetParent !== null) { + // clear the top margin so we recompute it + marginChild.style.marginTop = null; + const top = marginChild.getBoundingClientRect().top + window.scrollY; + console.log({ + childtop: marginChild.getBoundingClientRect().top, + scroll: window.scrollY, + top, + lastBottom, + }); + if (top < lastBottom) { + const margin = lastBottom - top; + marginChild.style.marginTop = `${margin}px`; + } + const styles = window.getComputedStyle(marginChild); + const marginTop = parseFloat(styles["marginTop"]); + + console.log({ + top, + height: marginChild.getBoundingClientRect().height, + marginTop, + total: top + marginChild.getBoundingClientRect().height + marginTop, + }); + lastBottom = top + marginChild.getBoundingClientRect().height + marginTop; + } + } +}; + +window.document.addEventListener("DOMContentLoaded", function (_event) { + // Recompute the position of margin elements anytime the body size changes + if (window.ResizeObserver) { + const resizeObserver = new window.ResizeObserver( + throttle(layoutMarginEls, 50) + ); + resizeObserver.observe(window.document.body); + } + + const tocEl = window.document.querySelector('nav.toc-active[role="doc-toc"]'); + const sidebarEl = window.document.getElementById("quarto-sidebar"); + const leftTocEl = window.document.getElementById("quarto-sidebar-toc-left"); + const marginSidebarEl = window.document.getElementById( + "quarto-margin-sidebar" + ); + // function to determine whether the element has a previous sibling that is active + const prevSiblingIsActiveLink = (el) => { + const sibling = el.previousElementSibling; + if (sibling && sibling.tagName === "A") { + return sibling.classList.contains("active"); + } else { + return false; + } + }; + + // fire slideEnter for bootstrap tab activations (for htmlwidget resize behavior) + function fireSlideEnter(e) { + const event = window.document.createEvent("Event"); + event.initEvent("slideenter", true, true); + window.document.dispatchEvent(event); + } + const tabs = window.document.querySelectorAll('a[data-bs-toggle="tab"]'); + tabs.forEach((tab) => { + tab.addEventListener("shown.bs.tab", fireSlideEnter); + }); + + // fire slideEnter for tabby tab activations (for htmlwidget resize behavior) + document.addEventListener("tabby", fireSlideEnter, false); + + // Track scrolling and mark TOC links as active + // get table of contents and sidebar (bail if we don't have at least one) + const tocLinks = tocEl + ? [...tocEl.querySelectorAll("a[data-scroll-target]")] + : []; + const makeActive = (link) => tocLinks[link].classList.add("active"); + const removeActive = (link) => tocLinks[link].classList.remove("active"); + const removeAllActive = () => + [...Array(tocLinks.length).keys()].forEach((link) => removeActive(link)); + + // activate the anchor for a section associated with this TOC entry + tocLinks.forEach((link) => { + link.addEventListener("click", () => { + if (link.href.indexOf("#") !== -1) { + const anchor = link.href.split("#")[1]; + const heading = window.document.querySelector( + `[data-anchor-id=${anchor}]` + ); + if (heading) { + // Add the class + heading.classList.add("reveal-anchorjs-link"); + + // function to show the anchor + const handleMouseout = () => { + heading.classList.remove("reveal-anchorjs-link"); + heading.removeEventListener("mouseout", handleMouseout); + }; + + // add a function to clear the anchor when the user mouses out of it + heading.addEventListener("mouseout", handleMouseout); + } + } + }); + }); + + const sections = tocLinks.map((link) => { + const target = link.getAttribute("data-scroll-target"); + if (target.startsWith("#")) { + return window.document.getElementById(decodeURI(`${target.slice(1)}`)); + } else { + return window.document.querySelector(decodeURI(`${target}`)); + } + }); + + const sectionMargin = 200; + let currentActive = 0; + // track whether we've initialized state the first time + let init = false; + + const updateActiveLink = () => { + // The index from bottom to top (e.g. reversed list) + let sectionIndex = -1; + if ( + window.innerHeight + window.pageYOffset >= + window.document.body.offsetHeight + ) { + sectionIndex = 0; + } else { + sectionIndex = [...sections].reverse().findIndex((section) => { + if (section) { + return window.pageYOffset >= section.offsetTop - sectionMargin; + } else { + return false; + } + }); + } + if (sectionIndex > -1) { + const current = sections.length - sectionIndex - 1; + if (current !== currentActive) { + removeAllActive(); + currentActive = current; + makeActive(current); + if (init) { + window.dispatchEvent(sectionChanged); + } + init = true; + } + } + }; + + const inHiddenRegion = (top, bottom, hiddenRegions) => { + for (const region of hiddenRegions) { + if (top <= region.bottom && bottom >= region.top) { + return true; + } + } + return false; + }; + + const categorySelector = "header.quarto-title-block .quarto-category"; + const activateCategories = (href) => { + // Find any categories + // Surround them with a link pointing back to: + // #category=Authoring + try { + const categoryEls = window.document.querySelectorAll(categorySelector); + for (const categoryEl of categoryEls) { + const categoryText = categoryEl.textContent; + if (categoryText) { + const link = `${href}#category=${encodeURIComponent(categoryText)}`; + const linkEl = window.document.createElement("a"); + linkEl.setAttribute("href", link); + for (const child of categoryEl.childNodes) { + linkEl.append(child); + } + categoryEl.appendChild(linkEl); + } + } + } catch { + // Ignore errors + } + }; + function hasTitleCategories() { + return window.document.querySelector(categorySelector) !== null; + } + + function offsetRelativeUrl(url) { + const offset = getMeta("quarto:offset"); + return offset ? offset + url : url; + } + + function offsetAbsoluteUrl(url) { + const offset = getMeta("quarto:offset"); + const baseUrl = new URL(offset, window.location); + + const projRelativeUrl = url.replace(baseUrl, ""); + if (projRelativeUrl.startsWith("/")) { + return projRelativeUrl; + } else { + return "/" + projRelativeUrl; + } + } + + // read a meta tag value + function getMeta(metaName) { + const metas = window.document.getElementsByTagName("meta"); + for (let i = 0; i < metas.length; i++) { + if (metas[i].getAttribute("name") === metaName) { + return metas[i].getAttribute("content"); + } + } + return ""; + } + + async function findAndActivateCategories() { + const currentPagePath = offsetAbsoluteUrl(window.location.href); + const response = await fetch(offsetRelativeUrl("listings.json")); + if (response.status == 200) { + return response.json().then(function (listingPaths) { + const listingHrefs = []; + for (const listingPath of listingPaths) { + const pathWithoutLeadingSlash = listingPath.listing.substring(1); + for (const item of listingPath.items) { + if ( + item === currentPagePath || + item === currentPagePath + "index.html" + ) { + // Resolve this path against the offset to be sure + // we already are using the correct path to the listing + // (this adjusts the listing urls to be rooted against + // whatever root the page is actually running against) + const relative = offsetRelativeUrl(pathWithoutLeadingSlash); + const baseUrl = window.location; + const resolvedPath = new URL(relative, baseUrl); + listingHrefs.push(resolvedPath.pathname); + break; + } + } + } + + // Look up the tree for a nearby linting and use that if we find one + const nearestListing = findNearestParentListing( + offsetAbsoluteUrl(window.location.pathname), + listingHrefs + ); + if (nearestListing) { + activateCategories(nearestListing); + } else { + // See if the referrer is a listing page for this item + const referredRelativePath = offsetAbsoluteUrl(document.referrer); + const referrerListing = listingHrefs.find((listingHref) => { + const isListingReferrer = + listingHref === referredRelativePath || + listingHref === referredRelativePath + "index.html"; + return isListingReferrer; + }); + + if (referrerListing) { + // Try to use the referrer if possible + activateCategories(referrerListing); + } else if (listingHrefs.length > 0) { + // Otherwise, just fall back to the first listing + activateCategories(listingHrefs[0]); + } + } + }); + } + } + if (hasTitleCategories()) { + findAndActivateCategories(); + } + + const findNearestParentListing = (href, listingHrefs) => { + if (!href || !listingHrefs) { + return undefined; + } + // Look up the tree for a nearby linting and use that if we find one + const relativeParts = href.substring(1).split("/"); + while (relativeParts.length > 0) { + const path = relativeParts.join("/"); + for (const listingHref of listingHrefs) { + if (listingHref.startsWith(path)) { + return listingHref; + } + } + relativeParts.pop(); + } + + return undefined; + }; + + const manageSidebarVisiblity = (el, placeholderDescriptor) => { + let isVisible = true; + let elRect; + + return (hiddenRegions) => { + if (el === null) { + return; + } + + // Find the last element of the TOC + const lastChildEl = el.lastElementChild; + + if (lastChildEl) { + // Converts the sidebar to a menu + const convertToMenu = () => { + for (const child of el.children) { + child.style.opacity = 0; + child.style.overflow = "hidden"; + } + + nexttick(() => { + const toggleContainer = window.document.createElement("div"); + toggleContainer.style.width = "100%"; + toggleContainer.classList.add("zindex-over-content"); + toggleContainer.classList.add("quarto-sidebar-toggle"); + toggleContainer.classList.add("headroom-target"); // Marks this to be managed by headeroom + toggleContainer.id = placeholderDescriptor.id; + toggleContainer.style.position = "fixed"; + + const toggleIcon = window.document.createElement("i"); + toggleIcon.classList.add("quarto-sidebar-toggle-icon"); + toggleIcon.classList.add("bi"); + toggleIcon.classList.add("bi-caret-down-fill"); + + const toggleTitle = window.document.createElement("div"); + const titleEl = window.document.body.querySelector( + placeholderDescriptor.titleSelector + ); + if (titleEl) { + toggleTitle.append( + titleEl.textContent || titleEl.innerText, + toggleIcon + ); + } + toggleTitle.classList.add("zindex-over-content"); + toggleTitle.classList.add("quarto-sidebar-toggle-title"); + toggleContainer.append(toggleTitle); + + const toggleContents = window.document.createElement("div"); + toggleContents.classList = el.classList; + toggleContents.classList.add("zindex-over-content"); + toggleContents.classList.add("quarto-sidebar-toggle-contents"); + for (const child of el.children) { + if (child.id === "toc-title") { + continue; + } + + const clone = child.cloneNode(true); + clone.style.opacity = 1; + clone.style.display = null; + toggleContents.append(clone); + } + toggleContents.style.height = "0px"; + const positionToggle = () => { + // position the element (top left of parent, same width as parent) + if (!elRect) { + elRect = el.getBoundingClientRect(); + } + toggleContainer.style.left = `${elRect.left}px`; + toggleContainer.style.top = `${elRect.top}px`; + toggleContainer.style.width = `${elRect.width}px`; + }; + positionToggle(); + + toggleContainer.append(toggleContents); + el.parentElement.prepend(toggleContainer); + + // Process clicks + let tocShowing = false; + // Allow the caller to control whether this is dismissed + // when it is clicked (e.g. sidebar navigation supports + // opening and closing the nav tree, so don't dismiss on click) + const clickEl = placeholderDescriptor.dismissOnClick + ? toggleContainer + : toggleTitle; + + const closeToggle = () => { + if (tocShowing) { + toggleContainer.classList.remove("expanded"); + toggleContents.style.height = "0px"; + tocShowing = false; + } + }; + + // Get rid of any expanded toggle if the user scrolls + window.document.addEventListener( + "scroll", + throttle(() => { + closeToggle(); + }, 50) + ); + + // Handle positioning of the toggle + window.addEventListener( + "resize", + throttle(() => { + elRect = undefined; + positionToggle(); + }, 50) + ); + + window.addEventListener("quarto-hrChanged", () => { + elRect = undefined; + }); + + // Process the click + clickEl.onclick = () => { + if (!tocShowing) { + toggleContainer.classList.add("expanded"); + toggleContents.style.height = null; + tocShowing = true; + } else { + closeToggle(); + } + }; + }); + }; + + // Converts a sidebar from a menu back to a sidebar + const convertToSidebar = () => { + for (const child of el.children) { + child.style.opacity = 1; + child.style.overflow = null; + } + + const placeholderEl = window.document.getElementById( + placeholderDescriptor.id + ); + if (placeholderEl) { + placeholderEl.remove(); + } + + el.classList.remove("rollup"); + }; + + if (isReaderMode()) { + convertToMenu(); + isVisible = false; + } else { + // Find the top and bottom o the element that is being managed + const elTop = el.offsetTop; + const elBottom = + elTop + lastChildEl.offsetTop + lastChildEl.offsetHeight; + + if (!isVisible) { + // If the element is current not visible reveal if there are + // no conflicts with overlay regions + if (!inHiddenRegion(elTop, elBottom, hiddenRegions)) { + convertToSidebar(); + isVisible = true; + } + } else { + // If the element is visible, hide it if it conflicts with overlay regions + // and insert a placeholder toggle (or if we're in reader mode) + if (inHiddenRegion(elTop, elBottom, hiddenRegions)) { + convertToMenu(); + isVisible = false; + } + } + } + } + }; + }; + + const tabEls = document.querySelectorAll('a[data-bs-toggle="tab"]'); + for (const tabEl of tabEls) { + const id = tabEl.getAttribute("data-bs-target"); + if (id) { + const columnEl = document.querySelector( + `${id} .column-margin, .tabset-margin-content` + ); + if (columnEl) + tabEl.addEventListener("shown.bs.tab", function (event) { + const el = event.srcElement; + if (el) { + const visibleCls = `${el.id}-margin-content`; + // walk up until we find a parent tabset + let panelTabsetEl = el.parentElement; + while (panelTabsetEl) { + if (panelTabsetEl.classList.contains("panel-tabset")) { + break; + } + panelTabsetEl = panelTabsetEl.parentElement; + } + + if (panelTabsetEl) { + const prevSib = panelTabsetEl.previousElementSibling; + if ( + prevSib && + prevSib.classList.contains("tabset-margin-container") + ) { + const childNodes = prevSib.querySelectorAll( + ".tabset-margin-content" + ); + for (const childEl of childNodes) { + if (childEl.classList.contains(visibleCls)) { + childEl.classList.remove("collapse"); + } else { + childEl.classList.add("collapse"); + } + } + } + } + } + + layoutMarginEls(); + }); + } + } + + // Manage the visibility of the toc and the sidebar + const marginScrollVisibility = manageSidebarVisiblity(marginSidebarEl, { + id: "quarto-toc-toggle", + titleSelector: "#toc-title", + dismissOnClick: true, + }); + const sidebarScrollVisiblity = manageSidebarVisiblity(sidebarEl, { + id: "quarto-sidebarnav-toggle", + titleSelector: ".title", + dismissOnClick: false, + }); + let tocLeftScrollVisibility; + if (leftTocEl) { + tocLeftScrollVisibility = manageSidebarVisiblity(leftTocEl, { + id: "quarto-lefttoc-toggle", + titleSelector: "#toc-title", + dismissOnClick: true, + }); + } + + // Find the first element that uses formatting in special columns + const conflictingEls = window.document.body.querySelectorAll( + '[class^="column-"], [class*=" column-"], aside, [class*="margin-caption"], [class*=" margin-caption"], [class*="margin-ref"], [class*=" margin-ref"]' + ); + + // Filter all the possibly conflicting elements into ones + // the do conflict on the left or ride side + const arrConflictingEls = Array.from(conflictingEls); + const leftSideConflictEls = arrConflictingEls.filter((el) => { + if (el.tagName === "ASIDE") { + return false; + } + return Array.from(el.classList).find((className) => { + return ( + className !== "column-body" && + className.startsWith("column-") && + !className.endsWith("right") && + !className.endsWith("container") && + className !== "column-margin" + ); + }); + }); + const rightSideConflictEls = arrConflictingEls.filter((el) => { + if (el.tagName === "ASIDE") { + return true; + } + + const hasMarginCaption = Array.from(el.classList).find((className) => { + return className == "margin-caption"; + }); + if (hasMarginCaption) { + return true; + } + + return Array.from(el.classList).find((className) => { + return ( + className !== "column-body" && + !className.endsWith("container") && + className.startsWith("column-") && + !className.endsWith("left") + ); + }); + }); + + const kOverlapPaddingSize = 10; + function toRegions(els) { + return els.map((el) => { + const boundRect = el.getBoundingClientRect(); + const top = + boundRect.top + + document.documentElement.scrollTop - + kOverlapPaddingSize; + return { + top, + bottom: top + el.scrollHeight + 2 * kOverlapPaddingSize, + }; + }); + } + + let hasObserved = false; + const visibleItemObserver = (els) => { + let visibleElements = [...els]; + const intersectionObserver = new IntersectionObserver( + (entries, _observer) => { + entries.forEach((entry) => { + if (entry.isIntersecting) { + if (visibleElements.indexOf(entry.target) === -1) { + visibleElements.push(entry.target); + } + } else { + visibleElements = visibleElements.filter((visibleEntry) => { + return visibleEntry !== entry; + }); + } + }); + + if (!hasObserved) { + hideOverlappedSidebars(); + } + hasObserved = true; + }, + {} + ); + els.forEach((el) => { + intersectionObserver.observe(el); + }); + + return { + getVisibleEntries: () => { + return visibleElements; + }, + }; + }; + + const rightElementObserver = visibleItemObserver(rightSideConflictEls); + const leftElementObserver = visibleItemObserver(leftSideConflictEls); + + const hideOverlappedSidebars = () => { + marginScrollVisibility(toRegions(rightElementObserver.getVisibleEntries())); + sidebarScrollVisiblity(toRegions(leftElementObserver.getVisibleEntries())); + if (tocLeftScrollVisibility) { + tocLeftScrollVisibility( + toRegions(leftElementObserver.getVisibleEntries()) + ); + } + }; + + window.quartoToggleReader = () => { + // Applies a slow class (or removes it) + // to update the transition speed + const slowTransition = (slow) => { + const manageTransition = (id, slow) => { + const el = document.getElementById(id); + if (el) { + if (slow) { + el.classList.add("slow"); + } else { + el.classList.remove("slow"); + } + } + }; + + manageTransition("TOC", slow); + manageTransition("quarto-sidebar", slow); + }; + const readerMode = !isReaderMode(); + setReaderModeValue(readerMode); + + // If we're entering reader mode, slow the transition + if (readerMode) { + slowTransition(readerMode); + } + highlightReaderToggle(readerMode); + hideOverlappedSidebars(); + + // If we're exiting reader mode, restore the non-slow transition + if (!readerMode) { + slowTransition(!readerMode); + } + }; + + const highlightReaderToggle = (readerMode) => { + const els = document.querySelectorAll(".quarto-reader-toggle"); + if (els) { + els.forEach((el) => { + if (readerMode) { + el.classList.add("reader"); + } else { + el.classList.remove("reader"); + } + }); + } + }; + + const setReaderModeValue = (val) => { + if (window.location.protocol !== "file:") { + window.localStorage.setItem("quarto-reader-mode", val); + } else { + localReaderMode = val; + } + }; + + const isReaderMode = () => { + if (window.location.protocol !== "file:") { + return window.localStorage.getItem("quarto-reader-mode") === "true"; + } else { + return localReaderMode; + } + }; + let localReaderMode = null; + + const tocOpenDepthStr = tocEl?.getAttribute("data-toc-expanded"); + const tocOpenDepth = tocOpenDepthStr ? Number(tocOpenDepthStr) : 1; + + // Walk the TOC and collapse/expand nodes + // Nodes are expanded if: + // - they are top level + // - they have children that are 'active' links + // - they are directly below an link that is 'active' + const walk = (el, depth) => { + // Tick depth when we enter a UL + if (el.tagName === "UL") { + depth = depth + 1; + } + + // It this is active link + let isActiveNode = false; + if (el.tagName === "A" && el.classList.contains("active")) { + isActiveNode = true; + } + + // See if there is an active child to this element + let hasActiveChild = false; + for (child of el.children) { + hasActiveChild = walk(child, depth) || hasActiveChild; + } + + // Process the collapse state if this is an UL + if (el.tagName === "UL") { + if (tocOpenDepth === -1 && depth > 1) { + el.classList.add("collapse"); + } else if ( + depth <= tocOpenDepth || + hasActiveChild || + prevSiblingIsActiveLink(el) + ) { + el.classList.remove("collapse"); + } else { + el.classList.add("collapse"); + } + + // untick depth when we leave a UL + depth = depth - 1; + } + return hasActiveChild || isActiveNode; + }; + + // walk the TOC and expand / collapse any items that should be shown + + if (tocEl) { + walk(tocEl, 0); + updateActiveLink(); + } + + // Throttle the scroll event and walk peridiocally + window.document.addEventListener( + "scroll", + throttle(() => { + if (tocEl) { + updateActiveLink(); + walk(tocEl, 0); + } + if (!isReaderMode()) { + hideOverlappedSidebars(); + } + }, 5) + ); + window.addEventListener( + "resize", + throttle(() => { + if (!isReaderMode()) { + hideOverlappedSidebars(); + } + }, 10) + ); + hideOverlappedSidebars(); + highlightReaderToggle(isReaderMode()); +}); + +// grouped tabsets +window.addEventListener("pageshow", (_event) => { + function getTabSettings() { + const data = localStorage.getItem("quarto-persistent-tabsets-data"); + if (!data) { + localStorage.setItem("quarto-persistent-tabsets-data", "{}"); + return {}; + } + if (data) { + return JSON.parse(data); + } + } + + function setTabSettings(data) { + localStorage.setItem( + "quarto-persistent-tabsets-data", + JSON.stringify(data) + ); + } + + function setTabState(groupName, groupValue) { + const data = getTabSettings(); + data[groupName] = groupValue; + setTabSettings(data); + } + + function toggleTab(tab, active) { + const tabPanelId = tab.getAttribute("aria-controls"); + const tabPanel = document.getElementById(tabPanelId); + if (active) { + tab.classList.add("active"); + tabPanel.classList.add("active"); + } else { + tab.classList.remove("active"); + tabPanel.classList.remove("active"); + } + } + + function toggleAll(selectedGroup, selectorsToSync) { + for (const [thisGroup, tabs] of Object.entries(selectorsToSync)) { + const active = selectedGroup === thisGroup; + for (const tab of tabs) { + toggleTab(tab, active); + } + } + } + + function findSelectorsToSyncByLanguage() { + const result = {}; + const tabs = Array.from( + document.querySelectorAll(`div[data-group] a[id^='tabset-']`) + ); + for (const item of tabs) { + const div = item.parentElement.parentElement.parentElement; + const group = div.getAttribute("data-group"); + if (!result[group]) { + result[group] = {}; + } + const selectorsToSync = result[group]; + const value = item.innerHTML; + if (!selectorsToSync[value]) { + selectorsToSync[value] = []; + } + selectorsToSync[value].push(item); + } + return result; + } + + function setupSelectorSync() { + const selectorsToSync = findSelectorsToSyncByLanguage(); + Object.entries(selectorsToSync).forEach(([group, tabSetsByValue]) => { + Object.entries(tabSetsByValue).forEach(([value, items]) => { + items.forEach((item) => { + item.addEventListener("click", (_event) => { + setTabState(group, value); + toggleAll(value, selectorsToSync[group]); + }); + }); + }); + }); + return selectorsToSync; + } + + const selectorsToSync = setupSelectorSync(); + for (const [group, selectedName] of Object.entries(getTabSettings())) { + const selectors = selectorsToSync[group]; + // it's possible that stale state gives us empty selections, so we explicitly check here. + if (selectors) { + toggleAll(selectedName, selectors); + } + } +}); + +function throttle(func, wait) { + let waiting = false; + return function () { + if (!waiting) { + func.apply(this, arguments); + waiting = true; + setTimeout(function () { + waiting = false; + }, wait); + } + }; +} + +function nexttick(func) { + return setTimeout(func, 0); +} diff --git a/docs/site_libs/quarto-html/tippy.css b/docs/site_libs/quarto-html/tippy.css new file mode 100644 index 0000000..e6ae635 --- /dev/null +++ b/docs/site_libs/quarto-html/tippy.css @@ -0,0 +1 @@ +.tippy-box[data-animation=fade][data-state=hidden]{opacity:0}[data-tippy-root]{max-width:calc(100vw - 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b/docs/site_libs/quarto-nav/quarto-nav.js new file mode 100644 index 0000000..3b21201 --- /dev/null +++ b/docs/site_libs/quarto-nav/quarto-nav.js @@ -0,0 +1,277 @@ +const headroomChanged = new CustomEvent("quarto-hrChanged", { + detail: {}, + bubbles: true, + cancelable: false, + composed: false, +}); + +window.document.addEventListener("DOMContentLoaded", function () { + let init = false; + + // Manage the back to top button, if one is present. + let lastScrollTop = window.pageYOffset || document.documentElement.scrollTop; + const scrollDownBuffer = 5; + const scrollUpBuffer = 35; + const btn = document.getElementById("quarto-back-to-top"); + const hideBackToTop = () => { + btn.style.display = "none"; + }; + const showBackToTop = () => { + btn.style.display = "inline-block"; + }; + if (btn) { + window.document.addEventListener( + "scroll", + function () { + const currentScrollTop = + window.pageYOffset || document.documentElement.scrollTop; + + // Shows and hides the button 'intelligently' as the user scrolls + if (currentScrollTop - scrollDownBuffer > lastScrollTop) { + hideBackToTop(); + lastScrollTop = currentScrollTop <= 0 ? 0 : currentScrollTop; + } else if (currentScrollTop < lastScrollTop - scrollUpBuffer) { + showBackToTop(); + lastScrollTop = currentScrollTop <= 0 ? 0 : currentScrollTop; + } + + // Show the button at the bottom, hides it at the top + if (currentScrollTop <= 0) { + hideBackToTop(); + } else if ( + window.innerHeight + currentScrollTop >= + document.body.offsetHeight + ) { + showBackToTop(); + } + }, + false + ); + } + + function throttle(func, wait) { + var timeout; + return function () { + const context = this; + const args = arguments; + const later = function () { + clearTimeout(timeout); + timeout = null; + func.apply(context, args); + }; + + if (!timeout) { + timeout = setTimeout(later, wait); + } + }; + } + + function headerOffset() { + // Set an offset if there is are fixed top navbar + const headerEl = window.document.querySelector("header.fixed-top"); + if (headerEl) { + return headerEl.clientHeight; + } else { + return 0; + } + } + + function footerOffset() { + const footerEl = window.document.querySelector("footer.footer"); + if (footerEl) { + return footerEl.clientHeight; + } else { + return 0; + } + } + + function updateDocumentOffsetWithoutAnimation() { + updateDocumentOffset(false); + } + + function updateDocumentOffset(animated) { + // set body offset + const topOffset = headerOffset(); + const bodyOffset = topOffset + footerOffset(); + const bodyEl = window.document.body; + bodyEl.setAttribute("data-bs-offset", topOffset); + bodyEl.style.paddingTop = topOffset + "px"; + + // deal with sidebar offsets + const sidebars = window.document.querySelectorAll( + ".sidebar, .headroom-target" + ); + sidebars.forEach((sidebar) => { + if (!animated) { + sidebar.classList.add("notransition"); + // Remove the no transition class after the animation has time to complete + setTimeout(function () { + sidebar.classList.remove("notransition"); + }, 201); + } + + if (window.Headroom && sidebar.classList.contains("sidebar-unpinned")) { + sidebar.style.top = "0"; + sidebar.style.maxHeight = "100vh"; + } else { + sidebar.style.top = topOffset + "px"; + sidebar.style.maxHeight = "calc(100vh - " + topOffset + "px)"; + } + }); + + // allow space for footer + const mainContainer = window.document.querySelector(".quarto-container"); + if (mainContainer) { + mainContainer.style.minHeight = "calc(100vh - " + bodyOffset + "px)"; + } + + // link offset + let linkStyle = window.document.querySelector("#quarto-target-style"); + if (!linkStyle) { + linkStyle = window.document.createElement("style"); + linkStyle.setAttribute("id", "quarto-target-style"); + window.document.head.appendChild(linkStyle); + } + while (linkStyle.firstChild) { + linkStyle.removeChild(linkStyle.firstChild); + } + if (topOffset > 0) { + linkStyle.appendChild( + window.document.createTextNode(` + section:target::before { + content: ""; + display: block; + height: ${topOffset}px; + margin: -${topOffset}px 0 0; + }`) + ); + } + if (init) { + window.dispatchEvent(headroomChanged); + } + init = true; + } + + // initialize headroom + var header = window.document.querySelector("#quarto-header"); + if (header && window.Headroom) { + const headroom = new window.Headroom(header, { + tolerance: 5, + onPin: function () { + const sidebars = window.document.querySelectorAll( + ".sidebar, .headroom-target" + ); + sidebars.forEach((sidebar) => { + sidebar.classList.remove("sidebar-unpinned"); + }); + updateDocumentOffset(); + }, + onUnpin: function () { + const sidebars = window.document.querySelectorAll( + ".sidebar, .headroom-target" + ); + sidebars.forEach((sidebar) => { + sidebar.classList.add("sidebar-unpinned"); + }); + updateDocumentOffset(); + }, + }); + headroom.init(); + + let frozen = false; + window.quartoToggleHeadroom = function () { + if (frozen) { + headroom.unfreeze(); + frozen = false; + } else { + headroom.freeze(); + frozen = true; + } + }; + } + + window.addEventListener( + "hashchange", + function (e) { + if ( + getComputedStyle(document.documentElement).scrollBehavior !== "smooth" + ) { + window.scrollTo(0, window.pageYOffset - headerOffset()); + } + }, + false + ); + + // Observe size changed for the header + const headerEl = window.document.querySelector("header.fixed-top"); + if (headerEl && window.ResizeObserver) { + const observer = new window.ResizeObserver( + updateDocumentOffsetWithoutAnimation + ); + observer.observe(headerEl, { + attributes: true, + childList: true, + characterData: true, + }); + } else { + window.addEventListener( + "resize", + throttle(updateDocumentOffsetWithoutAnimation, 50) + ); + } + setTimeout(updateDocumentOffsetWithoutAnimation, 250); + + // fixup index.html links if we aren't on the filesystem + if (window.location.protocol !== "file:") { + const links = window.document.querySelectorAll("a"); + for (let i = 0; i < links.length; i++) { + if (links[i].href) { + links[i].href = links[i].href.replace(/\/index\.html/, "/"); + } + } + + // Fixup any sharing links that require urls + // Append url to any sharing urls + const sharingLinks = window.document.querySelectorAll( + "a.sidebar-tools-main-item" + ); + for (let i = 0; i < sharingLinks.length; i++) { + const sharingLink = sharingLinks[i]; + const href = sharingLink.getAttribute("href"); + if (href) { + sharingLink.setAttribute( + "href", + href.replace("|url|", window.location.href) + ); + } + } + + // Scroll the active navigation item into view, if necessary + const navSidebar = window.document.querySelector("nav#quarto-sidebar"); + if (navSidebar) { + // Find the active item + const activeItem = navSidebar.querySelector("li.sidebar-item a.active"); + if (activeItem) { + // Wait for the scroll height and height to resolve by observing size changes on the + // nav element that is scrollable + const resizeObserver = new 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a/docs/site_libs/quarto-search/quarto-search.js b/docs/site_libs/quarto-search/quarto-search.js new file mode 100644 index 0000000..f5d852d --- /dev/null +++ b/docs/site_libs/quarto-search/quarto-search.js @@ -0,0 +1,1140 @@ +const kQueryArg = "q"; +const kResultsArg = "show-results"; + +// If items don't provide a URL, then both the navigator and the onSelect +// function aren't called (and therefore, the default implementation is used) +// +// We're using this sentinel URL to signal to those handlers that this +// item is a more item (along with the type) and can be handled appropriately +const kItemTypeMoreHref = "0767FDFD-0422-4E5A-BC8A-3BE11E5BBA05"; + +window.document.addEventListener("DOMContentLoaded", function (_event) { + // Ensure that search is available on this page. If it isn't, + // should return early and not do anything + var searchEl = window.document.getElementById("quarto-search"); + if (!searchEl) return; + + const { autocomplete } = window["@algolia/autocomplete-js"]; + + let quartoSearchOptions = {}; + let language = {}; + const searchOptionEl = window.document.getElementById( + "quarto-search-options" + ); + if (searchOptionEl) { + const jsonStr = searchOptionEl.textContent; + quartoSearchOptions = JSON.parse(jsonStr); + language = quartoSearchOptions.language; + } + + // note the search mode + if (quartoSearchOptions.type === "overlay") { + searchEl.classList.add("type-overlay"); + } else { + searchEl.classList.add("type-textbox"); + } + + // Used to determine highlighting behavior for this page + // A `q` query param is expected when the user follows a search + // to this page + const currentUrl = new URL(window.location); + const query = currentUrl.searchParams.get(kQueryArg); + const showSearchResults = currentUrl.searchParams.get(kResultsArg); + const mainEl = window.document.querySelector("main"); + + // highlight matches on the page + if (query !== null && mainEl) { + // perform any highlighting + highlight(escapeRegExp(query), mainEl); + + // fix up the URL to remove the q query param + const replacementUrl = new URL(window.location); + replacementUrl.searchParams.delete(kQueryArg); + window.history.replaceState({}, "", replacementUrl); + } + + // function to clear highlighting on the page when the search query changes + // (e.g. if the user edits the query or clears it) + let highlighting = true; + const resetHighlighting = (searchTerm) => { + if (mainEl && highlighting && query !== null && searchTerm !== query) { + clearHighlight(query, mainEl); + highlighting = false; + } + }; + + // Clear search highlighting when the user scrolls sufficiently + const resetFn = () => { + resetHighlighting(""); + window.removeEventListener("quarto-hrChanged", resetFn); + window.removeEventListener("quarto-sectionChanged", resetFn); + }; + + // Register this event after the initial scrolling and settling of events + // on the page + window.addEventListener("quarto-hrChanged", resetFn); + window.addEventListener("quarto-sectionChanged", resetFn); + + // Responsively switch to overlay mode if the search is present on the navbar + // Note that switching the sidebar to overlay mode requires more coordinate (not just + // the media query since we generate different HTML for sidebar overlays than we do + // for sidebar input UI) + const detachedMediaQuery = + quartoSearchOptions.type === "overlay" ? "all" : "(max-width: 991px)"; + + // If configured, include the analytics client to send insights + const plugins = configurePlugins(quartoSearchOptions); + + let lastState = null; + const { setIsOpen, setQuery, setCollections } = autocomplete({ + container: searchEl, + detachedMediaQuery: detachedMediaQuery, + defaultActiveItemId: 0, + panelContainer: "#quarto-search-results", + panelPlacement: quartoSearchOptions["panel-placement"], + debug: false, + openOnFocus: true, + plugins, + classNames: { + form: "d-flex", + }, + translations: { + clearButtonTitle: language["search-clear-button-title"], + detachedCancelButtonText: language["search-detached-cancel-button-title"], + submitButtonTitle: language["search-submit-button-title"], + }, + initialState: { + query, + }, + getItemUrl({ item }) { + return item.href; + }, + onStateChange({ state }) { + // Perhaps reset highlighting + resetHighlighting(state.query); + + // If the panel just opened, ensure the panel is positioned properly + if (state.isOpen) { + if (lastState && !lastState.isOpen) { + setTimeout(() => { + positionPanel(quartoSearchOptions["panel-placement"]); + }, 150); + } + } + + // Perhaps show the copy link + showCopyLink(state.query, quartoSearchOptions); + + lastState = state; + }, + reshape({ sources, state }) { + return sources.map((source) => { + try { + const items = source.getItems(); + + // Validate the items + validateItems(items); + + // group the items by document + const groupedItems = new Map(); + items.forEach((item) => { + const hrefParts = item.href.split("#"); + const baseHref = hrefParts[0]; + const isDocumentItem = hrefParts.length === 1; + + const items = groupedItems.get(baseHref); + if (!items) { + groupedItems.set(baseHref, [item]); + } else { + // If the href for this item matches the document + // exactly, place this item first as it is the item that represents + // the document itself + if (isDocumentItem) { + items.unshift(item); + } else { + items.push(item); + } + groupedItems.set(baseHref, items); + } + }); + + const reshapedItems = []; + let count = 1; + for (const [_key, value] of groupedItems) { + const firstItem = value[0]; + reshapedItems.push({ + ...firstItem, + type: kItemTypeDoc, + }); + + const collapseMatches = quartoSearchOptions["collapse-after"]; + const collapseCount = + typeof collapseMatches === "number" ? collapseMatches : 1; + + if (value.length > 1) { + const target = `search-more-${count}`; + const isExpanded = + state.context.expanded && + state.context.expanded.includes(target); + + const remainingCount = value.length - collapseCount; + + for (let i = 1; i < value.length; i++) { + if (collapseMatches && i === collapseCount) { + reshapedItems.push({ + target, + title: isExpanded + ? language["search-hide-matches-text"] + : remainingCount === 1 + ? `${remainingCount} ${language["search-more-match-text"]}` + : `${remainingCount} ${language["search-more-matches-text"]}`, + type: kItemTypeMore, + href: kItemTypeMoreHref, + }); + } + + if (isExpanded || !collapseMatches || i < collapseCount) { + reshapedItems.push({ + ...value[i], + type: kItemTypeItem, + target, + }); + } + } + } + count += 1; + } + + return { + ...source, + getItems() { + return reshapedItems; + }, + }; + } catch (error) { + // Some form of error occurred + return { + ...source, + getItems() { + return [ + { + title: error.name || "An Error Occurred While Searching", + text: + error.message || + "An unknown error occurred while attempting to perform the requested search.", + type: kItemTypeError, + }, + ]; + }, + }; + } + }); + }, + navigator: { + navigate({ itemUrl }) { + if (itemUrl !== offsetURL(kItemTypeMoreHref)) { + window.location.assign(itemUrl); + } + }, + navigateNewTab({ itemUrl }) { + if (itemUrl !== offsetURL(kItemTypeMoreHref)) { + const windowReference = window.open(itemUrl, "_blank", "noopener"); + if (windowReference) { + windowReference.focus(); + } + } + }, + navigateNewWindow({ itemUrl }) { + if (itemUrl !== offsetURL(kItemTypeMoreHref)) { + window.open(itemUrl, "_blank", "noopener"); + } + }, + }, + getSources({ state, setContext, setActiveItemId, refresh }) { + return [ + { + sourceId: "documents", + getItemUrl({ item }) { + if (item.href) { + return offsetURL(item.href); + } else { + return undefined; + } + }, + onSelect({ + item, + state, + setContext, + setIsOpen, + setActiveItemId, + refresh, + }) { + if (item.type === kItemTypeMore) { + toggleExpanded(item, state, setContext, setActiveItemId, refresh); + + // Toggle more + setIsOpen(true); + } + }, + getItems({ query }) { + if (query === null || query === "") { + return []; + } + + const limit = quartoSearchOptions.limit; + if (quartoSearchOptions.algolia) { + return algoliaSearch(query, limit, quartoSearchOptions.algolia); + } else { + // Fuse search options + const fuseSearchOptions = { + isCaseSensitive: false, + shouldSort: true, + minMatchCharLength: 2, + limit: limit, + }; + + return readSearchData().then(function (fuse) { + return fuseSearch(query, fuse, fuseSearchOptions); + }); + } + }, + templates: { + noResults({ createElement }) { + const hasQuery = lastState.query; + + return createElement( + "div", + { + class: `quarto-search-no-results${ + hasQuery ? "" : " no-query" + }`, + }, + language["search-no-results-text"] + ); + }, + header({ items, createElement }) { + // count the documents + const count = items.filter((item) => { + return item.type === kItemTypeDoc; + }).length; + + if (count > 0) { + return createElement( + "div", + { class: "search-result-header" }, + `${count} ${language["search-matching-documents-text"]}` + ); + } else { + return createElement( + "div", + { class: "search-result-header-no-results" }, + `` + ); + } + }, + footer({ _items, createElement }) { + if ( + quartoSearchOptions.algolia && + quartoSearchOptions.algolia["show-logo"] + ) { + const libDir = quartoSearchOptions.algolia["libDir"]; + const logo = createElement("img", { + src: offsetURL( + `${libDir}/quarto-search/search-by-algolia.svg` + ), + class: "algolia-search-logo", + }); + return createElement( + "a", + { href: "http://www.algolia.com/" }, + logo + ); + } + }, + + item({ item, createElement }) { + return renderItem( + item, + createElement, + state, + setActiveItemId, + setContext, + refresh + ); + }, + }, + }, + ]; + }, + }); + + window.quartoOpenSearch = () => { + setIsOpen(false); + setIsOpen(true); + focusSearchInput(); + }; + + // Remove the labeleledby attribute since it is pointing + // to a non-existent label + if (quartoSearchOptions.type === "overlay") { + const inputEl = window.document.querySelector( + "#quarto-search .aa-Autocomplete" + ); + if (inputEl) { + inputEl.removeAttribute("aria-labelledby"); + } + } + + // If the main document scrolls dismiss the search results + // (otherwise, since they're floating in the document they can scroll with the document) + window.document.body.onscroll = () => { + setIsOpen(false); + }; + + if (showSearchResults) { + setIsOpen(true); + focusSearchInput(); + } +}); + +function configurePlugins(quartoSearchOptions) { + const autocompletePlugins = []; + const algoliaOptions = quartoSearchOptions.algolia; + if ( + algoliaOptions && + algoliaOptions["analytics-events"] && + algoliaOptions["search-only-api-key"] && + algoliaOptions["application-id"] + ) { + const apiKey = algoliaOptions["search-only-api-key"]; + const appId = algoliaOptions["application-id"]; + + // Aloglia insights may not be loaded because they require cookie consent + // Use deferred loading so events will start being recorded when/if consent + // is granted. + const algoliaInsightsDeferredPlugin = deferredLoadPlugin(() => { + if ( + window.aa && + window["@algolia/autocomplete-plugin-algolia-insights"] + ) { + window.aa("init", { + appId, + apiKey, + useCookie: true, + }); + + const { createAlgoliaInsightsPlugin } = + window["@algolia/autocomplete-plugin-algolia-insights"]; + // Register the insights client + const algoliaInsightsPlugin = createAlgoliaInsightsPlugin({ + insightsClient: window.aa, + onItemsChange({ insights, insightsEvents }) { + const events = insightsEvents.map((event) => { + const maxEvents = event.objectIDs.slice(0, 20); + return { + ...event, + objectIDs: maxEvents, + }; + }); + + insights.viewedObjectIDs(...events); + }, + }); + return algoliaInsightsPlugin; + } + }); + + // Add the plugin + autocompletePlugins.push(algoliaInsightsDeferredPlugin); + return autocompletePlugins; + } +} + +// For plugins that may not load immediately, create a wrapper +// plugin and forward events and plugin data once the plugin +// is initialized. This is useful for cases like cookie consent +// which may prevent the analytics insights event plugin from initializing +// immediately. +function deferredLoadPlugin(createPlugin) { + let plugin = undefined; + let subscribeObj = undefined; + const wrappedPlugin = () => { + if (!plugin && subscribeObj) { + plugin = createPlugin(); + if (plugin && plugin.subscribe) { + plugin.subscribe(subscribeObj); + } + } + return plugin; + }; + + return { + subscribe: (obj) => { + subscribeObj = obj; + }, + onStateChange: (obj) => { + const plugin = wrappedPlugin(); + if (plugin && plugin.onStateChange) { + plugin.onStateChange(obj); + } + }, + onSubmit: (obj) => { + const plugin = wrappedPlugin(); + if (plugin && plugin.onSubmit) { + plugin.onSubmit(obj); + } + }, + onReset: (obj) => { + const plugin = wrappedPlugin(); + if (plugin && plugin.onReset) { + plugin.onReset(obj); + } + }, + getSources: (obj) => { + const plugin = wrappedPlugin(); + if (plugin && plugin.getSources) { + return plugin.getSources(obj); + } else { + return Promise.resolve([]); + } + }, + data: (obj) => { + const plugin = wrappedPlugin(); + if (plugin && plugin.data) { + plugin.data(obj); + } + }, + }; +} + +function validateItems(items) { + // Validate the first item + if (items.length > 0) { + const item = items[0]; + const missingFields = []; + if (item.href == undefined) { + missingFields.push("href"); + } + if (!item.title == undefined) { + missingFields.push("title"); + } + if (!item.text == undefined) { + missingFields.push("text"); + } + + if (missingFields.length === 1) { + throw { + name: `Error: Search index is missing the ${missingFields[0]} field.`, + message: `The items being returned for this search do not include all the required fields. Please ensure that your index items include the ${missingFields[0]} field or use index-fields in your _quarto.yml file to specify the field names.`, + }; + } else if (missingFields.length > 1) { + const missingFieldList = missingFields + .map((field) => { + return `${field}`; + }) + .join(", "); + + throw { + name: `Error: Search index is missing the following fields: ${missingFieldList}.`, + message: `The items being returned for this search do not include all the required fields. Please ensure that your index items includes the following fields: ${missingFieldList}, or use index-fields in your _quarto.yml file to specify the field names.`, + }; + } + } +} + +let lastQuery = null; +function showCopyLink(query, options) { + const language = options.language; + lastQuery = query; + // Insert share icon + const inputSuffixEl = window.document.body.querySelector( + ".aa-Form .aa-InputWrapperSuffix" + ); + + if (inputSuffixEl) { + let copyButtonEl = window.document.body.querySelector( + ".aa-Form .aa-InputWrapperSuffix .aa-CopyButton" + ); + + if (copyButtonEl === null) { + copyButtonEl = window.document.createElement("button"); + copyButtonEl.setAttribute("class", "aa-CopyButton"); + copyButtonEl.setAttribute("type", "button"); + copyButtonEl.setAttribute("title", language["search-copy-link-title"]); + copyButtonEl.onmousedown = (e) => { + e.preventDefault(); + e.stopPropagation(); + }; + + const linkIcon = "bi-clipboard"; + const checkIcon = "bi-check2"; + + const shareIconEl = window.document.createElement("i"); + shareIconEl.setAttribute("class", `bi ${linkIcon}`); + copyButtonEl.appendChild(shareIconEl); + inputSuffixEl.prepend(copyButtonEl); + + const clipboard = new window.ClipboardJS(".aa-CopyButton", { + text: function (_trigger) { + const copyUrl = new URL(window.location); + copyUrl.searchParams.set(kQueryArg, lastQuery); + copyUrl.searchParams.set(kResultsArg, "1"); + return copyUrl.toString(); + }, + }); + clipboard.on("success", function (e) { + // Focus the input + + // button target + const button = e.trigger; + const icon = button.querySelector("i.bi"); + + // flash "checked" + icon.classList.add(checkIcon); + icon.classList.remove(linkIcon); + setTimeout(function () { + icon.classList.remove(checkIcon); + icon.classList.add(linkIcon); + }, 1000); + }); + } + + // If there is a query, show the link icon + if (copyButtonEl) { + if (lastQuery && options["copy-button"]) { + copyButtonEl.style.display = "flex"; + } else { + copyButtonEl.style.display = "none"; + } + } + } +} + +/* Search Index Handling */ +// create the index +var fuseIndex = undefined; +async function readSearchData() { + // Initialize the search index on demand + if (fuseIndex === undefined) { + // create fuse index + const options = { + keys: [ + { name: "title", weight: 20 }, + { name: "section", weight: 20 }, + { name: "text", weight: 10 }, + ], + ignoreLocation: true, + threshold: 0.1, + }; + const fuse = new window.Fuse([], options); + + // fetch the main search.json + const response = await fetch(offsetURL("search.json")); + if (response.status == 200) { + return response.json().then(function (searchDocs) { + searchDocs.forEach(function (searchDoc) { + fuse.add(searchDoc); + }); + fuseIndex = fuse; + return fuseIndex; + }); + } else { + return Promise.reject( + new Error( + "Unexpected status from search index request: " + response.status + ) + ); + } + } + return fuseIndex; +} + +function inputElement() { + return window.document.body.querySelector(".aa-Form .aa-Input"); +} + +function focusSearchInput() { + setTimeout(() => { + const inputEl = inputElement(); + if (inputEl) { + inputEl.focus(); + } + }, 50); +} + +/* Panels */ +const kItemTypeDoc = "document"; +const kItemTypeMore = "document-more"; +const kItemTypeItem = "document-item"; +const kItemTypeError = "error"; + +function renderItem( + item, + createElement, + state, + setActiveItemId, + setContext, + refresh +) { + switch (item.type) { + case kItemTypeDoc: + return createDocumentCard( + createElement, + "file-richtext", + item.title, + item.section, + item.text, + item.href + ); + case kItemTypeMore: + return createMoreCard( + createElement, + item, + state, + setActiveItemId, + setContext, + refresh + ); + case kItemTypeItem: + return createSectionCard( + createElement, + item.section, + item.text, + item.href + ); + case kItemTypeError: + return createErrorCard(createElement, item.title, item.text); + default: + return undefined; + } +} + +function createDocumentCard(createElement, icon, title, section, text, href) { + const iconEl = createElement("i", { + class: `bi bi-${icon} search-result-icon`, + }); + const titleEl = createElement("p", { class: "search-result-title" }, title); + const titleContainerEl = createElement( + "div", + { class: "search-result-title-container" }, + [iconEl, titleEl] + ); + + const textEls = []; + if (section) { + const sectionEl = createElement( + "p", + { class: "search-result-section" }, + section + ); + textEls.push(sectionEl); + } + const descEl = createElement("p", { + class: "search-result-text", + dangerouslySetInnerHTML: { + __html: text, + }, + }); + textEls.push(descEl); + + const textContainerEl = createElement( + "div", + { class: "search-result-text-container" }, + textEls + ); + + const containerEl = createElement( + "div", + { + class: "search-result-container", + }, + [titleContainerEl, textContainerEl] + ); + + const linkEl = createElement( + "a", + { + href: offsetURL(href), + class: "search-result-link", + }, + containerEl + ); + + const classes = ["search-result-doc", "search-item"]; + if (!section) { + classes.push("document-selectable"); + } + + return createElement( + "div", + { + class: classes.join(" "), + }, + linkEl + ); +} + +function createMoreCard( + createElement, + item, + state, + setActiveItemId, + setContext, + refresh +) { + const moreCardEl = createElement( + "div", + { + class: "search-result-more search-item", + onClick: (e) => { + // Handle expanding the sections by adding the expanded + // section to the list of expanded sections + toggleExpanded(item, state, setContext, setActiveItemId, refresh); + e.stopPropagation(); + }, + }, + item.title + ); + + return moreCardEl; +} + +function toggleExpanded(item, state, setContext, setActiveItemId, refresh) { + const expanded = state.context.expanded || []; + if (expanded.includes(item.target)) { + setContext({ + expanded: expanded.filter((target) => target !== item.target), + }); + } else { + setContext({ expanded: [...expanded, item.target] }); + } + + refresh(); + setActiveItemId(item.__autocomplete_id); +} + +function createSectionCard(createElement, section, text, href) { + const sectionEl = createSection(createElement, section, text, href); + return createElement( + "div", + { + class: "search-result-doc-section search-item", + }, + sectionEl + ); +} + +function createSection(createElement, title, text, href) { + const descEl = createElement("p", { + class: "search-result-text", + dangerouslySetInnerHTML: { + __html: text, + }, + }); + + const titleEl = createElement("p", { class: "search-result-section" }, title); + const linkEl = createElement( + "a", + { + href: offsetURL(href), + class: "search-result-link", + }, + [titleEl, descEl] + ); + return linkEl; +} + +function createErrorCard(createElement, title, text) { + const descEl = createElement("p", { + class: "search-error-text", + dangerouslySetInnerHTML: { + __html: text, + }, + }); + + const titleEl = createElement("p", { + class: "search-error-title", + dangerouslySetInnerHTML: { + __html: ` ${title}`, + }, + }); + const errorEl = createElement("div", { class: "search-error" }, [ + titleEl, + descEl, + ]); + return errorEl; +} + +function positionPanel(pos) { + const panelEl = window.document.querySelector( + "#quarto-search-results .aa-Panel" + ); + const inputEl = window.document.querySelector( + "#quarto-search .aa-Autocomplete" + ); + + if (panelEl && inputEl) { + panelEl.style.top = `${Math.round(panelEl.offsetTop)}px`; + if (pos === "start") { + panelEl.style.left = `${Math.round(inputEl.left)}px`; + } else { + panelEl.style.right = `${Math.round(inputEl.offsetRight)}px`; + } + } +} + +/* Highlighting */ +// highlighting functions +function highlightMatch(query, text) { + if (text) { + const start = text.toLowerCase().indexOf(query.toLowerCase()); + if (start !== -1) { + const startMark = ""; + const endMark = ""; + + const end = start + query.length; + text = + text.slice(0, start) + + startMark + + text.slice(start, end) + + endMark + + text.slice(end); + const startInfo = clipStart(text, start); + const endInfo = clipEnd( + text, + startInfo.position + startMark.length + endMark.length + ); + text = + startInfo.prefix + + text.slice(startInfo.position, endInfo.position) + + endInfo.suffix; + + return text; + } else { + return text; + } + } else { + return text; + } +} + +function clipStart(text, pos) { + const clipStart = pos - 50; + if (clipStart < 0) { + // This will just return the start of the string + return { + position: 0, + prefix: "", + }; + } else { + // We're clipping before the start of the string, walk backwards to the first space. + const spacePos = findSpace(text, pos, -1); + return { + position: spacePos.position, + prefix: "", + }; + } +} + +function clipEnd(text, pos) { + const clipEnd = pos + 200; + if (clipEnd > text.length) { + return { + position: text.length, + suffix: "", + }; + } else { + const spacePos = findSpace(text, clipEnd, 1); + return { + position: spacePos.position, + suffix: spacePos.clipped ? "…" : "", + }; + } +} + +function findSpace(text, start, step) { + let stepPos = start; + while (stepPos > -1 && stepPos < text.length) { + const char = text[stepPos]; + if (char === " " || char === "," || char === ":") { + return { + position: step === 1 ? stepPos : stepPos - step, + clipped: stepPos > 1 && stepPos < text.length, + }; + } + stepPos = stepPos + step; + } + + return { + position: stepPos - step, + clipped: false, + }; +} + +// removes highlighting as implemented by the mark tag +function clearHighlight(searchterm, el) { + const childNodes = el.childNodes; + for (let i = childNodes.length - 1; i >= 0; i--) { + const node = childNodes[i]; + if (node.nodeType === Node.ELEMENT_NODE) { + if ( + node.tagName === "MARK" && + node.innerText.toLowerCase() === searchterm.toLowerCase() + ) { + el.replaceChild(document.createTextNode(node.innerText), node); + } else { + clearHighlight(searchterm, node); + } + } + } +} + +function escapeRegExp(string) { + return string.replace(/[.*+?^${}()|[\]\\]/g, "\\$&"); // $& means the whole matched string +} + +// highlight matches +function highlight(term, el) { + const termRegex = new RegExp(term, "ig"); + const childNodes = el.childNodes; + + // walk back to front avoid mutating elements in front of us + for (let i = childNodes.length - 1; i >= 0; i--) { + const node = childNodes[i]; + + if (node.nodeType === Node.TEXT_NODE) { + // Search text nodes for text to highlight + const text = node.nodeValue; + + let startIndex = 0; + let matchIndex = text.search(termRegex); + if (matchIndex > -1) { + const markFragment = document.createDocumentFragment(); + while (matchIndex > -1) { + const prefix = text.slice(startIndex, matchIndex); + markFragment.appendChild(document.createTextNode(prefix)); + + const mark = document.createElement("mark"); + mark.appendChild( + document.createTextNode( + text.slice(matchIndex, matchIndex + term.length) + ) + ); + markFragment.appendChild(mark); + + startIndex = matchIndex + term.length; + matchIndex = text.slice(startIndex).search(new RegExp(term, "ig")); + if (matchIndex > -1) { + matchIndex = startIndex + matchIndex; + } + } + if (startIndex < text.length) { + markFragment.appendChild( + document.createTextNode(text.slice(startIndex, text.length)) + ); + } + + el.replaceChild(markFragment, node); + } + } else if (node.nodeType === Node.ELEMENT_NODE) { + // recurse through elements + highlight(term, node); + } + } +} + +/* Link Handling */ +// get the offset from this page for a given site root relative url +function offsetURL(url) { + var offset = getMeta("quarto:offset"); + return offset ? offset + url : url; +} + +// read a meta tag value +function getMeta(metaName) { + var metas = window.document.getElementsByTagName("meta"); + for (let i = 0; i < metas.length; i++) { + if (metas[i].getAttribute("name") === metaName) { + return metas[i].getAttribute("content"); + } + } + return ""; +} + +function algoliaSearch(query, limit, algoliaOptions) { + const { getAlgoliaResults } = window["@algolia/autocomplete-preset-algolia"]; + + const applicationId = algoliaOptions["application-id"]; + const searchOnlyApiKey = algoliaOptions["search-only-api-key"]; + const indexName = algoliaOptions["index-name"]; + const indexFields = algoliaOptions["index-fields"]; + const searchClient = window.algoliasearch(applicationId, searchOnlyApiKey); + const searchParams = algoliaOptions["params"]; + const searchAnalytics = !!algoliaOptions["analytics-events"]; + + return getAlgoliaResults({ + searchClient, + queries: [ + { + indexName: indexName, + query, + params: { + hitsPerPage: limit, + clickAnalytics: searchAnalytics, + ...searchParams, + }, + }, + ], + transformResponse: (response) => { + if (!indexFields) { + return response.hits.map((hit) => { + return hit.map((item) => { + return { + ...item, + text: highlightMatch(query, item.text), + }; + }); + }); + } else { + const remappedHits = response.hits.map((hit) => { + return hit.map((item) => { + const newItem = { ...item }; + ["href", "section", "title", "text"].forEach((keyName) => { + const mappedName = indexFields[keyName]; + if ( + mappedName && + item[mappedName] !== undefined && + mappedName !== keyName + ) { + newItem[keyName] = item[mappedName]; + delete newItem[mappedName]; + } + }); + newItem.text = highlightMatch(query, newItem.text); + return newItem; + }); + }); + return remappedHits; + } + }, + }); +} + +function fuseSearch(query, fuse, fuseOptions) { + return fuse.search(query, fuseOptions).map((result) => { + const addParam = (url, name, value) => { + const anchorParts = url.split("#"); + const baseUrl = anchorParts[0]; + const sep = baseUrl.search("\\?") > 0 ? "&" : "?"; + anchorParts[0] = baseUrl + sep + name + "=" + value; + return anchorParts.join("#"); + }; + + return { + title: result.item.title, + section: result.item.section, + href: addParam(result.item.href, kQueryArg, query), + text: highlightMatch(query, result.item.text), + }; + }); +} diff --git a/docs/statistics/index.html b/docs/statistics/index.html new file mode 100644 index 0000000..3b39a20 --- /dev/null +++ b/docs/statistics/index.html @@ -0,0 +1,3297 @@ + + + + + + + + + +SHFDB4 - Statistics + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
+
+ +
+ +
+ + + + +
+ +
+
+

Statistics

+
+ + + +
+ + + + +
+ + +
+ +
+

Over time - interactive

+

Descriptive statistics over time can be found: https://swedehf.shinyapps.io/deskstatshfdb4

+
+
+
+

Descriptive statistics

+
+ +
+
+
+ ++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+Patients (last post) +
+Posts +
Variable% missingSwedeHF% missingSwedeHFCase NPRControl SwedeHFControl NPR
n114375206634422876388838782222
ncontrols0.02.0 [2.0, 2.0]0.02.0 [2.0, 2.0]2.0 [2.0, 2.0]0.0 [0.0, 0.0]0.0 [0.0, 0.0]
Time in hospital at index hospitalization (days)160.95.0 [3.0, 9.0]63.85.0 [3.0, 9.0]
Index year10.02015.0 [2010.0, 2019.0]0.02014.0 [2010.0, 2018.0]2011.0 [2005.0, 2016.0]2014.0 [2010.0, 2018.0]2010.0 [2005.0, 2016.0]
Type of visit Index10.068651 (60.0)0.0115634 (56.0)
LVEF (%)185.640.0 [30.0, 50.0]86.539.0 [30.0, 45.0]
LVEF (%)119.917.1
    ≥5023497 (25.7)38003 (22.2)
    40-4922033 (24.1)39894 (23.3)
    30-3923867 (26.1)46520 (27.2)
    <3022177 (24.2)46790 (27.3)
LVEF (%)119.917.1
    HFrEF46044 (50.3)93310 (54.5)
    HFmrEF22033 (24.1)39894 (23.3)
    HFpEF23497 (25.7)38003 (22.2)
Sex Male10.070503 (61.6)0.0132380 (64.1)226402 (53.5)244109 (62.8)408993 (52.3)
Age (years)10.077.0 [69.0, 84.0]0.076.0 [67.0, 83.0]80.0 [71.0, 86.0]75.0 [67.0, 82.0]79.0 [70.0, 85.0]
Civil status Single127.936905 (44.8)27.563189 (42.2)
Living conditions Own home144.559898 (94.4)44.4110190 (95.8)
Location In-patient10.044750 (39.1)0.074851 (36.2)
Smoking126.923.3
    Current9116 (10.9)17267 (10.9)
    Former36685 (43.9)70920 (44.8)
    Never37769 (45.2)70225 (44.3)
Smoking126.99116 (10.9)23.317267 (10.9)
Alcohol Risk142.52836 (4.3)38.95179 (4.1)
Duration of HF ≥6mo12.868600 (61.7)2.5124933 (62.0)
Primary etiology140.940.3
    DCM4597 (6.8)10169 (8.2)
    Heart valve disease5387 (8.0)9187 (7.4)
    Hypertension17917 (26.5)31520 (25.5)
    IHD26407 (39.1)50168 (40.6)
    Known alcoholic cardiomyopathy467 (0.7)898 (0.7)
    Other12828 (19.0)21510 (17.4)
NYHA class130.026.1
    I10233 (12.8)17921 (11.7)
    II37273 (46.5)73193 (48.0)
    III29222 (36.5)56325 (36.9)
    IV3390 (4.2)5173 (3.4)
NYHA class III-IV130.032612 (40.7)26.161498 (40.3)
Killip class194.495.8
    Chock or hypertension17 (0.3)27 (0.3)
    Edema160 (2.5)217 (2.5)
    No signs of HF2904 (45.4)4128 (47.3)
    Rales or crackles3310 (51.8)4349 (49.9)
Weight (kg)112.977.4 [66.0, 90.0]11.879.0 [67.8, 91.5]
Weight at admission/visit (kg)132.778.0 [66.4, 90.4]37.279.0 [68.0, 91.8]
Weight at discharge   (hospitalized patients) (kg)194.875.5 [63.5, 88.7]96.177.0 [65.0, 90.0]
Height (cm)132.0172.0 [164.0, 179.0]26.0172.0 [165.0, 179.0]
Systolic blood pressure (mmHg)13.9125.0 [110.0, 140.0]3.3125.0 [110.0, 140.0]
Systolic blood pressure at admission/visit (mmHg)125.0126.0 [112.0, 140.0]30.4125.0 [112.0, 140.0]
Systolic blood pressure at discharge   (hospitalized patients) (mmHg)194.0125.0 [111.0, 140.0]95.5125.0 [110.0, 140.0]
Diastolic blood pressure (mmHg)13.870.0 [65.0, 80.0]3.270.0 [65.0, 80.0]
Diastolic blood pressure at admission/visit (mmHg)125.072.0 [65.0, 80.0]30.372.0 [65.0, 80.0]
Diastolic blood pressure at discharge   (hospitalized patients) (mmHg)193.972.0 [65.0, 80.0]95.572.0 [65.0, 80.0]
Mean arterial pressure13.890.0 [81.7, 99.7]3.290.0 [81.7, 99.0]
Mean arterial pressure >9013.852421 (47.6)3.294489 (47.2)
Heart rate (beats/min)16.571.0 [63.0, 82.0]5.771.0 [63.0, 81.0]
Heart rate at admission/visit (beats/min)127.072.0 [63.0, 83.0]32.171.0 [63.0, 82.0]
Heart rate at discharge   (hospitalized patients) (beats/min)194.274.0 [65.0, 85.0]95.674.0 [65.0, 85.0]
Heart rate (beats/min) >7016.555096 (51.5)5.798701 (50.7)
Hemoglobin (g/L)18.2131.0 [118.0, 143.0]8.1132.0 [120.0, 144.0]
Hemoglobin at admission/visit (g/L)129.2132.0 [119.0, 144.0]34.7133.0 [120.0, 145.0]
Hemoglobin at discharge   (hospitalized patients) (g/L)196.3119.0 [106.0, 135.0]97.2122.0 [107.0, 137.0]
Anemia18.239397 (37.5)8.166947 (35.2)
Potassium (mmol/L)119.94.2 [3.9, 4.5]18.74.2 [3.9, 4.5]
Potassium at admission/visit (mmol/L)136.04.2 [3.9, 4.5]39.94.2 [3.9, 4.5]
Potassium at discharge   (hospitalized patients) (mmol/L)194.84.0 [3.7, 4.3]96.14.0 [3.7, 4.3]
Potassium (mmol/L)119.918.7
    Normakalemia83777 (91.5)155018 (92.3)
    Hypokalemia4060 (4.4)6444 (3.8)
    Hyperkalemia3725 (4.1)6446 (3.8)
Sodium (mmol/l)135.0140.0 [138.0, 142.0]35.1140.0 [138.0, 142.0]
Sodium at admission/visit (mmol/l)146.8140.0 [138.0, 142.0]50.5140.0 [138.0, 142.0]
Sodium at discharge   (hospitalized patients) (mmol/l)195.0140.0 [138.0, 142.0]96.2140.0 [138.0, 142.0]
Creatinine (µmol/L)13.297.0 [79.0, 126.0]2.997.0 [79.0, 124.0]
Creatinine at admission/visit (µmol/L)124.695.0 [78.0, 122.0]30.294.0 [77.0, 119.0]
Creatinine at discharge   (hospitalized patients) (µmol/L)194.8100.0 [78.0, 133.0]96.197.0 [78.0, 128.0]
eGFR (mL/min/1.73 m²)12.962.7 [44.8, 82.7]2.764.0 [46.4, 83.4]
eGFR (mL/min/1.73 m²) <6012.951262 (46.2)2.788931 (44.2)
NT-proBNP (pg/ml)144.72066.0 [812.0, 4950.0]44.12000.0 [810.0, 4563.0]
NT-proBNP at admission/visit (pg/ml)155.01971.0 [770.0, 4633.0]57.61900.0 [765.0, 4296.0]
NT-proBNP at discharge   (hospitalized patients) (pg/ml)197.93660.0 [1657.0, 8656.5]98.43380.0 [1574.0, 7652.5]
BNP (pg/ml)195.6580.0 [219.0, 1335.5]95.1527.0 [202.0, 1230.0]
Transferrin (%)189.724.0 [17.0, 32.0]90.524.0 [17.0, 33.0]
Ferritin (µg/l)187.9142.0 [71.0, 264.0]88.8142.0 [71.0, 262.0]
QRS width (ms)122.3104.0 [90.0, 132.0]22.2106.0 [92.0, 136.0]
Left Bundle Branch Block (LBBB)121.715800 (17.6)21.730529 (18.9)
Loop diuretic IV181.35479 (25.5)82.37554 (20.6)
Ferric carboxymaltose IV157.22501 (5.1)59.63917 (4.7)
Ferric carboxymaltose IV dose (mg)197.91000.0 [1000.0, 1000.0]98.21000.0 [1000.0, 1000.0]
Unplanned inotrope support139.41356 (2.0)40.03640 (2.9)
Diuretic10.686951 (76.5)0.5158572 (77.1)
Loop diuretic127.460440 (72.8)27.8108999 (73.1)
Loop diuretic substance172.975.5
    Bumetanid230 (0.7)339 (0.7)
    Furosemid30618 (98.8)50174 (98.9)
    Toresamid127 (0.4)203 (0.4)
Loop diuretic dose (mg/24h)154.940.0 [40.0, 80.0]54.640.0 [40.0, 80.0]
Loop diuretic usage When necessary147.311615 (19.3)47.420892 (19.2)
ACEi10.654926 (48.3)0.4104596 (50.8)
ACEi dose (mg/24h)152.110.0 [5.0, 15.0]49.510.0 [5.0, 15.0]
ARB11.130970 (27.4)0.959400 (29.0)
ARB dose (mg/24h)173.032.0 [15.0, 50.0]71.332.0 [12.5, 50.0]
ARNi156.06960 (13.8)58.611611 (13.6)
ACEi/ARB/ARNi11.391155 (80.7)1.1172045 (84.1)
Beta-blocker10.598019 (86.1)0.4180675 (87.8)
Beta-blocker dose (mg/24h)114.525.0 [7.5, 100.0]12.825.0 [7.5, 100.0]
MRA10.942376 (37.4)0.679343 (38.6)
MRA dose (mg/24h)175.325.0 [25.0, 25.0]75.525.0 [25.0, 25.0]
Digoxin10.614862 (13.1)0.427435 (13.3)
Platelet inhibitor10.644577 (39.2)0.580458 (39.1)
Oral anticoagulant10.652927 (46.6)0.599517 (48.4)
Statin10.552912 (46.5)0.4101529 (49.3)
Nitrate10.715034 (13.2)0.526719 (13.0)
SGLT2i191.72022 (21.3)94.92186 (20.9)
SGLT2i dose (mg/24h)198.210.0 [10.0, 10.0]98.910.0 [10.0, 10.0]
Sinus node inhibitor158.3248 (0.5)61.3473 (0.6)
Device therapy11.41.7
    No93068 (82.5)164078 (80.8)
    Pacemaker10685 (9.5)19200 (9.5)
    CRT-P2154 (1.9)4370 (2.2)
    CRT-D3369 (3.0)7741 (3.8)
    ICD3524 (3.1)7669 (3.8)
Device therapy CRT/ICD11.49047 (8.0)1.719780 (9.7)
Chest X-ray137.035.2
    No18770 (26.0)36050 (26.9)
    Normal17955 (24.9)32987 (24.6)
    Pulmonary congestion9713 (13.5)16557 (12.4)
    Cardiomegaly11934 (16.6)23395 (17.5)
    Pulmonary congestion & cardiomegaly13718 (19.0)24955 (18.6)
Diabetes110.317712 (17.3)9.734450 (18.5)
Diabetes128.628.6
    No65939 (80.8)118050 (80.0)
    Type I1311 (1.6)2244 (1.5)
    Type II14397 (17.6)27337 (18.5)
Hypertension12.363793 (57.1)2.1113641 (56.2)
Atrial fibrillation/flutter10.759692 (52.6)0.6106801 (52.0)
Lung disease12.120034 (17.9)2.035327 (17.4)
Valve disease13.522501 (20.4)3.540839 (20.5)
Dilated cardiomyopathy14.611420 (10.5)4.625229 (12.8)
Revascularization13.029922 (27.0)3.257913 (28.9)
Valve surgery12.17379 (6.6)2.313971 (6.9)
ECG rythm17.06.4
    Sinus53466 (50.3)97645 (50.5)
    Atrial fibrillation40427 (38.0)71468 (36.9)
    PM/Other12485 (11.7)24361 (12.6)
Follow-up referral HF nurse clinic19.655145 (53.3)7.0118717 (61.8)
Follow-up referral speciality18.05.8
    Hospital62428 (59.3)124411 (63.9)
    Primary care38790 (36.9)64273 (33.0)
    Other4034 (3.8)6012 (3.1)
Follow-up referral speciality Hospital18.062428 (59.3)5.8124411 (63.9)
QoL EQ-5D169.570.0 [50.0, 80.0]68.570.0 [50.0, 80.0]
QoL EQ-5D169.568.5
    0-251646 (4.7)2924 (4.5)
    26-508723 (25.0)15867 (24.4)
    51-7514062 (40.3)26745 (41.1)
    76-10010424 (29.9)19531 (30.0)
Fatigue161.560.2
    At rest2682 (6.1)4430 (5.4)
    At moderate effort12247 (27.8)22021 (26.8)
    At more than moderate effort21839 (49.6)42634 (51.8)
    Unaffected7239 (16.4)13191 (16.0)
Out of breath161.159.8
    At rest1491 (3.3)2357 (2.8)
    At moderate effort13459 (30.2)24267 (29.2)
    At more than moderate effort22848 (51.3)44385 (53.4)
    Unaffected6750 (15.2)12111 (14.6)
Mobilty160.959.8
    Bedridden579 (1.3)820 (1.0)
    Some problem20179 (45.2)35933 (43.2)
    No problem23931 (53.6)46384 (55.8)
Hygiene161.260.0
    Can't wash and clothe925 (2.1)1292 (1.6)
    Some problem5234 (11.8)8468 (10.2)
    No problem38230 (86.1)72892 (88.2)
Main activities161.460.2
    Can't do2276 (5.2)3616 (4.4)
    Some problem12052 (27.3)21732 (26.4)
    No problem29829 (67.6)56887 (69.2)
Pain162.761.4
    Severe2712 (6.4)4743 (6.0)
    Moderate19140 (44.9)35708 (44.8)
    None20780 (48.7)39256 (49.3)
Anxiety/Depression164.262.9
    Severe1835 (4.5)3155 (4.1)
    Moderate15017 (36.7)28028 (36.5)
    None24085 (58.8)45555 (59.4)
BMI (kg/m²)138.226.3 [23.3, 30.2]32.626.7 [23.6, 30.5]
BMI (kg/m²) ≥30138.218566 (26.3)32.539078 (28.0)
Age (years)10.00.0
    <7030727 (26.9)62624 (30.3)96349 (22.8)125509 (32.3)190209 (24.3)
    70-8039316 (34.4)75073 (36.3)129929 (30.7)148752 (38.3)254503 (32.5)
    >8044332 (38.8)68937 (33.4)196598 (46.5)114577 (29.5)337510 (43.1)
Previous HFH < 1 year120.066506 (58.1)0.0115625 (56.0)287370 (68.0)0 (0.0)0 (0.0)
Atrial fibrillation/flutter120.067696 (59.2)0.0120790 (58.5)186607 (44.1)26061 (6.7)51634 (6.6)
IHD120.061627 (53.9)0.0113161 (54.8)191730 (45.3)50542 (13.0)105655 (13.5)
Hypertension120.077441 (67.7)0.0137681 (66.6)218197 (51.6)83447 (21.5)148166 (18.9)
Diabetes120.031118 (27.2)0.057402 (27.8)96482 (22.8)31969 (8.2)57754 (7.4)
Valve disease120.030732 (26.9)0.055720 (27.0)64165 (15.2)7756 (2.0)13740 (1.8)
Country of birth30.00.0
    Sweden98473 (86.1)176223 (85.3)370296 (87.6)338660 (87.1)695921 (89.0)
    Europe12364 (10.8)23606 (11.4)42098 (10.0)37013 (9.5)66666 (8.5)
    Other3536 (3.1)6802 (3.3)10471 (2.5)13134 (3.4)19586 (2.5)
Children30.095795 (83.8)0.0172849 (83.6)350314 (82.8)329013 (84.6)654789 (83.7)
Marital status Single/widowed/divorced30.161993 (54.2)0.1108224 (52.4)246424 (58.4)183019 (47.1)415532 (53.2)
Family type Living alone30.157758 (50.5)0.199991 (48.4)232291 (55.0)168464 (43.4)391402 (50.1)
Education32.12.1
    Compulsory school50010 (44.7)88400 (43.7)206616 (51.1)145477 (38.1)345641 (46.0)
    Secondary school43213 (38.6)79798 (39.4)140319 (34.7)147189 (38.5)263179 (35.0)
    University18697 (16.7)34143 (16.9)57729 (14.3)89221 (23.4)142223 (18.9)
Disposable income (100 SEK)30.11534.0 [1226.0, 2041.0]0.11545.0 [1236.0, 2076.0]1365.0 [1055.0, 1783.0]1653.0 [1269.0, 2478.0]1408.0 [1061.0, 1963.0]
Duration of HF (days)20.0303.0 [14.0, 1736.0]0.0343.0 [18.0, 1883.0]0.0 [0.0, 101.0]
Time since last HF hospitalization (days)240.820.0 [0.0, 264.0]40.422.0 [0.0, 287.0]0.0 [0.0, 0.0]
Location20.00.0
    HF in-patient29379 (25.7)51246 (24.8)287370 (68.0)
    Other in-patient16270 (14.2)24942 (12.1)13696 (3.2)
    Out-patient68726 (60.1)130446 (63.1)121810 (28.8)
Hypertension20.067327 (58.9)0.0118776 (57.5)218197 (51.6)83447 (21.5)148166 (18.9)
Diabetes20.029925 (26.2)0.054888 (26.6)96482 (22.8)31969 (8.2)57754 (7.4)
Ischemic heart disease20.060454 (52.9)0.0110900 (53.7)190114 (45.0)50209 (12.9)105218 (13.5)
Myocardial infarction20.044249 (38.7)0.081357 (39.4)130249 (30.8)27019 (6.9)54342 (6.9)
Angina pectoris20.022181 (19.4)0.041455 (20.1)77036 (18.2)15463 (4.0)35088 (4.5)
PCI20.021899 (19.1)0.041645 (20.2)47489 (11.2)16445 (4.2)23714 (3.0)
CABG20.028938 (25.3)0.055861 (27.0)65972 (15.6)20000 (5.1)29752 (3.8)
Dilated cardiomyopathy20.09953 (8.7)0.022104 (10.7)13639 (3.2)0 (0.0)0 (0.0)
Peripheral artery disease20.010968 (9.6)0.018865 (9.1)34563 (8.2)10077 (2.6)19198 (2.5)
Atrial fibrillation/flutter20.062870 (55.0)0.0111846 (54.1)186607 (44.1)26061 (6.7)51634 (6.6)
Stroke20.018149 (15.9)0.030719 (14.9)70420 (16.7)33721 (8.7)77571 (9.9)
TIA20.04109 (3.6)0.07105 (3.4)15546 (3.7)8388 (2.2)17945 (2.3)
Stroke/TIA20.020666 (18.1)0.035136 (17.0)79946 (18.9)39439 (10.1)89741 (11.5)
Valvular disease20.023871 (20.9)0.042582 (20.6)64165 (15.2)7756 (2.0)13740 (1.8)
Renal failure20.019467 (17.0)0.032496 (15.7)49689 (11.8)7026 (1.8)11962 (1.5)
Hyperkalemia20.02500 (2.2)0.04333 (2.1)4706 (1.1)602 (0.2)1053 (0.1)
Hypokalemia20.03174 (2.8)0.05136 (2.5)9876 (2.3)2081 (0.5)4182 (0.5)
Dialysis20.01131 (1.0)0.01863 (0.9)4464 (1.1)647 (0.2)1036 (0.1)
COPD20.016169 (14.1)0.028419 (13.8)51011 (12.1)10675 (2.7)19835 (2.5)
Pneumonia/Flue/Respiratory infection20.042328 (37.0)0.073936 (35.8)151531 (35.8)36286 (9.3)72903 (9.3)
Liver disease20.02609 (2.3)0.04680 (2.3)7973 (1.9)2683 (0.7)4199 (0.5)
Obstructive sleep apnea20.04869 (4.3)0.09503 (4.6)10726 (2.5)5483 (1.4)7027 (0.9)
Dementia20.02998 (2.6)0.03838 (1.9)18772 (4.4)13962 (3.6)36467 (4.7)
Depression20.04464 (3.9)0.07701 (3.7)15492 (3.7)8931 (2.3)17266 (2.2)
Malignant cancer within 3 years20.015045 (13.2)0.025958 (12.6)54617 (12.9)43057 (11.1)79708 (10.2)
Muscoloskeletal/connective tissue diseases within 3 years20.037283 (32.6)0.066206 (32.0)124052 (29.3)77639 (20.0)137759 (17.6)
Alcohol abuse20.03654 (3.2)0.06566 (3.2)10900 (2.6)5618 (1.4)8427 (1.1)
Severe bleeding20.022922 (20.0)0.039016 (18.9)72037 (17.0)26950 (6.9)53017 (6.8)
Charlson Comorbidity Index20.03.0 [1.0, 4.0]0.03.0 [1.0, 4.0]3.0 [1.0, 4.0]0.0 [0.0, 2.0]0.0 [0.0, 2.0]
Charlson Comorbidity Index20.00.0
    0-129521 (25.8)55409 (26.8)115662 (27.4)276348 (71.1)569447 (72.8)
    2-342102 (36.8)77627 (37.6)171369 (40.5)80492 (20.7)157568 (20.1)
    4-734525 (30.2)59881 (29.0)112854 (26.7)26414 (6.8)46081 (5.9)
    ≥88227 (7.2)13717 (6.6)22991 (5.4)5584 (1.4)9126 (1.2)
Heart failure hospitalization20.031555 (27.6)0.077994 (37.7)145770 (34.5)0 (0.0)0 (0.0)
Number of heart failure hospitalizations20.00.0 [0.0, 1.0]0.00.0 [0.0, 1.0]0.0 [0.0, 1.0]0.0 [0.0, 0.0]0.0 [0.0, 0.0]
Any hospitalization20.079304 (69.3)0.0154397 (74.7)320292 (75.7)199583 (51.3)478972 (61.2)
CV hospitalization20.052581 (46.0)0.0112733 (54.6)226587 (53.6)67618 (17.4)172962 (22.1)
Non-CV hospitalization20.063308 (55.4)0.0123023 (59.5)261438 (61.8)177818 (45.7)429948 (55.0)
Stroke/TIA hospitalization20.08457 (7.4)0.016164 (7.8)40004 (9.5)28959 (7.4)78911 (10.1)
Myocardial infarction hospitalization20.06029 (5.3)0.012647 (6.1)34612 (8.2)10723 (2.8)29969 (3.8)
Ischemic heart disease hospitalization20.010683 (9.3)0.024304 (11.8)56005 (13.2)15725 (4.0)41744 (5.3)
Ventricular fibrillation/tachycardia hospitalization20.01321 (1.2)0.03953 (1.9)4785 (1.1)223 (0.1)524 (0.1)
Pneumonia/Flue/Respiratory infection hospitalization20.019445 (17.0)0.039431 (19.1)89403 (21.1)30443 (7.8)79891 (10.2)
Pneumonia hospitalization20.012959 (11.3)0.026420 (12.8)58778 (13.9)22892 (5.9)60174 (7.7)
Renal failure hospitalization20.06471 (5.7)0.013711 (6.6)25296 (6.0)4574 (1.2)10094 (1.3)
Malignant cancer hospitalization20.08037 (7.0)0.014449 (7.0)35025 (8.3)37816 (9.7)91528 (11.7)
Severe bleeding hospitalization20.016292 (14.2)0.032475 (15.7)64957 (15.4)33183 (8.5)81045 (10.4)
Hyperkalemia hospitalization20.0683 (0.6)0.01715 (0.8)2825 (0.7)235 (0.1)532 (0.1)
Hypokalemia hospitalization20.0322 (0.3)0.0816 (0.4)1345 (0.3)542 (0.1)1195 (0.2)
Syncope hospitalization20.02691 (2.4)0.06094 (2.9)12114 (2.9)6400 (1.6)17134 (2.2)
Trauma hospitalization20.014517 (12.7)0.027837 (13.5)65663 (15.5)44297 (11.4)130595 (16.7)
Coronary revascularization20.03708 (3.2)0.08998 (4.4)18924 (4.5)8890 (2.3)17394 (2.2)
Death20.064876 (56.7)0.0112286 (54.3)300917 (71.2)127556 (32.8)406620 (52.0)
CV death20.038524 (33.7)0.068541 (33.2)178361 (42.2)40123 (10.3)145478 (18.6)
Non-CV death20.026352 (23.0)0.043745 (21.2)122556 (29.0)87433 (22.5)261142 (33.4)
Hospitalization or death Sudden cardiac death20.059 (0.1)0.0110 (0.1)346 (0.1)99 (0.0)542 (0.1)
Composite CVD/HFH20.053843 (47.1)0.0106812 (51.7)247007 (58.4)40123 (10.3)145478 (18.6)
Composite Death/HFH20.072271 (63.2)0.0132076 (63.9)329180 (77.8)127556 (32.8)406620 (52.0)
Note:
Patients have different follow-up times, this means that outcomes can not be interpreted directly from the table.
Categorical variables are presented with n (%) and continuous variables with median [q1-q3].
1 Source: SwedeHF
2 Source: NPR
3 Source: SCB
+ + +
+
+ + +
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Variable description

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+ +  Download Variable Description + +

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+ + + + + \ No newline at end of file diff --git a/docs/variabledescription/meta_variables.xlsx b/docs/variabledescription/meta_variables.xlsx new file mode 100644 index 0000000..eef1e5a Binary files /dev/null and b/docs/variabledescription/meta_variables.xlsx differ diff --git a/docs/versions/index.html b/docs/versions/index.html new file mode 100644 index 0000000..82f556c --- /dev/null +++ b/docs/versions/index.html @@ -0,0 +1,441 @@ + + + + + + + + + +SHFDB4 - Versions + + + + + + + + + + + + + + + + + + + + + + + + + + +
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Versions

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4.0.0

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  • This is the first version. Consists only of SwedeHF.
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4.0.1

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  • Changed name from kidney to renal (sos_com_kidney, sos_out_hospkidney, sos_outtime_hospkidney).

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  • Changed ICD codes for HF (R57 to R570), affects variables sos_out_counthosphf, sos_outtime_hospcv, sos_out_hospcv, sos_outtime_hosphf, sos_out_hosphf, sos_out_deathcv, sos_out_deathnoncv, sos_out_deathcvhosphf, sos_out_deathhosphf, sos_timeprevhosphf, sos_durationhf, sos_out_hospnoncv, sos_outtime_hospnoncv, sos_location (all minor changes n < 100).

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  • Changed ICD codes for sos_com_dementia (added R54) (minor change n = 35).

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  • Changed ICD codes for sos_com_valvular (added Q230-3, Q235-9) (minor change n = 11).

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  • Changed ICD codes for sos_out_hosprespiratory (added so all J) (major change n = 11282).

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  • Added sos_com_respiratory.

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4.1.0

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  • Added HF population from NPR and HF-free controls.

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  • Added categorical variable for Charlson Comorbidity Index and QoL.

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  • Added shf_sos_prevhfh1yr.

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  • Changed so levels of shf_potassium_cat starts with capital letter.

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4.1.1

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  • shf_age_cat 3 levels (previously 2)

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  • Removed shf_eforg, shf_bmiimp, shf_bmiimp_cat

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  • Added shf_fatigue, shf_outofbreath, shf_mobility, shf_hygiene, shf_activities, shf_pain, shf_anxiety

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  • Excluded 3 patients with fu time = 0

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  • Added data on discharge and admission labs in rsdatafull

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  • shf_durationhf changed names of levels

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  • 1-4 values changed in shf_durationhf, shf_primaryetiology, shf_diabetes, shf_sos_com_diabetes, shf_diabetestype, shf_af, shf_valvedisease, shf_lungdisease, shf_dcm due to different order of selection

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  • Approx 100 changes in shf_height, shf_bmi, shf_bmi_cat due to imputation of bmi prior to cleaning outliers

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  • sos_deathcause set to missing for patients with sos_out_death = No (patients who died > 2021-12-31)

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  • Changes in number of patients for NPR HF, controls (NPR pop and SwedeHF) in rsdatafull due to SweeHF controls now also for patients died in-hospital, and linked hospitalizations used for defining the population and controls.

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+ + + + + \ No newline at end of file diff --git a/html/styles.scss b/html/styles.scss new file mode 100644 index 0000000..714d172 --- /dev/null +++ b/html/styles.scss @@ -0,0 +1,120 @@ +/*-- scss:defaults --*/ + +/* From https://github.com/andrewheiss/ath-quarto/blob/main/html/ath.scss */ + +$white: #ffffff !default; +$gray-100: #f8f9fa !default; +$gray-200: #e9ecef !default; +$gray-300: #dee2e6 !default; +$gray-400: #ced4da !default; +$gray-500: #adb5bd !default; +$gray-600: #868e96 !default; +$gray-700: #495057 !default; +$gray-800: #373a3c !default; +$gray-900: #212529 !default; +$black: #000000 !default; + +$blue: #2780e3 !default; +$indigo: #6610f2 !default; +$purple: #170C3A !default; +$pink: #A52C60 !default; +$red: #CF4446 !default; +$orange: #EE6A24 !default; +$light-orange: #FB9E07 !default; +$yellow: #F6D645 !default; +$green: #118230 !default; +$teal: #068194 !default; +$cyan: #3093CF !default; + +$primary: $teal!default; +$secondary: $gray-700 !default; +$success: $green !default; +$info: $cyan !default; +$warning: $orange !default; +$danger: $red !default; +$light: $gray-400 !default; +$dark: $black !default; + + + +// Links +$link-color: $primary !default; +$link-decoration: none !default; +$link-hover-color: $red !default; +$link-hover-decoration: underline !default; + +// Footer +$footer-bg: $gray-900 !default; +$footer-fg: $gray-300 !default; + +// Inline code +$code-bg: $gray-200 !default; +$code-color: $gray-900 !default; + +// TOC +$toc-color: $orange; +$toc-font-size: 1em; + +// Code copy +$btn-code-copy-color-active: $orange !default; + + +/*-- scss:rules --*/ + + +.nav-footer { + align-items: flex-start; // Align all flex items to the top + flex-wrap: wrap; + border: 0 !important; + min-height: 3em; + //font-family: $footer-font-family; + + a { + color: $primary; + } + + .faux-block { + display: block; + padding-bottom: 0.4em; + } + + // In the default Quarto template, .nav-footer-center has position: absolute + // turned on, which makes the div not be a flex item + // This changes that so that it *is* a flex item + .nav-footer-center { + text-align: center; + position: inherit; + margin-top: 0; + + @media (max-width: map-get($grid-breakpoints, md)) { + margin-top: 0.5em; + margin-bottom: 1.5em; + } + } + + // When the screen is medium or smaller, make each footer chunk be 100% width + // and centered; otherwise make them be 33% width and left/right/centerd + .nav-footer-left, + .nav-footer-right, + .nav-footer-center { + text-align: center; + width: 100%; + min-height: 2em; + } + + @media (min-width: map-get($grid-breakpoints, md)) { + .nav-footer-left { + text-align: left; + } + + .nav-footer-right { + text-align: right; + } + + .nav-footer-left, + .nav-footer-right, + .nav-footer-center { + flex: 1 1 33%; + } + } +} \ No newline at end of file diff --git a/img/logo.jpg b/img/logo.jpg new file mode 100644 index 0000000..aad8dae Binary files /dev/null and b/img/logo.jpg differ diff --git a/index.qmd b/index.qmd new file mode 100644 index 0000000..c621700 --- /dev/null +++ b/index.qmd @@ -0,0 +1,35 @@ +--- +about: + template: marquee + id: about-block + image: "img/logo.jpg" + links: + - icon: github + text: Github + href: https://github.com/KIHeartFailure + - icon: envelope + text: Contact + href: "mailto:lina.benson@ki.se" +--- + +::: {#about-block} +::: + +# SwedeHF database 4 (SHFDB4) + +A Heart Failure cohort from Sweden 2000 - 2021. The population consists of + +1) patients recorded in the Swedish Heart Failure Registry (SwedeHF), + +2) patients recorded in the National Patient Register with a ICD-10 code in main position for HF and + +3) gender, year of birth and county of residence matched HF-free controls. + + +Please feel free to [contact me](mailto:lina.benson@ki.se) if you have any questions. + +```{=html} + +``` \ No newline at end of file diff --git a/population/index.qmd b/population/index.qmd new file mode 100644 index 0000000..e85d5f9 --- /dev/null +++ b/population/index.qmd @@ -0,0 +1,57 @@ +--- +title: Population +--- + +```{r setup, include=FALSE} +knitr::opts_chunk$set( + echo = FALSE, include = TRUE, comment = "", + warning = FALSE, message = FALSE +) +options(knitr.kable.NA = "") +``` + +```{r loadlibsdata} +library(tableone) +library(dplyr) +library(tidyr) +library(knitr) +library(kableExtra) + +load(file = here::here("../dm/data/data_for_webb.RData")) +``` + +## Patients registered in SwedeHF + +All patients recorded in SwedeHF are included. + +---- + +## Patients with HF from the National Patient Register + +Patients with an ICD-10 code for HF in main position in the National Patient Register (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761) starting from 2000-01-01 with no previous ICD-9/10 code for HF (I110 I130 I132 I255 I420 I423 1425 I426 I427 I428 I429 I43 I50 J81 K761 ICD-9: 414W 425E 425F 425G 425H 425W 425X 428) since 1987. + +---- + +## HF-free controls + +For each post in SwedeHF or the first date in the National Patient Register a set of controls was chosen by Statistics Sweden in a ratio of 2:1. Since a person can have more than one registered post in SwedeHF a patient can have more than 2 controls in total, up to 2 for each posts. + +Eligible controls were persons without re-used Swedish personal identity numbers (PINs) and free of HF, defined either in the National Patient registry (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761, R570, ICD-9: 414W, 425E-H, 425W, 425X, 428) or SwedeHF, at the end of the year of the index date for the case and matched by gender, year of birth and county of residence at index. For posts with age ≥ 90 years, controls were only matched by gender and year of birth due to the smaller available number of controls. + +The selection of controls was performed without replacement. + +A control was allowed to become a case after the year of the index date for the case. + +A full set of controls (n = 2) was not found for all cases: + +```{r ncon} +kable(ncontrols) +``` + +---- + +## Inclusion/exclusion criteria + +```{r flow} +kable(flow) +``` \ No newline at end of file diff --git a/statistics/index.qmd b/statistics/index.qmd new file mode 100644 index 0000000..b72afa7 --- /dev/null +++ b/statistics/index.qmd @@ -0,0 +1,149 @@ +--- +title: Statistics +--- + +## Over time - interactive + +Descriptive statistics over time can be found: [https://swedehf.shinyapps.io/deskstatshfdb4](https://swedehf.shinyapps.io/deskstatshfdb4) + +---- + +## Descriptive statistics + +```{r setup, include=FALSE} +knitr::opts_chunk$set( + echo = FALSE, include = TRUE, comment = "", + warning = FALSE, message = FALSE +) +options(knitr.kable.NA = "") +``` + +```{r loadlibsdata} +library(tableone) +library(dplyr) +library(tidyr) +library(knitr) +library(kableExtra) +library(openxlsx) +library(stringr) +library(hfmisc) + +load(file = here::here("../dm/data/rsdata_for_webb.RData")) + +meta <- read.xlsx(here::here("../dm/metadata/meta_variables.xlsx")) +rsdata <- rsdatafull +``` + +```{r tab} +tabvars <- names(rsdata)[str_detect(names(rsdata), + "lopnr|casecontrol|shf_source|sos_deathcause|scb_region|shf_centre|sos_outtime_|dtm|shf_aceisub|shf_arbsub|shf_arnidose|shf_bblsub|shf_mrasub|shf_sglt2sub", + negate = T +)] + +tabfunc <- function(data) { + # median + tabmed <- print( + CreateTableOne( + data = data, + vars = tabvars, + strata = "casecontrol" + ), + varLabels = TRUE, missing = TRUE, printToggle = FALSE, test = FALSE, + catDigits = 1, contDigits = 1, + nonnormal = tabvars, + explain = FALSE, + noSpaces = TRUE + ) + tabmed <- as_tibble(cbind(var = rownames(tabmed), tabmed)) + return(tabmed) +} + +# Posts +tab <- tabfunc(data = rsdata) +tabcasesswedehf <- tabfunc(data = rsdata %>% filter(casecontrol == "Case SwedeHF")) + +# Unique individuals +rsdatau <- rsdata %>% + filter(casecontrol == "Case SwedeHF") %>% + group_by(lopnr) %>% + arrange(shf_indexdtm) %>% + slice(n()) %>% + ungroup() + +## Cases +tabucases <- tabfunc(rsdatau) + +taball <- bind_cols( + tabucases %>% select(var, Missing, "Case SwedeHF"), + tabcasesswedehf %>% select(Missing, "Case SwedeHF"), + tab %>% select(-var, -Missing, -"Case SwedeHF") +) + +taball <- taball %>% + # remove = Yes + mutate(across(everything(), str_replace_all, fixed(" = Yes"), "")) %>% + mutate(across(everything(), str_replace_all, fixed("0 (NaN)"), "")) %>% + mutate(across(everything(), str_replace_all, fixed("NA [NA, NA]"), "")) %>% + # to get labs and units in place + mutate( + var_tmp = str_split(var, " = ", simplify = TRUE)[, 1], + val_tmp = str_split(var, " = ", simplify = TRUE)[, 2] + ) + +taball <- left_join(taball, + meta %>% + select(variable, label, unit), + by = c("var_tmp" = "variable") +) %>% + mutate( + Variable = coalesce(label, var_tmp), + Variable = if_else(!is.na(unit), + paste0(Variable, " (", unit, ")"), + Variable + ), + Variable = if_else(val_tmp != "", + paste0(Variable, " ", val_tmp), + Variable + ) + ) + +# footnotes +taball <- taball %>% + mutate( + footnote1 = if_else(str_detect(var_tmp, "^shf_"), footnote_marker_number(1), ""), + footnote2 = if_else(str_detect(var_tmp, "sos_"), footnote_marker_number(2), ""), + footnote3 = if_else(str_detect(var_tmp, "^scb_"), footnote_marker_number(3), "") + ) %>% + unite(footnote, starts_with("footnote"), sep = "") %>% + mutate( + # so no probs + # Variable = sanitize_text(Variable), + Variable = paste0(Variable, footnote), + # fix get/let + Variable = str_replace(Variable, ">=", "≥"), + Variable = str_replace(Variable, "<=", "≤"), + + # space in output + Variable = sub(" ", "   ", Variable) + # Variable <- str_replace(Variable, fixed(" "), "    ") + # Variable = sub(" ", " ", Variable) + ) %>% + select(Variable, Missing...2:"Control NPR") + +colnames(taball) <- c("Variable", rep(c("% missing", "SwedeHF"), 2), "Case NPR", "Control SwedeHF", "Control NPR") + +knitr::kable(taball, row.names = F, escape = FALSE) %>% + add_header_above(c(" " = 1, "Patients (last post)" = 2, "Posts" = 2, " " = 1, " " = 1, " " = 1)) %>% + footnote( + general = c( + "Patients have different follow-up times, this means that outcomes can not be interpreted directly from the table.", + "Categorical variables are presented with n (%) and continuous variables with median [q1-q3]." + ), + number = c( + "Source: SwedeHF", + "Source: NPR", + "Source: SCB" + ), escape = FALSE, + threeparttable = T + ) +``` diff --git a/variabledescription/index.qmd b/variabledescription/index.qmd new file mode 100644 index 0000000..a96126d --- /dev/null +++ b/variabledescription/index.qmd @@ -0,0 +1,17 @@ +--- +layout: page +title: Variable description +execute: + freeze: true # never re-render during project render +engine: knitr +meta_variables: + xlsx: "meta_variables.xlsx" +--- + +```{=html} +

+ +  Download Variable Description + +

+``` \ No newline at end of file diff --git a/variabledescription/meta_variables.xlsx b/variabledescription/meta_variables.xlsx new file mode 100644 index 0000000..eef1e5a Binary files /dev/null and b/variabledescription/meta_variables.xlsx differ diff --git a/versions/index.qmd b/versions/index.qmd new file mode 100644 index 0000000..371512d --- /dev/null +++ b/versions/index.qmd @@ -0,0 +1,59 @@ +--- +title: Versions +--- + +## 4.0.0 + +- This is the first version. Consists only of SwedeHF. + +---- + +## 4.0.1 + +- Changed name from kidney to renal (sos_com_kidney, sos_out_hospkidney, sos_outtime_hospkidney). + +- Changed ICD codes for HF (R57 to R570), affects variables sos_out_counthosphf, sos_outtime_hospcv, sos_out_hospcv, sos_outtime_hosphf, sos_out_hosphf, sos_out_deathcv, sos_out_deathnoncv, sos_out_deathcvhosphf, sos_out_deathhosphf, sos_timeprevhosphf, sos_durationhf, sos_out_hospnoncv, sos_outtime_hospnoncv, sos_location (all minor changes n < 100). + +- Changed ICD codes for sos_com_dementia (added R54) (minor change n = 35). + +- Changed ICD codes for sos_com_valvular (added Q230-3, Q235-9) (minor change n = 11). + +- Changed ICD codes for sos_out_hosprespiratory (added so all J) (major change n = 11282). + +- Added sos_com_respiratory. + +---- + +## 4.1.0 + +- Added HF population from NPR and HF-free controls. + +- Added categorical variable for Charlson Comorbidity Index and QoL. + +- Added shf_sos_prevhfh1yr. + +- Changed so levels of shf_potassium_cat starts with capital letter. + +---- + +## 4.1.1 + +- shf_age_cat 3 levels (previously 2) + +- Removed shf_eforg, shf_bmiimp, shf_bmiimp_cat + +- Added shf_fatigue, shf_outofbreath, shf_mobility, shf_hygiene, shf_activities, shf_pain, shf_anxiety + +- Excluded 3 patients with fu time = 0 + +- Added data on discharge and admission labs in rsdatafull + +- shf_durationhf changed names of levels + +- 1-4 values changed in shf_durationhf, shf_primaryetiology, shf_diabetes, shf_sos_com_diabetes, shf_diabetestype, shf_af, shf_valvedisease, shf_lungdisease, shf_dcm due to different order of selection + +- Approx 100 changes in shf_height, shf_bmi, shf_bmi_cat due to imputation of bmi prior to cleaning outliers + +- sos_deathcause set to missing for patients with sos_out_death = No (patients who died > 2021-12-31) + +- Changes in number of patients for NPR HF, controls (NPR pop and SwedeHF) in rsdatafull due to SweeHF controls now also for patients died in-hospital, and linked hospitalizations used for defining the population and controls. \ No newline at end of file diff --git a/webb.Rproj b/webb.Rproj new file mode 100644 index 0000000..8e3c2eb --- /dev/null +++ b/webb.Rproj @@ -0,0 +1,13 @@ +Version: 1.0 + +RestoreWorkspace: Default +SaveWorkspace: Default +AlwaysSaveHistory: Default + +EnableCodeIndexing: Yes +UseSpacesForTab: Yes +NumSpacesForTab: 2 +Encoding: UTF-8 + +RnwWeave: Sweave +LaTeX: pdfLaTeX