diff --git a/base/compiler/abstractinterpretation.jl b/base/compiler/abstractinterpretation.jl
index dc4663a877d9a..3a026bf3b482c 100644
--- a/base/compiler/abstractinterpretation.jl
+++ b/base/compiler/abstractinterpretation.jl
@@ -554,7 +554,7 @@ function maybe_get_const_prop_profitable(interp::AbstractInterpreter, result::Me
         return nothing
     end
     mi = mi::MethodInstance
-    if !force && !const_prop_methodinstance_heuristic(interp, method, mi)
+    if !force && !const_prop_methodinstance_heuristic(interp, match, mi)
         add_remark!(interp, sv, "[constprop] Disabled by method instance heuristic")
         return nothing
     end
@@ -656,7 +656,8 @@ end
 # This is a heuristic to avoid trying to const prop through complicated functions
 # where we would spend a lot of time, but are probably unlikely to get an improved
 # result anyway.
-function const_prop_methodinstance_heuristic(interp::AbstractInterpreter, method::Method, mi::MethodInstance)
+function const_prop_methodinstance_heuristic(interp::AbstractInterpreter, match::MethodMatch, mi::MethodInstance)
+    method = match.method
     if method.is_for_opaque_closure
         # Not inlining an opaque closure can be very expensive, so be generous
         # with the const-prop-ability. It is quite possible that we can't infer
@@ -674,7 +675,8 @@ function const_prop_methodinstance_heuristic(interp::AbstractInterpreter, method
     if isdefined(code, :inferred) && !cache_inlineable
         cache_inf = code.inferred
         if !(cache_inf === nothing)
-            cache_inlineable = inlining_policy(interp)(cache_inf) !== nothing
+            # TODO maybe we want to respect callsite `@inline`/`@noinline` annotations here ?
+            cache_inlineable = inlining_policy(interp)(cache_inf, nothing, match) !== nothing
         end
     end
     if !cache_inlineable
@@ -1821,7 +1823,8 @@ function typeinf_local(interp::AbstractInterpreter, frame::InferenceState)
                     if isa(fname, SlotNumber)
                         changes = StateUpdate(fname, VarState(Any, false), changes, false)
                     end
-                elseif hd === :inbounds || hd === :meta || hd === :loopinfo || hd === :code_coverage_effect
+                elseif hd === :code_coverage_effect ||
+                       (hd !== :boundscheck && hd !== nothing && is_meta_expr_head(hd)) # :boundscheck can be narrowed to Bool
                     # these do not generate code
                 else
                     t = abstract_eval_statement(interp, stmt, changes, frame)
diff --git a/base/compiler/optimize.jl b/base/compiler/optimize.jl
index 6d059247a43ea..7298350b638a7 100644
--- a/base/compiler/optimize.jl
+++ b/base/compiler/optimize.jl
@@ -28,14 +28,20 @@ struct InliningState{S <: Union{EdgeTracker, Nothing}, T, P}
     policy::P
 end
 
-function default_inlining_policy(@nospecialize(src))
+function default_inlining_policy(@nospecialize(src), stmt_flag::Union{Nothing,UInt8}, match::Union{MethodMatch,InferenceResult})
     if isa(src, CodeInfo) || isa(src, Vector{UInt8})
         src_inferred = ccall(:jl_ir_flag_inferred, Bool, (Any,), src)
-        src_inlineable = ccall(:jl_ir_flag_inlineable, Bool, (Any,), src)
+        src_inlineable = is_stmt_inline(stmt_flag) || ccall(:jl_ir_flag_inlineable, Bool, (Any,), src)
         return src_inferred && src_inlineable ? src : nothing
-    end
-    if isa(src, OptimizationState) && isdefined(src, :ir)
-        return src.src.inlineable ? src.ir : nothing
+    elseif isa(src, OptimizationState) && isdefined(src, :ir)
+        return (is_stmt_inline(stmt_flag) || src.src.inlineable) ? src.ir : nothing
+    elseif src === nothing && is_stmt_inline(stmt_flag) && isa(match, MethodMatch)
+        # when the source isn't available at this moment, try to re-infer and inline it
+        # HACK in order to avoid cycles here, we disable inlining and makes sure the following inference never comes here
+        # TODO sort out `AbstractInterpreter` interface to handle this well, and also inference should try to keep the source if the statement will be inlined
+        interp = NativeInterpreter(; opt_params = OptimizationParams(; inlining = false))
+        src, rt = typeinf_code(interp, match.method, match.spec_types, match.sparams, true)
+        return src
     end
     return nothing
 end
@@ -134,6 +140,10 @@ const SLOT_USEDUNDEF    = 32 # slot has uses that might raise UndefVarError
 # This statement was marked as @inbounds by the user. If replaced by inlining,
 # any contained boundschecks may be removed
 const IR_FLAG_INBOUNDS       = 0x01
+# This statement was marked as @inline by the user
+const IR_FLAG_INLINE         = 0x01 << 1
+# This statement was marked as @noinline by the user
+const IR_FLAG_NOINLINE       = 0x01 << 2
 # This statement may be removed if its result is unused. In particular it must
 # thus be both pure and effect free.
 const IR_FLAG_EFFECT_FREE    = 0x01 << 4
@@ -179,6 +189,11 @@ function isinlineable(m::Method, me::OptimizationState, params::OptimizationPara
     return inlineable
 end
 
+is_stmt_inline(stmt_flag::UInt8)   = stmt_flag & IR_FLAG_INLINE != 0
+is_stmt_inline(::Nothing)          = false
+is_stmt_noinline(stmt_flag::UInt8) = stmt_flag & IR_FLAG_NOINLINE != 0
+is_stmt_noinline(::Nothing)        = false # not used for now
+
 # These affect control flow within the function (so may not be removed
 # if there is no usage within the function), but don't affect the purity
 # of the function as a whole.
@@ -366,6 +381,7 @@ function convert_to_ircode(ci::CodeInfo, code::Vector{Any}, coverage::Bool, narg
     renumber_ir_elements!(code, changemap, labelmap)
 
     inbounds_depth = 0 # Number of stacked inbounds
+    inline_flags = BitVector()
     meta = Any[]
     flags = fill(0x00, length(code))
     for i = 1:length(code)
@@ -380,16 +396,38 @@ function convert_to_ircode(ci::CodeInfo, code::Vector{Any}, coverage::Bool, narg
                 inbounds_depth -= 1
             end
             stmt = nothing
+        elseif isexpr(stmt, :inline)
+            if stmt.args[1]::Bool
+                push!(inline_flags, true)
+            else
+                pop!(inline_flags)
+            end
+            stmt = nothing
+        elseif isexpr(stmt, :noinline)
+            if stmt.args[1]::Bool
+                push!(inline_flags, false)
+            else
+                pop!(inline_flags)
+            end
+            stmt = nothing
         else
             stmt = normalize(stmt, meta)
         end
         code[i] = stmt
-        if !(stmt === nothing)
+        if stmt !== nothing
             if inbounds_depth > 0
                 flags[i] |= IR_FLAG_INBOUNDS
             end
+            if !isempty(inline_flags)
+                if last(inline_flags)
+                    flags[i] |= IR_FLAG_INLINE
+                else
+                    flags[i] |= IR_FLAG_NOINLINE
+                end
+            end
         end
     end
+    @assert isempty(inline_flags) "malformed meta flags"
     strip_trailing_junk!(ci, code, stmtinfo, flags)
     cfg = compute_basic_blocks(code)
     types = Any[]
diff --git a/base/compiler/ssair/inlining.jl b/base/compiler/ssair/inlining.jl
index b9eb382ffaa7e..6d47e3e7df252 100644
--- a/base/compiler/ssair/inlining.jl
+++ b/base/compiler/ssair/inlining.jl
@@ -600,6 +600,7 @@ function rewrite_apply_exprargs!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::
         argexprs::Vector{Any}, atypes::Vector{Any}, arginfos::Vector{Any},
         arg_start::Int, istate::InliningState)
 
+    flag = ir.stmts[idx][:flag]
     new_argexprs = Any[argexprs[arg_start]]
     new_atypes = Any[atypes[arg_start]]
     # loop over original arguments and flatten any known iterators
@@ -655,8 +656,9 @@ function rewrite_apply_exprargs!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::
                 info = call.info
                 handled = false
                 if isa(info, ConstCallInfo)
-                    if maybe_handle_const_call!(ir, state1.id, new_stmt, info, new_sig,
-                        call.rt, istate, false, todo)
+                    if !is_stmt_noinline(flag) && maybe_handle_const_call!(
+                        ir, state1.id, new_stmt, info, new_sig,call.rt, istate, flag, false, todo)
+
                         handled = true
                     else
                         info = info.call
@@ -667,7 +669,7 @@ function rewrite_apply_exprargs!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::
                         MethodMatchInfo[info] : info.matches
                     # See if we can inline this call to `iterate`
                     analyze_single_call!(ir, todo, state1.id, new_stmt,
-                        new_sig, call.rt, info, istate)
+                        new_sig, call.rt, info, istate, flag)
                 end
                 if i != length(thisarginfo.each)
                     valT = getfield_tfunc(call.rt, Const(1))
@@ -716,16 +718,16 @@ function compileable_specialization(et::Union{EdgeTracker, Nothing}, result::Inf
     return mi
 end
 
-function resolve_todo(todo::InliningTodo, state::InliningState)
-    spec = todo.spec::DelayedInliningSpec
+function resolve_todo(todo::InliningTodo, state::InliningState, flag::UInt8)
+    (; match) = todo.spec::DelayedInliningSpec
 
     #XXX: update_valid_age!(min_valid[1], max_valid[1], sv)
     isconst, src = false, nothing
-    if isa(spec.match, InferenceResult)
-        let inferred_src = spec.match.src
+    if isa(match, InferenceResult)
+        let inferred_src = match.src
             if isa(inferred_src, Const)
                 if !is_inlineable_constant(inferred_src.val)
-                    return compileable_specialization(state.et, spec.match)
+                    return compileable_specialization(state.et, match)
                 end
                 isconst, src = true, quoted(inferred_src.val)
             else
@@ -753,12 +755,10 @@ function resolve_todo(todo::InliningTodo, state::InliningState)
         return ConstantCase(src)
     end
 
-    if src !== nothing
-        src = state.policy(src)
-    end
+    src = state.policy(src, flag, match)
 
     if src === nothing
-        return compileable_specialization(et, spec.match)
+        return compileable_specialization(et, match)
     end
 
     if isa(src, IRCode)
@@ -769,17 +769,9 @@ function resolve_todo(todo::InliningTodo, state::InliningState)
     return InliningTodo(todo.mi, src)
 end
 
-function resolve_todo(todo::UnionSplit, state::InliningState)
+function resolve_todo(todo::UnionSplit, state::InliningState, flag::UInt8)
     UnionSplit(todo.fully_covered, todo.atype,
-        Pair{Any,Any}[sig=>resolve_todo(item, state) for (sig, item) in todo.cases])
-end
-
-function resolve_todo!(todo::Vector{Pair{Int, Any}}, state::InliningState)
-    for i = 1:length(todo)
-        idx, item = todo[i]
-        todo[i] = idx=>resolve_todo(item, state)
-    end
-    todo
+        Pair{Any,Any}[sig=>resolve_todo(item, state, flag) for (sig, item) in todo.cases])
 end
 
 function validate_sparams(sparams::SimpleVector)
@@ -790,7 +782,7 @@ function validate_sparams(sparams::SimpleVector)
 end
 
 function analyze_method!(match::MethodMatch, atypes::Vector{Any},
-                         state::InliningState, @nospecialize(stmttyp))
+                         state::InliningState, @nospecialize(stmttyp), flag::UInt8)
     method = match.method
     methsig = method.sig
 
@@ -806,11 +798,9 @@ function analyze_method!(match::MethodMatch, atypes::Vector{Any},
     end
 
     # Bail out if any static parameters are left as TypeVar
-    ok = true
     validate_sparams(match.sparams) || return nothing
 
-
-    if !state.params.inlining
+    if !state.params.inlining || is_stmt_noinline(flag)
         return compileable_specialization(state.et, match)
     end
 
@@ -824,7 +814,7 @@ function analyze_method!(match::MethodMatch, atypes::Vector{Any},
     # If we don't have caches here, delay resolving this MethodInstance
     # until the batch inlining step (or an external post-processing pass)
     state.mi_cache === nothing && return todo
-    return resolve_todo(todo, state)
+    return resolve_todo(todo, state, flag)
 end
 
 function InliningTodo(mi::MethodInstance, ir::IRCode)
@@ -1050,7 +1040,7 @@ is_builtin(s::Signature) =
     s.ft ⊑ Builtin
 
 function inline_invoke!(ir::IRCode, idx::Int, sig::Signature, info::InvokeCallInfo,
-        state::InliningState, todo::Vector{Pair{Int, Any}})
+        state::InliningState, todo::Vector{Pair{Int, Any}}, flag::UInt8)
     stmt = ir.stmts[idx][:inst]
     calltype = ir.stmts[idx][:type]
 
@@ -1064,7 +1054,7 @@ function inline_invoke!(ir::IRCode, idx::Int, sig::Signature, info::InvokeCallIn
     atypes = atypes[4:end]
     pushfirst!(atypes, atype0)
 
-    result = analyze_method!(info.match, atypes, state, calltype)
+    result = analyze_method!(info.match, atypes, state, calltype, flag)
     handle_single_case!(ir, stmt, idx, result, true, todo)
     return nothing
 end
@@ -1159,7 +1149,7 @@ end
 
 function analyze_single_call!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::Int, @nospecialize(stmt),
         sig::Signature, @nospecialize(calltype), infos::Vector{MethodMatchInfo},
-        state::InliningState)
+        state::InliningState, flag::UInt8)
     cases = Pair{Any, Any}[]
     signature_union = Union{}
     only_method = nothing  # keep track of whether there is one matching method
@@ -1192,7 +1182,7 @@ function analyze_single_call!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::Int
                 fully_covered = false
                 continue
             end
-            case = analyze_method!(match, sig.atypes, state, calltype)
+            case = analyze_method!(match, sig.atypes, state, calltype, flag)
             if case === nothing
                 fully_covered = false
                 continue
@@ -1219,7 +1209,7 @@ function analyze_single_call!(ir::IRCode, todo::Vector{Pair{Int, Any}}, idx::Int
             match = meth[1]
         end
         fully_covered = true
-        case = analyze_method!(match, sig.atypes, state, calltype)
+        case = analyze_method!(match, sig.atypes, state, calltype, flag)
         case === nothing && return
         push!(cases, Pair{Any,Any}(match.spec_types, case))
     end
@@ -1241,7 +1231,7 @@ end
 
 function maybe_handle_const_call!(ir::IRCode, idx::Int, stmt::Expr,
         info::ConstCallInfo, sig::Signature, @nospecialize(calltype),
-        state::InliningState,
+        state::InliningState, flag::UInt8,
         isinvoke::Bool, todo::Vector{Pair{Int, Any}})
     # when multiple matches are found, bail out and later inliner will union-split this signature
     # TODO effectively use multiple constant analysis results here
@@ -1253,7 +1243,7 @@ function maybe_handle_const_call!(ir::IRCode, idx::Int, stmt::Expr,
     validate_sparams(item.mi.sparam_vals) || return true
     mthd_sig = item.mi.def.sig
     mistypes = item.mi.specTypes
-    state.mi_cache !== nothing && (item = resolve_todo(item, state))
+    state.mi_cache !== nothing && (item = resolve_todo(item, state, flag))
     if sig.atype <: mthd_sig
         handle_single_case!(ir, stmt, idx, item, isinvoke, todo)
         return true
@@ -1291,6 +1281,8 @@ function assemble_inline_todo!(ir::IRCode, state::InliningState)
             info = info.info
         end
 
+        flag = ir.stmts[idx][:flag]
+
         # Inference determined this couldn't be analyzed. Don't question it.
         if info === false
             continue
@@ -1300,7 +1292,8 @@ function assemble_inline_todo!(ir::IRCode, state::InliningState)
         # it'll have performed a specialized analysis for just this case. Use its
         # result.
         if isa(info, ConstCallInfo)
-            if maybe_handle_const_call!(ir, idx, stmt, info, sig, calltype, state, sig.f === Core.invoke, todo)
+            if !is_stmt_noinline(flag) && maybe_handle_const_call!(
+                ir, idx, stmt, info, sig, calltype, state, flag, sig.f === Core.invoke, todo)
                 continue
             else
                 info = info.call
@@ -1308,7 +1301,7 @@ function assemble_inline_todo!(ir::IRCode, state::InliningState)
         end
 
         if isa(info, OpaqueClosureCallInfo)
-            result = analyze_method!(info.match, sig.atypes, state, calltype)
+            result = analyze_method!(info.match, sig.atypes, state, calltype, flag)
             handle_single_case!(ir, stmt, idx, result, false, todo)
             continue
         end
@@ -1316,7 +1309,7 @@ function assemble_inline_todo!(ir::IRCode, state::InliningState)
         # Handle invoke
         if sig.f === Core.invoke
             if isa(info, InvokeCallInfo)
-                inline_invoke!(ir, idx, sig, info, state, todo)
+                inline_invoke!(ir, idx, sig, info, state, todo, flag)
             end
             continue
         end
@@ -1330,7 +1323,7 @@ function assemble_inline_todo!(ir::IRCode, state::InliningState)
             continue
         end
 
-        analyze_single_call!(ir, todo, idx, stmt, sig, calltype, infos, state)
+        analyze_single_call!(ir, todo, idx, stmt, sig, calltype, infos, state, flag)
     end
     todo
 end
diff --git a/base/compiler/typeinfer.jl b/base/compiler/typeinfer.jl
index 4ad96ae2e72f0..7a6df9e6bc231 100644
--- a/base/compiler/typeinfer.jl
+++ b/base/compiler/typeinfer.jl
@@ -343,7 +343,7 @@ function maybe_compress_codeinfo(interp::AbstractInterpreter, linfo::MethodInsta
             nslots = length(ci.slotflags)
             resize!(ci.slottypes, nslots)
             resize!(ci.slotnames, nslots)
-            return ccall(:jl_compress_ir, Any, (Any, Any), def, ci)
+            return ccall(:jl_compress_ir, Vector{UInt8}, (Any, Any), def, ci)
         else
             return ci
         end
diff --git a/base/compiler/types.jl b/base/compiler/types.jl
index 773047d2b00e5..a579fa13f4989 100644
--- a/base/compiler/types.jl
+++ b/base/compiler/types.jl
@@ -10,10 +10,10 @@ swapped in as long as they follow the AbstractInterpreter API.
 
 All AbstractInterpreters are expected to provide at least the following methods:
 
-- InferenceParams(interp) - return an `InferenceParams` instance
-- OptimizationParams(interp) - return an `OptimizationParams` instance
-- get_world_counter(interp) - return the world age for this interpreter
-- get_inference_cache(interp) - return the runtime inference cache
+- `InferenceParams(interp)` - return an `InferenceParams` instance
+- `OptimizationParams(interp)` - return an `OptimizationParams` instance
+- `get_world_counter(interp)` - return the world age for this interpreter
+- `get_inference_cache(interp)` - return the runtime inference cache
 """
 abstract type AbstractInterpreter; end
 
diff --git a/base/compiler/utilities.jl b/base/compiler/utilities.jl
index 3b84395c676d2..58b2eeeeb9aef 100644
--- a/base/compiler/utilities.jl
+++ b/base/compiler/utilities.jl
@@ -59,7 +59,8 @@ end
 
 # Meta expression head, these generally can't be deleted even when they are
 # in a dead branch but can be ignored when analyzing uses/liveness.
-is_meta_expr_head(head::Symbol) = (head === :inbounds || head === :boundscheck || head === :meta || head === :loopinfo)
+is_meta_expr_head(head::Symbol) = (head === :inbounds || head === :boundscheck || head === :meta ||
+    head === :loopinfo || head === :inline || head === :noinline)
 
 sym_isless(a::Symbol, b::Symbol) = ccall(:strcmp, Int32, (Ptr{UInt8}, Ptr{UInt8}), a, b) < 0
 
@@ -187,7 +188,7 @@ function specialize_method(method::Method, @nospecialize(atypes), sparams::Simpl
     if preexisting
         # check cached specializations
         # for an existing result stored there
-        return ccall(:jl_specializations_lookup, Any, (Any, Any), method, atypes)
+        return ccall(:jl_specializations_lookup, Any, (Any, Any), method, atypes)::Union{Nothing,MethodInstance}
     end
     return ccall(:jl_specializations_get_linfo, Ref{MethodInstance}, (Any, Any, Any), method, atypes, sparams)
 end
diff --git a/base/compiler/validation.jl b/base/compiler/validation.jl
index f6b89f8f5cd04..0c49ccd2bb269 100644
--- a/base/compiler/validation.jl
+++ b/base/compiler/validation.jl
@@ -16,6 +16,8 @@ const VALID_EXPR_HEADS = IdDict{Symbol,UnitRange}(
     :leave => 1:1,
     :pop_exception => 1:1,
     :inbounds => 1:1,
+    :inline => 1:1,
+    :noinline => 1:1,
     :boundscheck => 0:0,
     :copyast => 1:1,
     :meta => 0:typemax(Int),
@@ -141,7 +143,7 @@ function validate_code!(errors::Vector{>:InvalidCodeError}, c::CodeInfo, is_top_
                 head === :const || head === :enter || head === :leave || head === :pop_exception ||
                 head === :method || head === :global || head === :static_parameter ||
                 head === :new || head === :splatnew || head === :thunk || head === :loopinfo ||
-                head === :throw_undef_if_not || head === :code_coverage_effect
+                head === :throw_undef_if_not || head === :code_coverage_effect || head === :inline || head === :noinline
                 validate_val!(x)
             else
                 # TODO: nothing is actually in statement position anymore
diff --git a/base/expr.jl b/base/expr.jl
index 9df363714679e..483e75067e478 100644
--- a/base/expr.jl
+++ b/base/expr.jl
@@ -209,11 +209,52 @@ end
 
 !!! compat "Julia 1.8"
     The usage within a function body requires at least Julia 1.8.
+
+---
+    @inline block
+
+Give a hint to the compiler that calls within `block` are worth inlining.
+
+```julia
+# The compiler will try to inline `f`
+@inline f(...)
+
+# The compiler will try to inline `f`, `g` and `+`
+@inline f(...) + g(...)
+```
+
+!!! note
+    A callsite annotation always has the precedence over the annotation applied to the
+    definition of the called function:
+    ```julia
+    @noinline function explicit_noinline(args...)
+        # body
+    end
+
+    let
+        @inline explicit_noinline(args...) # will be inlined
+    end
+    ```
+
+!!! note
+    When there are nested callsite annotations, the innermost annotation has the precedence:
+    ```julia
+    @noinline let a0, b0 = ...
+        a = @inline f(a0)  # the compiler will try to inline this call
+        b = f(b0)          # the compiler will NOT try to inline this call
+        return a, b
+    end
+    ```
+
+!!! compat "Julia 1.8"
+    The callsite annotation requires at least Julia 1.8.
 """
-macro inline(ex)
-    esc(isa(ex, Expr) ? pushmeta!(ex, :inline) : ex)
+macro inline(x)
+    return annotate_meta_def_or_block(x, :inline)
+end
+macro inline()
+    return Expr(:meta, :inline)
 end
-macro inline() Expr(:meta, :inline) end
 
 """
     @noinline
@@ -245,13 +286,55 @@ end
 !!! compat "Julia 1.8"
     The usage within a function body requires at least Julia 1.8.
 
+---
+    @noinline block
+
+Give a hint to the compiler that it should not inline the calls within `block`.
+
+```julia
+# The compiler will try to not inline `f`
+@noinline f(...)
+
+# The compiler will try to not inline `f`, `g` and `+`
+@noinline f(...) + g(...)
+```
+
+!!! note
+    A callsite annotation always has the precedence over the annotation applied to the
+    definition of the called function:
+    ```julia
+    @inline function explicit_inline(args...)
+        # body
+    end
+
+    let
+        @noinline explicit_inline(args...) # will not be inlined
+    end
+    ```
+
+!!! note
+    When there are nested callsite annotations, the innermost annotation has the precedence:
+    ```julia
+    @inline let a0, b0 = ...
+        a = @noinline f(a0)  # the compiler will NOT try to inline this call
+        b = f(b0)            # the compiler will try to inline this call
+        return a, b
+    end
+    ```
+
+!!! compat "Julia 1.8"
+    The callsite annotation requires at least Julia 1.8.
+
+---
 !!! note
     If the function is trivial (for example returning a constant) it might get inlined anyway.
 """
-macro noinline(ex)
-    esc(isa(ex, Expr) ? pushmeta!(ex, :noinline) : ex)
+macro noinline(x)
+    return annotate_meta_def_or_block(x, :noinline)
+end
+macro noinline()
+    return Expr(:meta, :noinline)
 end
-macro noinline() Expr(:meta, :noinline) end
 
 """
     @pure ex
@@ -303,6 +386,15 @@ end
 
 ## some macro utilities ##
 
+unwrap_macrocalls(@nospecialize(x)) = x
+function unwrap_macrocalls(ex::Expr)
+    inner = ex
+    while inner.head === :macrocall
+        inner = inner.args[end]::Expr
+    end
+    return inner
+end
+
 function pushmeta!(ex::Expr, sym::Symbol, args::Any...)
     if isempty(args)
         tag = sym
@@ -310,10 +402,7 @@ function pushmeta!(ex::Expr, sym::Symbol, args::Any...)
         tag = Expr(sym, args...)::Expr
     end
 
-    inner = ex
-    while inner.head === :macrocall
-        inner = inner.args[end]::Expr
-    end
+    inner = unwrap_macrocalls(ex)
 
     idx, exargs = findmeta(inner)
     if idx != 0
@@ -363,8 +452,23 @@ function findmetaarg(metaargs, sym)
     return 0
 end
 
-function is_short_function_def(ex)
-    ex.head === :(=) || return false
+function annotate_meta_def_or_block(@nospecialize(ex), meta::Symbol)
+    inner = unwrap_macrocalls(ex)
+    if is_function_def(inner)
+        # annotation on a definition
+        return esc(pushmeta!(ex, meta))
+    else
+        # annotation on a block
+        return Expr(:block,
+                    Expr(meta, true),
+                    Expr(:local, Expr(:(=), :val, esc(ex))),
+                    Expr(meta, false),
+                    :val)
+    end
+end
+
+function is_short_function_def(@nospecialize(ex))
+    isexpr(ex, :(=)) || return false
     while length(ex.args) >= 1 && isa(ex.args[1], Expr)
         (ex.args[1].head === :call) && return true
         (ex.args[1].head === :where || ex.args[1].head === :(::)) || return false
@@ -372,9 +476,11 @@ function is_short_function_def(ex)
     end
     return false
 end
+is_function_def(@nospecialize(ex)) =
+    return isexpr(ex, :function) || is_short_function_def(ex) || isexpr(ex, :->)
 
 function findmeta(ex::Expr)
-    if ex.head === :function || is_short_function_def(ex) || ex.head === :->
+    if is_function_def(ex)
         body = ex.args[2]::Expr
         body.head === :block || error(body, " is not a block expression")
         return findmeta_block(ex.args)
diff --git a/base/meta.jl b/base/meta.jl
index aaf29b551cd0d..4f29b83cb92f5 100644
--- a/base/meta.jl
+++ b/base/meta.jl
@@ -423,6 +423,7 @@ end
 
 _instantiate_type_in_env(x, spsig, spvals) = ccall(:jl_instantiate_type_in_env, Any, (Any, Any, Ptr{Any}), x, spsig, spvals)
 
-is_meta_expr_head(head::Symbol) = (head === :inbounds || head === :boundscheck || head === :meta || head === :loopinfo)
+is_meta_expr_head(head::Symbol) = (head === :inbounds || head === :boundscheck || head === :meta
+                                   || head === :loopinfo || head === :inline || head === :noinline)
 
 end # module
diff --git a/src/ast.scm b/src/ast.scm
index 005afb4647f5f..16667c2f01c5b 100644
--- a/src/ast.scm
+++ b/src/ast.scm
@@ -289,7 +289,7 @@
 ;; predicates and accessors
 
 (define (quoted? e)
-  (memq (car e) '(quote top core globalref outerref line break inert meta inbounds loopinfo)))
+  (memq (car e) '(quote top core globalref outerref line break inert meta inbounds inline noinline loopinfo)))
 (define (quotify e) `',e)
 (define (unquote e)
   (if (and (pair? e) (memq (car e) '(quote inert)))
diff --git a/src/codegen.cpp b/src/codegen.cpp
index dc03d453d4578..2a9d24c380f4e 100644
--- a/src/codegen.cpp
+++ b/src/codegen.cpp
@@ -4396,7 +4396,7 @@ static void emit_stmtpos(jl_codectx_t &ctx, jl_value_t *expr, int ssaval_result)
     jl_value_t **args = (jl_value_t**)jl_array_data(ex->args);
     jl_sym_t *head = ex->head;
     if (head == meta_sym || head == inbounds_sym || head == coverageeffect_sym
-            || head == aliasscope_sym || head == popaliasscope_sym) {
+            || head == aliasscope_sym || head == popaliasscope_sym || head == inline_sym || head == noinline_sym) {
         // some expression types are metadata and can be ignored
         // in statement position
         return;
@@ -4831,7 +4831,7 @@ static jl_cgval_t emit_expr(jl_codectx_t &ctx, jl_value_t *expr, ssize_t ssaval)
     }
     else if (head == leave_sym || head == coverageeffect_sym
             || head == pop_exception_sym || head == enter_sym || head == inbounds_sym
-            || head == aliasscope_sym || head == popaliasscope_sym) {
+            || head == aliasscope_sym || head == popaliasscope_sym || head == inline_sym || head == noinline_sym) {
         jl_errorf("Expr(:%s) in value position", jl_symbol_name(head));
     }
     else if (head == boundscheck_sym) {
diff --git a/src/interpreter.c b/src/interpreter.c
index 7858bd6ddc4ea..2be907e82513c 100644
--- a/src/interpreter.c
+++ b/src/interpreter.c
@@ -311,7 +311,7 @@ static jl_value_t *eval_value(jl_value_t *e, interpreter_state *s)
         return jl_true;
     }
     else if (head == meta_sym || head == coverageeffect_sym || head == inbounds_sym || head == loopinfo_sym ||
-             head == aliasscope_sym || head == popaliasscope_sym) {
+             head == aliasscope_sym || head == popaliasscope_sym || head == inline_sym || head == noinline_sym) {
         return jl_nothing;
     }
     else if (head == gc_preserve_begin_sym || head == gc_preserve_end_sym) {
diff --git a/src/julia-syntax.scm b/src/julia-syntax.scm
index d80c6a5052c85..35a4558d9d56a 100644
--- a/src/julia-syntax.scm
+++ b/src/julia-syntax.scm
@@ -3495,7 +3495,7 @@ f(x) = yt(x)
          thunk with-static-parameters toplevel-only
          global globalref outerref const-if-global thismodule
          const atomic null true false ssavalue isdefined toplevel module lambda
-         error gc_preserve_begin gc_preserve_end import using export)))
+         error gc_preserve_begin gc_preserve_end import using export inline noinline)))
 
 (define (local-in? s lam)
   (or (assq s (car  (lam:vinfo lam)))
@@ -4589,7 +4589,7 @@ f(x) = yt(x)
                (cons (car e) args)))
 
             ;; metadata expressions
-            ((line meta inbounds loopinfo gc_preserve_end aliasscope popaliasscope)
+            ((line meta inbounds loopinfo gc_preserve_end aliasscope popaliasscope inline noinline)
              (let ((have-ret? (and (pair? code) (pair? (car code)) (eq? (caar code) 'return))))
                (cond ((eq? (car e) 'line)
                       (set! current-loc e)
@@ -4734,7 +4734,7 @@ f(x) = yt(x)
           (begin (set! linetable (cons (make-lineinfo name file line) linetable))
                  (set! current-loc 1)))
       (if (or reachable
-              (and (pair? e) (memq (car e) '(meta inbounds gc_preserve_begin gc_preserve_end aliasscope popaliasscope))))
+              (and (pair? e) (memq (car e) '(meta inbounds gc_preserve_begin gc_preserve_end aliasscope popaliasscope inline noinline))))
           (begin (set! code (cons e code))
                  (set! i (+ i 1))
                  (set! locs (cons current-loc locs)))))
diff --git a/src/macroexpand.scm b/src/macroexpand.scm
index 5e55c7bbb29c1..f17f4d3510dc6 100644
--- a/src/macroexpand.scm
+++ b/src/macroexpand.scm
@@ -352,7 +352,7 @@
                                    ,(resolve-expansion-vars-with-new-env (caddr arg) env m parent-scope inarg))))
                              (else
                               `(global ,(resolve-expansion-vars-with-new-env arg env m parent-scope inarg))))))
-           ((using import export meta line inbounds boundscheck loopinfo) (map unescape e))
+           ((using import export meta line inbounds boundscheck loopinfo inline noinline) (map unescape e))
            ((macrocall) e) ; invalid syntax anyways, so just act like it's quoted.
            ((symboliclabel) e)
            ((symbolicgoto) e)
diff --git a/src/method.c b/src/method.c
index 48b074e800904..852a7ff88208a 100644
--- a/src/method.c
+++ b/src/method.c
@@ -84,7 +84,8 @@ static jl_value_t *resolve_globals(jl_value_t *expr, jl_module_t *module, jl_sve
             e->head == quote_sym || e->head == inert_sym ||
             e->head == meta_sym || e->head == inbounds_sym ||
             e->head == boundscheck_sym || e->head == loopinfo_sym ||
-            e->head == aliasscope_sym || e->head == popaliasscope_sym) {
+            e->head == aliasscope_sym || e->head == popaliasscope_sym ||
+            e->head == inline_sym || e->head == noinline_sym) {
             // ignore these
         }
         else {
diff --git a/test/compiler/inline.jl b/test/compiler/inline.jl
index 00797304ce5c0..1282fe5f2dd07 100644
--- a/test/compiler/inline.jl
+++ b/test/compiler/inline.jl
@@ -498,6 +498,96 @@ end
     end
 end
 
+@testset "callsite @inline/@noinline annotations" begin
+    m = Module()
+    @eval m begin
+        # this global variable prevents inference to fold everything as constant, and/or the optimizer to inline the call accessing to this
+        g = 0
+
+        @noinline noinlined_explicit(x) = x
+        force_inline_explicit(x)        = @inline noinlined_explicit(x)
+        force_inline_block_explicit(x)  = @inline noinlined_explicit(x) + noinlined_explicit(x)
+        noinlined_implicit(x)          = g
+        force_inline_implicit(x)       = @inline noinlined_implicit(x)
+        force_inline_block_implicit(x) = @inline noinlined_implicit(x) + noinlined_implicit(x)
+
+        @inline inlined_explicit(x)      = x
+        force_noinline_explicit(x)       = @noinline inlined_explicit(x)
+        force_noinline_block_explicit(x) = @noinline inlined_explicit(x) + inlined_explicit(x)
+        inlined_implicit(x)              = x
+        force_noinline_implicit(x)       = @noinline inlined_implicit(x)
+        force_noinline_block_implicit(x) = @noinline inlined_implicit(x) + inlined_implicit(x)
+
+        # test callsite annotations for constant-prop'ed calls
+
+        @noinline Base.@aggressive_constprop noinlined_constprop_explicit(a) = a+g
+        force_inline_constprop_explicit()                                    = @inline noinlined_constprop_explicit(0)
+        Base.@aggressive_constprop noinlined_constprop_implicit(a) = a+g
+        force_inline_constprop_implicit()                          = @inline noinlined_constprop_implicit(0)
+
+        @inline Base.@aggressive_constprop inlined_constprop_explicit(a) = a+g
+        force_noinline_constprop_explicit()                              = @noinline inlined_constprop_explicit(0)
+        @inline Base.@aggressive_constprop inlined_constprop_implicit(a) = a+g
+        force_noinline_constprop_implicit()                              = @noinline inlined_constprop_implicit(0)
+
+        @noinline notinlined(a) = a
+        function nested(a0, b0)
+            @noinline begin
+                a = @inline notinlined(a0) # this call should be inlined
+                b = notinlined(b0) # this call should NOT be inlined
+                return a, b
+            end
+        end
+    end
+
+    let ci = code_typed1(m.force_inline_explicit, (Int,))
+        @test all(x->!isinvoke(x, :noinlined_explicit), ci.code)
+    end
+    let ci = code_typed1(m.force_inline_block_explicit, (Int,))
+        @test all(ci.code) do x
+            !isinvoke(x, :noinlined_explicit) &&
+            !isinvoke(x, :(+))
+        end
+    end
+    let ci = code_typed1(m.force_inline_implicit, (Int,))
+        @test all(x->!isinvoke(x, :noinlined_implicit), ci.code)
+    end
+    let ci = code_typed1(m.force_inline_block_implicit, (Int,))
+        @test all(x->!isinvoke(x, :noinlined_explicit), ci.code)
+    end
+
+    let ci = code_typed1(m.force_noinline_explicit, (Int,))
+        @test any(x->isinvoke(x, :inlined_explicit), ci.code)
+    end
+    let ci = code_typed1(m.force_noinline_block_explicit, (Int,))
+        @test count(x->isinvoke(x, :inlined_explicit), ci.code) == 2
+    end
+    let ci = code_typed1(m.force_noinline_implicit, (Int,))
+        @test any(x->isinvoke(x, :inlined_implicit), ci.code)
+    end
+    let ci = code_typed1(m.force_noinline_block_implicit, (Int,))
+        @test count(x->isinvoke(x, :inlined_implicit), ci.code) == 2
+    end
+
+    let ci = code_typed1(m.force_inline_constprop_explicit)
+        @test all(x->!isinvoke(x, :noinlined_constprop_explicit), ci.code)
+    end
+    let ci = code_typed1(m.force_inline_constprop_implicit)
+        @test all(x->!isinvoke(x, :noinlined_constprop_implicit), ci.code)
+    end
+
+    let ci = code_typed1(m.force_noinline_constprop_explicit)
+        @test any(x->isinvoke(x, :inlined_constprop_explicit), ci.code)
+    end
+    let ci = code_typed1(m.force_noinline_constprop_implicit)
+        @test any(x->isinvoke(x, :inlined_constprop_implicit), ci.code)
+    end
+
+    let ci = code_typed1(m.nested, (Int,Int))
+        @test count(x->isinvoke(x, :notinlined), ci.code) == 1
+    end
+end
+
 # Issue #41299 - inlining deletes error check in :>
 g41299(f::Tf, args::Vararg{Any,N}) where {Tf,N} = f(args...)
 @test_throws TypeError g41299(>:, 1, 2)