diff --git a/tools/oldest_constraints.txt b/tools/oldest_constraints.txt
index de2b83ad8b1..7992cf60b0b 100644
--- a/tools/oldest_constraints.txt
+++ b/tools/oldest_constraints.txt
@@ -20,7 +20,7 @@ six==1.9.0
 # setuptools 0.9.8 is the actual version packaged, but some other dependencies
 # in this file require setuptools>=1.0 and there are no relevant changes for us
 # between these versions.
-setuptools==1.0.0
+setuptools==49.3.1
 urllib3==1.10.2
 zope.component==4.1.0
 zope.event==4.0.3