diff --git a/base/loading.jl b/base/loading.jl
index b85828e37a8b3..79d8674c940ce 100644
--- a/base/loading.jl
+++ b/base/loading.jl
@@ -746,11 +746,19 @@ function stale_cachefile(modpath::String, cachefile::String)
         modules, files, required_modules = parse_cache_header(io)
 
         # Check if transitive dependencies can be fullfilled
-        for mod in keys(required_modules)
+        for (mod, uuid) in required_modules
             if mod == :Main || mod == :Core || mod == :Base
                 continue
             # Module is already loaded
-            elseif isdefined(Main, mod)
+            elseif isbindingresolved(Main, mod)
+                current_uuid = module_uuid(getfield(Main, mod))
+                # Depends on the assumption that uuid monotonically increase
+                if current_uuid > uuid
+                    # Module is newer, reject cache
+                    return true
+                elseif current_uuid < uuid
+                    warn("The currently loaded module $mod is older than the dependency for $cachefile and will be replaced.")
+                end
                 continue
             end
             name = string(mod)
diff --git a/src/dump.c b/src/dump.c
index 7a32a63715d83..beeac990bc568 100644
--- a/src/dump.c
+++ b/src/dump.c
@@ -2282,8 +2282,12 @@ static jl_value_t *read_verify_mod_list(ios_t *s, arraylist_t *dependent_worlds)
         uint64_t uuid = read_uint64(s);
         jl_sym_t *sym = jl_symbol(name);
         jl_module_t *m = NULL;
-        if (jl_binding_resolved_p(jl_main_module, sym))
+        if (jl_binding_resolved_p(jl_main_module, sym)) {
             m = (jl_module_t*)jl_get_global(jl_main_module, sym);
+            // Potentially two modules with the same name.
+            if (m && jl_is_module(m) && m->uuid != uuid)
+                m = NULL;
+        }
         if (!m) {
             static jl_value_t *require_func = NULL;
             if (!require_func)