diff --git a/Formula/p/pythran.rb b/Formula/p/pythran.rb
index 9c2bd52a8dae..23474e65a3f9 100644
--- a/Formula/p/pythran.rb
+++ b/Formula/p/pythran.rb
@@ -3,8 +3,8 @@ class Pythran < Formula
 
   desc "Ahead of Time compiler for numeric kernels"
   homepage "https://pythran.readthedocs.io/"
-  url "https://files.pythonhosted.org/packages/73/32/f892675c5009cd4c1895ded3d6153476bf00adb5ad1634d03635620881f5/pythran-0.16.1.tar.gz"
-  sha256 "861748c0f9c7d422b32724b114b3817d818ed4eab86c09781aa0a3f7ceabb7f9"
+  url "https://files.pythonhosted.org/packages/34/2d/4ac363a2eecd68c372b058d1b95a5f262c70776e107619cdcb5a4b68e1a3/pythran-0.17.0.tar.gz"
+  sha256 "3b77d6d970a6cf5b448facc7d4f6229c3e73909ac27ea2480c843afdadbad0fb"
   license "BSD-3-Clause"
   head "https://github.com/serge-sans-paille/pythran.git", branch: "master"
 
@@ -24,13 +24,13 @@ class Pythran < Formula
   depends_on "python@3.12"
 
   resource "beniget" do
-    url "https://files.pythonhosted.org/packages/14/e7/50cbac38f77eca8efd39516be6651fdb9f3c4c0fab8cf2cf05f612578737/beniget-0.4.1.tar.gz"
-    sha256 "75554b3b8ad0553ce2f607627dad3d95c60c441189875b98e097528f8e23ac0c"
+    url "https://files.pythonhosted.org/packages/2e/27/5bb01af8f2860d431b98d0721b96ff2cea979106cae3f2d093ec74f6400c/beniget-0.4.2.post1.tar.gz"
+    sha256 "a0258537e65e7e14ec33a86802f865a667f949bb6c73646d55e42f7c45a052ae"
   end
 
   resource "gast" do
-    url "https://files.pythonhosted.org/packages/e4/41/f26f62ebef1a80148e20951a6e9ef4d0ebbe2090124bc143da26e12a934c/gast-0.5.4.tar.gz"
-    sha256 "9c270fe5f4b130969b54174de7db4e764b09b4f7f67ccfc32480e29f78348d97"
+    url "https://files.pythonhosted.org/packages/3c/14/c566f5ca00c115db7725263408ff952b8ae6d6a4e792ef9c84e77d9af7a1/gast-0.6.0.tar.gz"
+    sha256 "88fc5300d32c7ac6ca7b515310862f71e6fdf2c029bbec7c66c0f5dd47b6b1fb"
   end
 
   resource "ply" do
@@ -39,8 +39,8 @@ class Pythran < Formula
   end
 
   resource "setuptools" do
-    url "https://files.pythonhosted.org/packages/aa/60/5db2249526c9b453c5bb8b9f6965fcab0ddb7f40ad734420b3b421f7da44/setuptools-70.0.0.tar.gz"
-    sha256 "f211a66637b8fa059bb28183da127d4e86396c991a942b028c6650d4319c3fd0"
+    url "https://files.pythonhosted.org/packages/ed/22/a438e0caa4576f8c383fa4d35f1cc01655a46c75be358960d815bfbb12bd/setuptools-75.3.0.tar.gz"
+    sha256 "fba5dd4d766e97be1b1681d98712680ae8f2f26d7881245f2ce9e40714f1a686"
   end
 
   def install