diff --git a/cirq-google/cirq_google/engine/client/quantum_v1alpha1/gapic/quantum_engine_service_client.py b/cirq-google/cirq_google/engine/client/quantum_v1alpha1/gapic/quantum_engine_service_client.py
index 92ef60ebfffd..31b6fa724789 100644
--- a/cirq-google/cirq_google/engine/client/quantum_v1alpha1/gapic/quantum_engine_service_client.py
+++ b/cirq-google/cirq_google/engine/client/quantum_v1alpha1/gapic/quantum_engine_service_client.py
@@ -2106,6 +2106,9 @@ def quantum_run_stream(
                 default_timeout=self._method_configs['QuantumRunStream'].timeout,
                 client_info=self._client_info,
             )
+            # Don't prefetch first result from stream, since this will cause deadlocks.
+            # See https://github.com/googleapis/python-api-core/pull/30
+            self.transport.quantum_run_stream._prefetch_first_result_ = False
 
         return self._inner_api_calls['quantum_run_stream'](
             requests, retry=retry, timeout=timeout, metadata=metadata