diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 2094d79c4ee..e8e05c9cafd 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -388,6 +388,56 @@ jobs:
       run:
         python3 `which scons` test show_long_tests=yes verbose_tests=yes --debug=time
 
+  windows-2022:
+    name: ${{ matrix.os }}, MSVC ${{ matrix.vs-toolset }}, Python ${{ matrix.python-version }}
+    runs-on: ${{ matrix.os }}
+    timeout-minutes: 60
+    defaults:
+      run:
+        shell: bash -l {0}
+    strategy:
+      matrix:
+        os: ["windows-2022"]
+        vs-toolset: ["14.0", "14.1", "14.2", "14.3"]
+        python-version: [ "3.6", "3.10" ]
+      fail-fast: false
+    steps:
+      - uses: actions/checkout@v2
+        name: Checkout the repository
+        with:
+          submodules: recursive
+      - name: Cache conda
+        uses: actions/cache@v2
+        env:
+          # Increase this value to reset cache if etc/example-environment.yml has not changed
+          CACHE_NUMBER: 0
+        with:
+          path: ~/conda_pkgs_dir
+          key:
+            ${{ runner.os }}-conda-${{ env.CACHE_NUMBER }}
+      - uses: conda-incubator/setup-miniconda@v2
+        with:
+          auto-update-conda: true
+          python-version: ${{ matrix.python-version }}
+          activate-environment: test
+          miniforge-version: latest
+          channels: conda-forge,defaults
+          channel-priority: strict
+          use-only-tar-bz2: true # IMPORTANT: This needs to be set for caching to work properly!
+        name: Set up conda
+      - name: Install conda dependencies
+        # See https://github.com/conda-forge/boost-cpp-feedstock/issues/41 for why we
+        # use boost-cpp rather than boost from conda-forge
+        run: |
+          conda install -q scons numpy cython ruamel_yaml boost-cpp fmt eigen yaml-cpp h5py pandas pytest
+        shell: pwsh
+      - name: Build Cantera
+        run: scons build system_fmt=y system_eigen=y system_yamlcpp=y VERBOSE=True debug=n
+          msvc_version=${{ matrix.vs-toolset }} f90_interface=n --debug=time -j2
+        shell: pwsh
+      - name: Test Cantera
+        run: scons test show_long_tests=yes verbose_tests=yes --debug=time
+
   windows:
     name: ${{ matrix.os }}, MSVC ${{ matrix.vs-toolset }}, Python ${{ matrix.python-version }}
     runs-on: ${{ matrix.os }}
@@ -400,21 +450,6 @@ jobs:
         os: ['windows-2019']
         vs-toolset: ['14.0', '14.2']
         python-version: [ '3.6', '3.9', '3.10' ]
-        # Must use windows-2016 image because it installs VS2017 (MSVC 14.1)
-        # Scons cannot find MSVC 14.1 when VS2019 is installed
-        include:
-          - os: 'windows-2016'
-            vs-toolset: '14.1'
-            python-version: '3.6'
-          - os: 'windows-2016'
-            vs-toolset: '14.1'
-            python-version: '3.7'
-          - os: 'windows-2016'
-            vs-toolset: '14.1'
-            python-version: '3.8'
-          - os: 'windows-2016'
-            vs-toolset: '14.1'
-            python-version: '3.9'
       fail-fast: false
     steps:
       - uses: actions/checkout@v2