diff --git a/include/highfive/bits/H5Slice_traits.hpp b/include/highfive/bits/H5Slice_traits.hpp
index 6812a0914..a7202de07 100644
--- a/include/highfive/bits/H5Slice_traits.hpp
+++ b/include/highfive/bits/H5Slice_traits.hpp
@@ -163,16 +163,27 @@ class HyperSlab {
 
     DataSpace apply(const DataSpace& space_) const {
         auto space = space_.clone();
-        for (const auto& sel: selects) {
-            if (sel.op == Op::None) {
+        auto n_selects = selects.size();
+        for (size_t i = 0; i < n_selects; ++i) {
+            auto begin = selects.data() + i;
+            auto end = selects.data() + n_selects;
+
+            auto n_ors = detect_ors(begin, end);
+
+            if (n_ors > 1) {
+                auto right_space = reduce_ors(space_, begin, begin + n_ors);
+                // Since HDF5 doesn't allow `combine_selections` with a None
+                // selection, we need to avoid the issue:
+                if (H5Sget_select_type(space.getId()) == H5S_SEL_NONE) {
+                    space = right_space;
+                } else {
+                    space = combine_selections(space, Op::Or, right_space);
+                }
+                i += n_ors - 1;
+            } else if (selects[i].op == Op::None) {
                 detail::h5s_select_none(space.getId());
             } else {
-                detail::h5s_select_hyperslab(space.getId(),
-                                             convert(sel.op),
-                                             sel.offset.empty() ? nullptr : sel.offset.data(),
-                                             sel.stride.empty() ? nullptr : sel.stride.data(),
-                                             sel.count.empty() ? nullptr : sel.count.data(),
-                                             sel.block.empty() ? nullptr : sel.block.data());
+                select_hyperslab(space, selects[i]);
             }
         }
         return space;
@@ -229,6 +240,63 @@ class HyperSlab {
     };
 
     std::vector<Select_> selects;
+
+  protected:
+    size_t detect_ors(Select_ const* begin, Select_ const* end) const {
+        size_t streak = 0;
+        for (Select_ const* it = begin; it != end; ++it) {
+            if (it->op == Op::Or) {
+                ++streak;
+            } else {
+                break;
+            }
+        }
+
+        return streak;
+    }
+
+    DataSpace select_none(const DataSpace& outer_space) const {
+        auto space = outer_space.clone();
+        detail::h5s_select_none(space.getId());
+        return space;
+    }
+
+    void select_hyperslab(DataSpace& space, const Select_& sel) const {
+        detail::h5s_select_hyperslab(space.getId(),
+                                     convert(sel.op),
+                                     sel.offset.empty() ? nullptr : sel.offset.data(),
+                                     sel.stride.empty() ? nullptr : sel.stride.data(),
+                                     sel.count.empty() ? nullptr : sel.count.data(),
+                                     sel.block.empty() ? nullptr : sel.block.data());
+    }
+
+    DataSpace combine_selections(const DataSpace& left_space,
+                                 Op op,
+                                 const DataSpace& right_space) const {
+        return detail::make_data_space(
+            H5Scombine_select(left_space.getId(), convert(op), right_space.getId()));
+    }
+
+    DataSpace reduce_ors(const DataSpace& outer_space,
+                         Select_ const* begin,
+                         Select_ const* end) const {
+        if (begin == end) {
+            throw std::runtime_error("Broken logic.");
+        }
+
+        std::ptrdiff_t distance = end - begin;
+        if (distance == 1) {
+            auto space = select_none(outer_space);
+            select_hyperslab(space, *begin);
+            return space;
+        }
+
+        Select_ const* mid = begin + distance / 2;
+        auto right_space = reduce_ors(outer_space, begin, mid);
+        auto left_space = reduce_ors(outer_space, mid, end);
+
+        return combine_selections(left_space, Op::Or, right_space);
+    }
 };
 
 ///
diff --git a/tests/unit/test_high_five_selection.cpp b/tests/unit/test_high_five_selection.cpp
index e3b91e4cc..1979f3ca0 100644
--- a/tests/unit/test_high_five_selection.cpp
+++ b/tests/unit/test_high_five_selection.cpp
@@ -25,6 +25,7 @@
 
 #include <highfive/highfive.hpp>
 #include "tests_high_five.hpp"
+#include "data_generator.hpp"
 
 using namespace HighFive;
 using Catch::Matchers::Equals;
@@ -534,3 +535,60 @@ void irregularHyperSlabSelectionWriteTest() {
 TEMPLATE_LIST_TEST_CASE("irregularHyperSlabSelectionWrite", "[template]", std::tuple<int>) {
     irregularHyperSlabSelectionWriteTest<TestType>();
 }
+
+TEST_CASE("select_multiple_ors", "[hyperslab]") {
+    size_t n = 100, m = 20;
+    size_t nsel = 30;
+    auto x = testing::DataGenerator<std::vector<std::vector<int>>>::create({n, m});
+
+    auto file = File("select_multiple_ors.h5", File::Truncate);
+    auto dset = file.createDataSet("x", x);
+
+    std::vector<std::array<size_t, 2>> indices;
+    auto hyperslab = HyperSlab();
+    for (size_t i = 0; i < nsel; ++i) {
+        std::vector<size_t> offsets{i, i % 10};
+        std::vector<size_t> counts{1, 3};
+        hyperslab |= RegularHyperSlab(offsets, counts);
+
+        for (size_t k = 0; k < counts[1]; ++k) {
+            indices.push_back({offsets[0], offsets[1] + k});
+        }
+    }
+
+    SECTION("Pure Or Chain") {
+        auto selected = dset.select(hyperslab).read<std::vector<int>>();
+        REQUIRE(selected.size() == indices.size());
+        for (size_t k = 0; k < selected.size(); ++k) {
+            size_t i = indices[k][0];
+            size_t j = indices[k][1];
+            REQUIRE(selected[k] == x[i][j]);
+        }
+    }
+
+    SECTION("Or Chain And Slab") {
+        std::cout << " ................... " << std::endl;
+        std::vector<hsize_t> offsets{5, 2};
+        std::vector<hsize_t> counts{85, 12};
+
+        std::vector<std::array<size_t, 2>> selected_indices;
+        for (const auto ij: indices) {
+            std::array<size_t, 2> ij_max = {offsets[0] + counts[0], offsets[1] + counts[1]};
+
+            if (offsets[0] <= ij[0] && ij[0] < ij_max[0] && offsets[1] <= ij[1] &&
+                ij[1] < ij_max[1]) {
+                selected_indices.push_back(ij);
+            }
+        }
+
+        hyperslab &= RegularHyperSlab(offsets, counts);
+
+        auto selected = dset.select(hyperslab).read<std::vector<int>>();
+        REQUIRE(selected.size() == selected_indices.size());
+        for (size_t k = 0; k < selected.size(); ++k) {
+            size_t i = selected_indices[k][0];
+            size_t j = selected_indices[k][1];
+            REQUIRE(selected[k] == x[i][j]);
+        }
+    }
+}