diff --git a/jmxfetch.py b/jmxfetch.py
index 0fe4bdd06a..94b228eabd 100644
--- a/jmxfetch.py
+++ b/jmxfetch.py
@@ -94,8 +94,10 @@ def register_signal_handlers(self):
 
     def configure(self, check_list=None):
         """
-        Instantiate JMXFetch parameters.
+        Instantiate JMXFetch parameters, clean potential previous run leftovers.
         """
+        _clean_status_file()
+
         self.jmx_checks, self.invalid_checks, self.java_bin_path, self.java_options, self.tools_jar_path = \
             self.get_configuration(check_list)
 
@@ -384,6 +386,16 @@ def _get_path_to_jmxfetch(self):
                                 "jmxfetch", JMX_FETCH_JAR_NAME))
 
 
+def _clean_status_file():
+    """
+    Removes Python JMX status file
+    """
+    try:
+        os.remove(os.path.join(get_jmx_status_path(), PYTHON_JMX_STATUS_FILE))
+    except OSError:
+        pass
+
+
 def _get_jmx_appnames():
     """
     Retrieves the running JMX checks based on the {tmp}/jmx_status.yaml file